Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG
Depletion of oxygen triggers the shift-down of Mycobacterium bovis BCG to a state of dormancy. Bacilli in their dormant state are resistant to standard anti-mycobacterials. The nitroimidazole metronidazole was the first compound identified to show bactericidal activity against dormant tubercle bacil...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2000-12, Vol.46 (6), p.917-919 |
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| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 46 |
| creator | Murugasu-Oei, Bernadette Dick, Thomas |
| description | Depletion of oxygen triggers the shift-down of Mycobacterium bovis BCG to a state of dormancy. Bacilli in their dormant state are resistant to standard anti-mycobacterials. The nitroimidazole metronidazole was the first compound identified to show bactericidal activity against dormant tubercle bacilli. In contrast to metronidazole's selective toxicity for dormant bacilli, we report here that the nitrofurans nitrofurantoin, furaltadone and nitrofurazone showed bactericidal activity against dormant and growing bacteria. Importantly, the bactericidal effect of nitrofurans on dormant bacilli was 35- to 250-fold higher compared with metronidazole. |
| doi_str_mv | 10.1093/jac/46.6.917 |
| format | Article |
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Antimicrob. Chemother</addtitle><description>Depletion of oxygen triggers the shift-down of Mycobacterium bovis BCG to a state of dormancy. Bacilli in their dormant state are resistant to standard anti-mycobacterials. The nitroimidazole metronidazole was the first compound identified to show bactericidal activity against dormant tubercle bacilli. In contrast to metronidazole's selective toxicity for dormant bacilli, we report here that the nitrofurans nitrofurantoin, furaltadone and nitrofurazone showed bactericidal activity against dormant and growing bacteria. Importantly, the bactericidal effect of nitrofurans on dormant bacilli was 35- to 250-fold higher compared with metronidazole.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>furaltadone</subject><subject>Medical sciences</subject><subject>Metronidazole - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Mycobacterium bovis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Nitrofurans - pharmacology</subject><subject>nitrofurantoin</subject><subject>Nitrofurantoin - pharmacology</subject><subject>nitrofurazone</subject><subject>Oxazolidinones - pharmacology</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>furaltadone</topic><topic>Medical sciences</topic><topic>Metronidazole - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Mycobacterium bovis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Nitrofurans - pharmacology</topic><topic>nitrofurantoin</topic><topic>Nitrofurantoin - pharmacology</topic><topic>nitrofurazone</topic><topic>Oxazolidinones - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murugasu-Oei, Bernadette</creatorcontrib><creatorcontrib>Dick, Thomas</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murugasu-Oei, Bernadette</au><au>Dick, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J. Antimicrob. Chemother</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>46</volume><issue>6</issue><spage>917</spage><epage>919</epage><pages>917-919</pages><issn>0305-7453</issn><issn>1460-2091</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Depletion of oxygen triggers the shift-down of Mycobacterium bovis BCG to a state of dormancy. Bacilli in their dormant state are resistant to standard anti-mycobacterials. The nitroimidazole metronidazole was the first compound identified to show bactericidal activity against dormant tubercle bacilli. In contrast to metronidazole's selective toxicity for dormant bacilli, we report here that the nitrofurans nitrofurantoin, furaltadone and nitrofurazone showed bactericidal activity against dormant and growing bacteria. 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| ispartof | Journal of antimicrobial chemotherapy, 2000-12, Vol.46 (6), p.917-919 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences furaltadone Medical sciences Metronidazole - pharmacology Microbial Sensitivity Tests Mycobacterium bovis Mycobacterium tuberculosis - drug effects Nitrofurans - pharmacology nitrofurantoin Nitrofurantoin - pharmacology nitrofurazone Oxazolidinones - pharmacology Pharmacology. Drug treatments |
| title | Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG |
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