Paracetamol (acetaminophen) hypersensitivity
Acetaminophen (paracetamol) is an analgesic antipyretic drug with no antiinflammatory effects and is widely used worldwide. Earlier clinical studies reported IgE-mediated adverse reactions to acetaminophen, but in vivo and in vitro tests have been inconclusive. We propose to demonstrate an IgE-media...
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| Veröffentlicht in: | Annals of allergy, asthma, & immunology asthma, & immunology, 2000-12, Vol.85 (6), p.508-511 |
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| container_title | Annals of allergy, asthma, & immunology |
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| creator | Paramo, Berta Juliade Gancedo, Santiago Quirce Cuevas, Manuela Camo, Ignacio Perez Martin, Jose A. Cosmes, Eloy Losada |
| description | Acetaminophen (paracetamol) is an analgesic antipyretic drug with no antiinflammatory effects and is widely used worldwide. Earlier clinical studies reported IgE-mediated adverse reactions to acetaminophen, but in vivo and in vitro tests have been inconclusive.
We propose to demonstrate an IgE-mediated mechanism in four patients with adverse reactions to acetaminophen (paracetamol). Tolerance to aspirin and other nonsteroidal antiinflammatory drugs are present in all patients.
We studied four patients with anaphylactic reactions to acetaminophen who tolerated aspirin and other nonsteroidal antiinflammatory drugs. Skin tests, oral challenges and immunoassay for allergen-specific IgE antibodies with acetaminophen were performed in all patients.
All patients tolerated the aspirin oral challenge without adverse effects. In contrast, the oral challenge with acetaminophen produced adverse effects in all patients. Skin tests with acetaminophen were positive in two patients (3-mm wheal and flare) and IgE antibodies acetaminophen were detected in serum from two patients.
We describe four patients with adverse reactions to acetaminophen but with tolerance to aspirin and other nonsteroidal antiinflammatory drugs. Skin tests, oral challenges, and serum IgE results with acetaminophen suggest that an IgE-mediated mechanism is responsible for these reactions. |
| doi_str_mv | 10.1016/S1081-1206(10)62580-X |
| format | Article |
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We propose to demonstrate an IgE-mediated mechanism in four patients with adverse reactions to acetaminophen (paracetamol). Tolerance to aspirin and other nonsteroidal antiinflammatory drugs are present in all patients.
We studied four patients with anaphylactic reactions to acetaminophen who tolerated aspirin and other nonsteroidal antiinflammatory drugs. Skin tests, oral challenges and immunoassay for allergen-specific IgE antibodies with acetaminophen were performed in all patients.
All patients tolerated the aspirin oral challenge without adverse effects. In contrast, the oral challenge with acetaminophen produced adverse effects in all patients. Skin tests with acetaminophen were positive in two patients (3-mm wheal and flare) and IgE antibodies acetaminophen were detected in serum from two patients.
We describe four patients with adverse reactions to acetaminophen but with tolerance to aspirin and other nonsteroidal antiinflammatory drugs. Skin tests, oral challenges, and serum IgE results with acetaminophen suggest that an IgE-mediated mechanism is responsible for these reactions.</description><identifier>ISSN: 1081-1206</identifier><identifier>EISSN: 1534-4436</identifier><identifier>DOI: 10.1016/S1081-1206(10)62580-X</identifier><identifier>PMID: 11152174</identifier><identifier>CODEN: ANAEA3</identifier><language>eng</language><publisher>McLean, VA: Elsevier Inc</publisher><subject>Acetaminophen - adverse effects ; Adult ; Aged ; Analgesics, Non-Narcotic - adverse effects ; Biological and medical sciences ; Drug Hypersensitivity - etiology ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Hypersensitivity, Immediate - chemically induced ; Medical sciences ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Skin Tests</subject><ispartof>Annals of allergy, asthma, & immunology, 2000-12, Vol.85 (6), p.508-511</ispartof><rights>2000 American College of Allergy, Asthma & Immunology</rights><rights>2001 INIST-CNRS</rights><rights>Copyright American College of Allergy and Immunology Dec 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-e391d4aa85236f6d1941e60d900d3e77b9c79100fa3bbafdad41bf5d00f2ae6c3</citedby><cites>FETCH-LOGICAL-c499t-e391d4aa85236f6d1941e60d900d3e77b9c79100fa3bbafdad41bf5d00f2ae6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1081-1206(10)62580-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=855020$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11152174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paramo, Berta Juliade</creatorcontrib><creatorcontrib>Gancedo, Santiago Quirce</creatorcontrib><creatorcontrib>Cuevas, Manuela</creatorcontrib><creatorcontrib>Camo, Ignacio Perez</creatorcontrib><creatorcontrib>Martin, Jose A.</creatorcontrib><creatorcontrib>Cosmes, Eloy Losada</creatorcontrib><title>Paracetamol (acetaminophen) hypersensitivity</title><title>Annals of allergy, asthma, & immunology</title><addtitle>Ann Allergy Asthma Immunol</addtitle><description>Acetaminophen (paracetamol) is an analgesic antipyretic drug with no antiinflammatory effects and is widely used worldwide. Earlier clinical studies reported IgE-mediated adverse reactions to acetaminophen, but in vivo and in vitro tests have been inconclusive.
We propose to demonstrate an IgE-mediated mechanism in four patients with adverse reactions to acetaminophen (paracetamol). Tolerance to aspirin and other nonsteroidal antiinflammatory drugs are present in all patients.
We studied four patients with anaphylactic reactions to acetaminophen who tolerated aspirin and other nonsteroidal antiinflammatory drugs. Skin tests, oral challenges and immunoassay for allergen-specific IgE antibodies with acetaminophen were performed in all patients.
All patients tolerated the aspirin oral challenge without adverse effects. In contrast, the oral challenge with acetaminophen produced adverse effects in all patients. Skin tests with acetaminophen were positive in two patients (3-mm wheal and flare) and IgE antibodies acetaminophen were detected in serum from two patients.
We describe four patients with adverse reactions to acetaminophen but with tolerance to aspirin and other nonsteroidal antiinflammatory drugs. Skin tests, oral challenges, and serum IgE results with acetaminophen suggest that an IgE-mediated mechanism is responsible for these reactions.</description><subject>Acetaminophen - adverse effects</subject><subject>Adult</subject><subject>Aged</subject><subject>Analgesics, Non-Narcotic - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Drug Hypersensitivity - etiology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - chemically induced</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paramo, Berta Juliade</creatorcontrib><creatorcontrib>Gancedo, Santiago Quirce</creatorcontrib><creatorcontrib>Cuevas, Manuela</creatorcontrib><creatorcontrib>Camo, Ignacio Perez</creatorcontrib><creatorcontrib>Martin, Jose A.</creatorcontrib><creatorcontrib>Cosmes, Eloy Losada</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Annals of allergy, asthma, & immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paramo, Berta Juliade</au><au>Gancedo, Santiago Quirce</au><au>Cuevas, Manuela</au><au>Camo, Ignacio Perez</au><au>Martin, Jose A.</au><au>Cosmes, Eloy Losada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paracetamol (acetaminophen) hypersensitivity</atitle><jtitle>Annals of allergy, asthma, & immunology</jtitle><addtitle>Ann Allergy Asthma Immunol</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>85</volume><issue>6</issue><spage>508</spage><epage>511</epage><pages>508-511</pages><issn>1081-1206</issn><eissn>1534-4436</eissn><coden>ANAEA3</coden><abstract>Acetaminophen (paracetamol) is an analgesic antipyretic drug with no antiinflammatory effects and is widely used worldwide. Earlier clinical studies reported IgE-mediated adverse reactions to acetaminophen, but in vivo and in vitro tests have been inconclusive.
We propose to demonstrate an IgE-mediated mechanism in four patients with adverse reactions to acetaminophen (paracetamol). Tolerance to aspirin and other nonsteroidal antiinflammatory drugs are present in all patients.
We studied four patients with anaphylactic reactions to acetaminophen who tolerated aspirin and other nonsteroidal antiinflammatory drugs. Skin tests, oral challenges and immunoassay for allergen-specific IgE antibodies with acetaminophen were performed in all patients.
All patients tolerated the aspirin oral challenge without adverse effects. In contrast, the oral challenge with acetaminophen produced adverse effects in all patients. Skin tests with acetaminophen were positive in two patients (3-mm wheal and flare) and IgE antibodies acetaminophen were detected in serum from two patients.
We describe four patients with adverse reactions to acetaminophen but with tolerance to aspirin and other nonsteroidal antiinflammatory drugs. Skin tests, oral challenges, and serum IgE results with acetaminophen suggest that an IgE-mediated mechanism is responsible for these reactions.</abstract><cop>McLean, VA</cop><pub>Elsevier Inc</pub><pmid>11152174</pmid><doi>10.1016/S1081-1206(10)62580-X</doi><tpages>4</tpages></addata></record> |
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| ispartof | Annals of allergy, asthma, & immunology, 2000-12, Vol.85 (6), p.508-511 |
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| subjects | Acetaminophen - adverse effects Adult Aged Analgesics, Non-Narcotic - adverse effects Biological and medical sciences Drug Hypersensitivity - etiology Drug toxicity and drugs side effects treatment Female Humans Hypersensitivity, Immediate - chemically induced Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Skin Tests |
| title | Paracetamol (acetaminophen) hypersensitivity |
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