The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles

In 1973, a technique of administering 6-hydroxydopamine (2,4,5-trihydroxyphenylethylamine) intracisternally to neonate rats was introduced to selectively reduce brain dopamine (neonate-lesioned rat). This neonate treatment proved unique when compared to rats lesioned as adults with 6-hydroxydopamine...

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Veröffentlicht in:	Brain Research Reviews 2005-02, Vol.48 (1), p.57-73
Hauptverfasser:	Breese, George R., Knapp, Darin J., Criswell, Hugh E., Moy, Sheryl S., Papadeas, Sophia T., Blake, Bonita L.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Age Factors Animals Animals, Newborn Behavioral sensitization Biological and medical sciences Brain - metabolism Brain - physiopathology Brain Chemistry - drug effects Brain Chemistry - physiology D 1-dopamine receptors Disease Models, Animal Dopamine - metabolism Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Medical sciences Mental Disorders - metabolism Mental Disorders - physiopathology Neonate dopamine lesion Nervous system involvement in other diseases. Miscellaneous Neurology Neurology - methods Neurology - trends NMDA hypofunction NMDA receptor antagonists Oxidopamine - pharmacology Rats Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Self-injurious behavior Serotonin hyperinnervation Sympatholytics - pharmacology
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