Value of Early Check-Up of Carbohydrate Antigen 19-9 Levels for Pancreatic Cancer Screening in Asymptomatic New-Onset Diabetic Patients
We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients. Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 200...
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| Veröffentlicht in: | Pancreas 2016-05, Vol.45 (5), p.730-734 |
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| creator | Choe, Jung Wan Kim, Jae Seon Kim, Hyo Jung Hwang, Soon Young Joo, Moon Kyung Lee, Beom Jae Kim, Ji Hoon Yeon, Jong Eun Park, Jong-Jae Byun, Kwan Soo Bak, Young-Tae |
| description | We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients.
Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013.
In total, 2363 asymptomatic diabetic patients with CA 19-9 measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease.
Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years. |
| doi_str_mv | 10.1097/mpa.0000000000000538 |
| format | Article |
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Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013.
In total, 2363 asymptomatic diabetic patients with CA 19-9 measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease.
Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/mpa.0000000000000538</identifier><identifier>PMID: 26646277</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Biomarkers, Tumor - blood ; Blood Glucose - metabolism ; CA-19-9 Antigen - blood ; Carcinoembryonic Antigen - blood ; Diabetes Mellitus - blood ; Diabetes Mellitus - diagnosis ; Early Detection of Cancer - methods ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - diagnosis ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity</subject><ispartof>Pancreas, 2016-05, Vol.45 (5), p.730-734</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-3c4d2220c4b08912ae3e9db19ab25a99fd6c254ad0a4e602e682f38ba1a0d0513</citedby><cites>FETCH-LOGICAL-c373t-3c4d2220c4b08912ae3e9db19ab25a99fd6c254ad0a4e602e682f38ba1a0d0513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26646277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choe, Jung Wan</creatorcontrib><creatorcontrib>Kim, Jae Seon</creatorcontrib><creatorcontrib>Kim, Hyo Jung</creatorcontrib><creatorcontrib>Hwang, Soon Young</creatorcontrib><creatorcontrib>Joo, Moon Kyung</creatorcontrib><creatorcontrib>Lee, Beom Jae</creatorcontrib><creatorcontrib>Kim, Ji Hoon</creatorcontrib><creatorcontrib>Yeon, Jong Eun</creatorcontrib><creatorcontrib>Park, Jong-Jae</creatorcontrib><creatorcontrib>Byun, Kwan Soo</creatorcontrib><creatorcontrib>Bak, Young-Tae</creatorcontrib><title>Value of Early Check-Up of Carbohydrate Antigen 19-9 Levels for Pancreatic Cancer Screening in Asymptomatic New-Onset Diabetic Patients</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients.
Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013.
In total, 2363 asymptomatic diabetic patients with CA 19-9 measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease.
Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.</description><subject>Aged</subject><subject>Biomarkers, Tumor - blood</subject><subject>Blood Glucose - metabolism</subject><subject>CA-19-9 Antigen - blood</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Early Detection of Cancer - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUclOwzAQtRAIyvIHCPnIJeAlie1jVcoiFajEco0mzgQCiRPsFNQv4LdJ2YSYy2jevDcjvUfIPmdHnBl13HRwxP5WIvUaGfFEplGshV4nI6Z1Ekmu1BbZDuGJMa5kYjbJlkjTOBVKjcj7PdQLpG1Jp-DrJZ08on2O7roVMgGft4_LwkOPdOz66gEd5SYydIavWAdatp7OwVmP0Fd24DuLnt4MM7rKPdDK0XFYNl3fNp-EK3yLrl3Anp5UkOMKmg8LdH3YJRsl1AH3vvsOuTud3k7Oo9n12cVkPIusVLKPpI0LIQSzcc604QJQoilybiAXCRhTFqkVSQwFgxhTJjDVopQ6Bw6sYAmXO-Tw627n25cFhj5rqmCxrsFhuwgZV3pwUEulBmr8RbW-DcFjmXW-asAvM86yVQTZ5Xyc_Y9gkB18f1jkDRa_oh_P5Qf93IHn</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Choe, Jung Wan</creator><creator>Kim, Jae Seon</creator><creator>Kim, Hyo Jung</creator><creator>Hwang, Soon Young</creator><creator>Joo, Moon Kyung</creator><creator>Lee, Beom Jae</creator><creator>Kim, Ji Hoon</creator><creator>Yeon, Jong Eun</creator><creator>Park, Jong-Jae</creator><creator>Byun, Kwan Soo</creator><creator>Bak, Young-Tae</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Value of Early Check-Up of Carbohydrate Antigen 19-9 Levels for Pancreatic Cancer Screening in Asymptomatic New-Onset Diabetic Patients</title><author>Choe, Jung Wan ; Kim, Jae Seon ; Kim, Hyo Jung ; Hwang, Soon Young ; Joo, Moon Kyung ; Lee, Beom Jae ; Kim, Ji Hoon ; Yeon, Jong Eun ; Park, Jong-Jae ; Byun, Kwan Soo ; Bak, Young-Tae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-3c4d2220c4b08912ae3e9db19ab25a99fd6c254ad0a4e602e682f38ba1a0d0513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - blood</topic><topic>Blood Glucose - metabolism</topic><topic>CA-19-9 Antigen - blood</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - diagnosis</topic><topic>Early Detection of Cancer - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choe, Jung Wan</creatorcontrib><creatorcontrib>Kim, Jae Seon</creatorcontrib><creatorcontrib>Kim, Hyo Jung</creatorcontrib><creatorcontrib>Hwang, Soon Young</creatorcontrib><creatorcontrib>Joo, Moon Kyung</creatorcontrib><creatorcontrib>Lee, Beom Jae</creatorcontrib><creatorcontrib>Kim, Ji Hoon</creatorcontrib><creatorcontrib>Yeon, Jong Eun</creatorcontrib><creatorcontrib>Park, Jong-Jae</creatorcontrib><creatorcontrib>Byun, Kwan Soo</creatorcontrib><creatorcontrib>Bak, Young-Tae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choe, Jung Wan</au><au>Kim, Jae Seon</au><au>Kim, Hyo Jung</au><au>Hwang, Soon Young</au><au>Joo, Moon Kyung</au><au>Lee, Beom Jae</au><au>Kim, Ji Hoon</au><au>Yeon, Jong Eun</au><au>Park, Jong-Jae</au><au>Byun, Kwan Soo</au><au>Bak, Young-Tae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of Early Check-Up of Carbohydrate Antigen 19-9 Levels for Pancreatic Cancer Screening in Asymptomatic New-Onset Diabetic Patients</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>45</volume><issue>5</issue><spage>730</spage><epage>734</epage><pages>730-734</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><abstract>We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients.
Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013.
In total, 2363 asymptomatic diabetic patients with CA 19-9 measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease.
Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.</abstract><cop>United States</cop><pmid>26646277</pmid><doi>10.1097/mpa.0000000000000538</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Biomarkers, Tumor - blood Blood Glucose - metabolism CA-19-9 Antigen - blood Carcinoembryonic Antigen - blood Diabetes Mellitus - blood Diabetes Mellitus - diagnosis Early Detection of Cancer - methods Female Humans Logistic Models Male Middle Aged Multivariate Analysis Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Reproducibility of Results Retrospective Studies Sensitivity and Specificity |
| title | Value of Early Check-Up of Carbohydrate Antigen 19-9 Levels for Pancreatic Cancer Screening in Asymptomatic New-Onset Diabetic Patients |
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