Macrophages Transfected with Adenovirus to Express IL-4 Reduce Inflammation in Experimental Glomerulonephritis

Nephrotoxic nephritis (NTN) is characterized by acute macrophage-dependent inflammation and serves as a model of human glomerulonephritis. In this study we have transfected rat macrophages with recombinant adenovirus expressing IL-4 (Ad-IL4) and demonstrated that these transfected macrophages develo...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-04, Vol.166 (7), p.4728-4736
Hauptverfasser:	Kluth, David C, Ainslie, Clare V, Pearce, Wayne P, Finlay, Sian, Clarke, Daniel, Anegon, Ignacio, Rees, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - immunology adenovirus Animals Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bone Marrow Cells - virology Bone Marrow Transplantation Cell Count Cell Movement - genetics Cell Movement - immunology Disease Models, Animal Genetic Therapy - methods Glomerulonephritis - immunology Glomerulonephritis - pathology Glomerulonephritis - prevention & control Glomerulonephritis - virology Injections, Intra-Arterial Interferon-gamma - pharmacology Interleukin-4 - administration & dosage Interleukin-4 - biosynthesis Interleukin-4 - genetics Kidney Glomerulus - immunology Kidney Glomerulus - pathology Lipopolysaccharides - pharmacology Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Macrophages, Alveolar - transplantation Macrophages, Alveolar - virology Male Nitric Oxide - biosynthesis Proteinuria - immunology Proteinuria - pathology Proteinuria - therapy Rats Rats, Sprague-Dawley Renal Artery Transfection - methods Tumor Necrosis Factor-alpha - pharmacology
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