Structure, morphology and properties of genipin-crosslinked carboxymethylchitosan porous membranes
•Genipin cross-linked carboxymethylchitosan membranes were prepared.•Such membranes are able to adsorb as much as 500–1700% its weight in water.•Lightly cross-linked membranes presented superior mechanical properties.•Lightly cross-linked membranes are more susceptible to lysozyme degradation. Highl...
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| Veröffentlicht in: | Carbohydrate polymers 2016-06, Vol.143, p.155-163 |
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| container_title | Carbohydrate polymers |
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| creator | Fiamingo, Anderson Campana-Filho, Sergio Paulo |
| description | •Genipin cross-linked carboxymethylchitosan membranes were prepared.•Such membranes are able to adsorb as much as 500–1700% its weight in water.•Lightly cross-linked membranes presented superior mechanical properties.•Lightly cross-linked membranes are more susceptible to lysozyme degradation.
Highly porous genipin cross-linked membranes of carboxymethylchitosan exhibiting different crosslinking degree (3% |
| doi_str_mv | 10.1016/j.carbpol.2016.02.016 |
| format | Article |
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Highly porous genipin cross-linked membranes of carboxymethylchitosan exhibiting different crosslinking degree (3%<CrD¯ < 18%) were produced by using different concentrations of genipin and carboxymethylchitosan possessing high, medium or low molecular weight. The membranes were able to adsorb high amounts of PBS and presented high ultimate tensile strength and elongation-at-break the lower the crosslinking degree and the higher the molecular of the parent carboxymethylchitosan. Particularly, the membrane prepared from high molecular weight carboxymethylchitosan displayed higher swelling ratio (17.5g/g), ultimate tensile strength (≥300kPa) and elongation-at-break (≥65%). The susceptibility to lysozyme degradation depends only on the crosslinking degree of the membranes, the degradation rate being faster the lower the crosslinking degree. The preparation of lightly genipin cross-linked carboxymethylchitosan membranes displaying appropriated properties to fulfill specific applications as biomaterials is envisaged by using high molecular weight carboxymethylchitosan.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2016.02.016</identifier><identifier>PMID: 27083355</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Carboxymethylchitosan ; Chitosan ; Chitosan - analogs & derivatives ; Chitosan - chemistry ; Chitosan - isolation & purification ; Cross-linked membrane ; Cross-Linking Reagents - chemistry ; Decapodiformes ; Elastic Modulus ; Genipin ; Iridoids - chemistry ; Membranes, Artificial ; Muramidase - metabolism ; Porosity ; Proton Magnetic Resonance Spectroscopy ; Spectroscopy, Fourier Transform Infrared ; Tensile Strength ; Viscosity</subject><ispartof>Carbohydrate polymers, 2016-06, Vol.143, p.155-163</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-d660d4f38b1868b24a55d199dd6effe04c8e484722346dc2bab4767adde764653</citedby><cites>FETCH-LOGICAL-c402t-d660d4f38b1868b24a55d199dd6effe04c8e484722346dc2bab4767adde764653</cites><orcidid>0000-0002-3437-2617</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0144861716300728$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27083355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fiamingo, Anderson</creatorcontrib><creatorcontrib>Campana-Filho, Sergio Paulo</creatorcontrib><title>Structure, morphology and properties of genipin-crosslinked carboxymethylchitosan porous membranes</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>•Genipin cross-linked carboxymethylchitosan membranes were prepared.•Such membranes are able to adsorb as much as 500–1700% its weight in water.•Lightly cross-linked membranes presented superior mechanical properties.•Lightly cross-linked membranes are more susceptible to lysozyme degradation.
Highly porous genipin cross-linked membranes of carboxymethylchitosan exhibiting different crosslinking degree (3%<CrD¯ < 18%) were produced by using different concentrations of genipin and carboxymethylchitosan possessing high, medium or low molecular weight. The membranes were able to adsorb high amounts of PBS and presented high ultimate tensile strength and elongation-at-break the lower the crosslinking degree and the higher the molecular of the parent carboxymethylchitosan. Particularly, the membrane prepared from high molecular weight carboxymethylchitosan displayed higher swelling ratio (17.5g/g), ultimate tensile strength (≥300kPa) and elongation-at-break (≥65%). The susceptibility to lysozyme degradation depends only on the crosslinking degree of the membranes, the degradation rate being faster the lower the crosslinking degree. The preparation of lightly genipin cross-linked carboxymethylchitosan membranes displaying appropriated properties to fulfill specific applications as biomaterials is envisaged by using high molecular weight carboxymethylchitosan.</description><subject>Animals</subject><subject>Carboxymethylchitosan</subject><subject>Chitosan</subject><subject>Chitosan - analogs & derivatives</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - isolation & purification</subject><subject>Cross-linked membrane</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Decapodiformes</subject><subject>Elastic Modulus</subject><subject>Genipin</subject><subject>Iridoids - chemistry</subject><subject>Membranes, Artificial</subject><subject>Muramidase - metabolism</subject><subject>Porosity</subject><subject>Proton Magnetic Resonance Spectroscopy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Tensile Strength</subject><subject>Viscosity</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUMtOwzAQtBAISuETQDlyIMF2HMc9IVTxkpA4AGfLsTetSxIHO0H073Fp4cpeRivN7M4MQmcEZwQTfrXKtPJV75qMxjXDNIuwhyZElLOU5IztowkmjKWCk_IIHYewwnE4wYfoiJZY5HlRTFD1MvhRD6OHy6R1vl-6xi3WiepM0nvXgx8shMTVyQI629su1d6F0NjuHUyyceC-1i0My3Wjl3ZwQXVJ77wbQ9JCW3nVQThBB7VqApzucIre7m5f5w_p0_P94_zmKdUM0yE1nGPD6lxURHBRUaaKwpDZzBgOdQ2YaQFMsJLSnHGjaaUqVvJSGQMlZ7zIp-hiezca_xghDLK1QUPTRBPRkCSlIAXLWc4jtdhSf9J4qGXvbav8WhIsN_XKldzVKzf1SkxlhKg7370YqxbMn-q3z0i43hIgBv204GXQFjoNxnrQgzTO_vPiGx8VkR0</recordid><startdate>20160605</startdate><enddate>20160605</enddate><creator>Fiamingo, Anderson</creator><creator>Campana-Filho, Sergio Paulo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3437-2617</orcidid></search><sort><creationdate>20160605</creationdate><title>Structure, morphology and properties of genipin-crosslinked carboxymethylchitosan porous membranes</title><author>Fiamingo, Anderson ; Campana-Filho, Sergio Paulo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-d660d4f38b1868b24a55d199dd6effe04c8e484722346dc2bab4767adde764653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Carboxymethylchitosan</topic><topic>Chitosan</topic><topic>Chitosan - analogs & derivatives</topic><topic>Chitosan - chemistry</topic><topic>Chitosan - isolation & purification</topic><topic>Cross-linked membrane</topic><topic>Cross-Linking Reagents - chemistry</topic><topic>Decapodiformes</topic><topic>Elastic Modulus</topic><topic>Genipin</topic><topic>Iridoids - chemistry</topic><topic>Membranes, Artificial</topic><topic>Muramidase - metabolism</topic><topic>Porosity</topic><topic>Proton Magnetic Resonance Spectroscopy</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Tensile Strength</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fiamingo, Anderson</creatorcontrib><creatorcontrib>Campana-Filho, Sergio Paulo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fiamingo, Anderson</au><au>Campana-Filho, Sergio Paulo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure, morphology and properties of genipin-crosslinked carboxymethylchitosan porous membranes</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2016-06-05</date><risdate>2016</risdate><volume>143</volume><spage>155</spage><epage>163</epage><pages>155-163</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>•Genipin cross-linked carboxymethylchitosan membranes were prepared.•Such membranes are able to adsorb as much as 500–1700% its weight in water.•Lightly cross-linked membranes presented superior mechanical properties.•Lightly cross-linked membranes are more susceptible to lysozyme degradation.
Highly porous genipin cross-linked membranes of carboxymethylchitosan exhibiting different crosslinking degree (3%<CrD¯ < 18%) were produced by using different concentrations of genipin and carboxymethylchitosan possessing high, medium or low molecular weight. The membranes were able to adsorb high amounts of PBS and presented high ultimate tensile strength and elongation-at-break the lower the crosslinking degree and the higher the molecular of the parent carboxymethylchitosan. Particularly, the membrane prepared from high molecular weight carboxymethylchitosan displayed higher swelling ratio (17.5g/g), ultimate tensile strength (≥300kPa) and elongation-at-break (≥65%). The susceptibility to lysozyme degradation depends only on the crosslinking degree of the membranes, the degradation rate being faster the lower the crosslinking degree. The preparation of lightly genipin cross-linked carboxymethylchitosan membranes displaying appropriated properties to fulfill specific applications as biomaterials is envisaged by using high molecular weight carboxymethylchitosan.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27083355</pmid><doi>10.1016/j.carbpol.2016.02.016</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3437-2617</orcidid></addata></record> |
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| ispartof | Carbohydrate polymers, 2016-06, Vol.143, p.155-163 |
| issn | 0144-8617 1879-1344 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Carboxymethylchitosan Chitosan Chitosan - analogs & derivatives Chitosan - chemistry Chitosan - isolation & purification Cross-linked membrane Cross-Linking Reagents - chemistry Decapodiformes Elastic Modulus Genipin Iridoids - chemistry Membranes, Artificial Muramidase - metabolism Porosity Proton Magnetic Resonance Spectroscopy Spectroscopy, Fourier Transform Infrared Tensile Strength Viscosity |
| title | Structure, morphology and properties of genipin-crosslinked carboxymethylchitosan porous membranes |
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