Responses to the major acrolein-derived deoxyguanosine adduct in Escherichia coli

Acrolein, a reactive alpha,beta-unsaturated aldehyde found ubiquitously in the environment and formed endogenously in mammalian cells, reacts with DNA to form an exocyclic DNA adduct, 3H-8-hydroxy-3-(beta-D-2'-deoxyribofuranosyl)-5,6,7,8-tetrahydropyrido[3,2-a]purine-9-one (gamma-OH-PdG). The c...

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Veröffentlicht in:	The Journal of biological chemistry 2001-03, Vol.276 (12), p.9071-9076
Hauptverfasser:	Yang, I Y, Hossain, M, Miller, H, Khullar, S, Johnson, F, Grollman, A, Moriya, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein Acrolein - metabolism Acrolein - pharmacology Base Sequence Catalysis deoxyguanosine Deoxyguanosine - metabolism dinB gene DNA Polymerase I - metabolism DNA Polymerase III - metabolism DNA Primers DNA Repair DNA Replication - drug effects DNA, Bacterial - biosynthesis DNA, Bacterial - drug effects DNA, Bacterial - metabolism DrecA protein Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Molecular Sequence Data polB gene recA gene recA protein Recombination, Genetic SOS response umuC gene umuD gene uvrA protein
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