Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes

Micronucleus (MN) induction in erythrocytes of multiple intestinal neoplasia (Min) mice with heterozygous Apc mutation was measured after s.c. injections of acrylamide, glycidamide, 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and colchicine, and compared with wild-type (wt) mice. Since A...

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Veröffentlicht in:	Mutation research 2005-02, Vol.580 (1), p.111-118
Hauptverfasser:	Husøy, T., Abramsson-Zetterberg, L., Ølstørn, H.B., Paulsen, J.E., Alexander, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide Acrylamide - toxicity Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli Protein - genetics Animals Colchicine Colchicine - toxicity Cytarabine - pharmacology DNA Adducts - metabolism Epoxy Compounds - toxicity Erythrocytes - drug effects Female Flow Cytometry Glycidamide Hydroxyurea - pharmacology Imidazoles - toxicity Injections, Subcutaneous Male Mice Mice, Inbred C57BL Mice, Mutant Strains Micronuclei Micronuclei, Chromosome-Defective - chemically induced Micronucleus Tests Min-mouse Mutagens - toxicity PhIP
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