PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer
Among patients who received chemotherapy for advanced head and neck cancer, 2-year overall survival was 81.5% in the group assigned to immediate radical neck dissection and 84.9% in the group assigned to positron-emission tomographic–computed tomographic surveillance. Chemoradiotherapy has become a...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2016-04, Vol.374 (15), p.1444-1454 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1454 |
|---|---|
| container_issue | 15 |
| container_start_page | 1444 |
| container_title | The New England journal of medicine |
| container_volume | 374 |
| creator | Mehanna, Hisham Wong, Wai-Lup McConkey, Christopher C Rahman, Joy K Robinson, Max Hartley, Andrew G.J Nutting, Christopher Powell, Ned Al-Booz, Hoda Robinson, Martin Junor, Elizabeth Rizwanullah, Mohammed V. von Zeidler, Sandra Wieshmann, Hulya Hulme, Claire Smith, Alison F Hall, Peter Dunn, Janet |
| description | Among patients who received chemotherapy for advanced head and neck cancer, 2-year overall survival was 81.5% in the group assigned to immediate radical neck dissection and 84.9% in the group assigned to positron-emission tomographic–computed tomographic surveillance.
Chemoradiotherapy has become a mainstay of primary treatment in patients with squamous-cell carcinoma of the head and neck. However, there are wide variations in the management of advanced nodal disease (stage N2 or N3) in these patients because of the lack of prospective, randomized, controlled trials.
1
,
2
Retrospective studies showed persistent disease on histopathological examination of nodes in up to 40% of patients who underwent neck dissection after chemoradiotherapy
3
and some evidence of a significant survival advantage associated with planned neck dissection.
4
,
5
However, owing to improvements in cross-sectional imaging, consistently low rates of recurrence ( |
| doi_str_mv | 10.1056/NEJMoa1514493 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1781535780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4023526261</sourcerecordid><originalsourceid>FETCH-LOGICAL-m199t-49f008ff7643602e1322fef8baa0a17026d9e00eece114e10063be37ba5c51403</originalsourceid><addsrcrecordid>eNpd0E1Lw0AQBuBFFFurR6-yIIKX6OxHssmxxGrVWgXredkkE0jtJjXbFPz3bqwedC4Dw8Mw8xJyyuCKQRhdzycPT41hIZMyEXtkyEIhAikh2idDAB4HUiViQI6cW4IvJpNDMuAKQIUqHpLHl8kiSBf0tWu3WK1Wps6RbrF1naNzzN_pTeUc5puqqWlV03Gx7UVBp2gKaupih9J-2B6Tg9KsHJ789BF5u50s0mkwe767T8ezwLIk2QQyKQHislSRFBFwZILzEss4MwYMU8CjIkEAxBwZk8gAIpGhUJkJc_8miBG53O1dt81Hh26jbeVy7I_HpnOaqdin4N_r6fk_umy6tvbXfSsOYcgjr85-VJdZLPS6raxpP_VvTB5c7IC1Tte4tJqB7uPXf-IXX6jycZk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781205526</pqid></control><display><type>article</type><title>PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>New England Journal of Medicine</source><creator>Mehanna, Hisham ; Wong, Wai-Lup ; McConkey, Christopher C ; Rahman, Joy K ; Robinson, Max ; Hartley, Andrew G.J ; Nutting, Christopher ; Powell, Ned ; Al-Booz, Hoda ; Robinson, Martin ; Junor, Elizabeth ; Rizwanullah, Mohammed ; V. von Zeidler, Sandra ; Wieshmann, Hulya ; Hulme, Claire ; Smith, Alison F ; Hall, Peter ; Dunn, Janet</creator><creatorcontrib>Mehanna, Hisham ; Wong, Wai-Lup ; McConkey, Christopher C ; Rahman, Joy K ; Robinson, Max ; Hartley, Andrew G.J ; Nutting, Christopher ; Powell, Ned ; Al-Booz, Hoda ; Robinson, Martin ; Junor, Elizabeth ; Rizwanullah, Mohammed ; V. von Zeidler, Sandra ; Wieshmann, Hulya ; Hulme, Claire ; Smith, Alison F ; Hall, Peter ; Dunn, Janet ; PET-NECK Trial Management Group</creatorcontrib><description>Among patients who received chemotherapy for advanced head and neck cancer, 2-year overall survival was 81.5% in the group assigned to immediate radical neck dissection and 84.9% in the group assigned to positron-emission tomographic–computed tomographic surveillance.
Chemoradiotherapy has become a mainstay of primary treatment in patients with squamous-cell carcinoma of the head and neck. However, there are wide variations in the management of advanced nodal disease (stage N2 or N3) in these patients because of the lack of prospective, randomized, controlled trials.
1
,
2
Retrospective studies showed persistent disease on histopathological examination of nodes in up to 40% of patients who underwent neck dissection after chemoradiotherapy
3
and some evidence of a significant survival advantage associated with planned neck dissection.
4
,
5
However, owing to improvements in cross-sectional imaging, consistently low rates of recurrence (<10%) have been reported among . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1514493</identifier><identifier>PMID: 27007578</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Cancer therapies ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - surgery ; Carcinoma, Squamous Cell - therapy ; Chemoradiotherapy ; Clinical trials ; Computed tomography ; Dissection ; Female ; Follow-Up Studies ; Head & neck cancer ; Head and Neck Neoplasms - diagnosis ; Head and Neck Neoplasms - surgery ; Head and Neck Neoplasms - therapy ; Human papillomavirus ; Humans ; Intention to Treat Analysis ; Kaplan-Meier Estimate ; Lymphatic Metastasis - diagnosis ; Male ; Middle Aged ; Neck ; Neck Dissection ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Oropharyngeal cancer ; p16 Protein ; Patients ; Positron emission tomography ; Prospective Studies ; Quality of Life ; Squamous cell carcinoma ; Surgery ; Survival Rate ; Throat cancer ; Tomography ; Tomography, X-Ray Computed</subject><ispartof>The New England journal of medicine, 2016-04, Vol.374 (15), p.1444-1454</ispartof><rights>Copyright © 2016 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1514493$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1514493$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27007578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehanna, Hisham</creatorcontrib><creatorcontrib>Wong, Wai-Lup</creatorcontrib><creatorcontrib>McConkey, Christopher C</creatorcontrib><creatorcontrib>Rahman, Joy K</creatorcontrib><creatorcontrib>Robinson, Max</creatorcontrib><creatorcontrib>Hartley, Andrew G.J</creatorcontrib><creatorcontrib>Nutting, Christopher</creatorcontrib><creatorcontrib>Powell, Ned</creatorcontrib><creatorcontrib>Al-Booz, Hoda</creatorcontrib><creatorcontrib>Robinson, Martin</creatorcontrib><creatorcontrib>Junor, Elizabeth</creatorcontrib><creatorcontrib>Rizwanullah, Mohammed</creatorcontrib><creatorcontrib>V. von Zeidler, Sandra</creatorcontrib><creatorcontrib>Wieshmann, Hulya</creatorcontrib><creatorcontrib>Hulme, Claire</creatorcontrib><creatorcontrib>Smith, Alison F</creatorcontrib><creatorcontrib>Hall, Peter</creatorcontrib><creatorcontrib>Dunn, Janet</creatorcontrib><creatorcontrib>PET-NECK Trial Management Group</creatorcontrib><title>PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Among patients who received chemotherapy for advanced head and neck cancer, 2-year overall survival was 81.5% in the group assigned to immediate radical neck dissection and 84.9% in the group assigned to positron-emission tomographic–computed tomographic surveillance.
Chemoradiotherapy has become a mainstay of primary treatment in patients with squamous-cell carcinoma of the head and neck. However, there are wide variations in the management of advanced nodal disease (stage N2 or N3) in these patients because of the lack of prospective, randomized, controlled trials.
1
,
2
Retrospective studies showed persistent disease on histopathological examination of nodes in up to 40% of patients who underwent neck dissection after chemoradiotherapy
3
and some evidence of a significant survival advantage associated with planned neck dissection.
4
,
5
However, owing to improvements in cross-sectional imaging, consistently low rates of recurrence (<10%) have been reported among . . .</description><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Chemoradiotherapy</subject><subject>Clinical trials</subject><subject>Computed tomography</subject><subject>Dissection</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Intention to Treat Analysis</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Neck Dissection</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Oropharyngeal cancer</subject><subject>p16 Protein</subject><subject>Patients</subject><subject>Positron emission tomography</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Throat cancer</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0E1Lw0AQBuBFFFurR6-yIIKX6OxHssmxxGrVWgXredkkE0jtJjXbFPz3bqwedC4Dw8Mw8xJyyuCKQRhdzycPT41hIZMyEXtkyEIhAikh2idDAB4HUiViQI6cW4IvJpNDMuAKQIUqHpLHl8kiSBf0tWu3WK1Wps6RbrF1naNzzN_pTeUc5puqqWlV03Gx7UVBp2gKaupih9J-2B6Tg9KsHJ789BF5u50s0mkwe767T8ezwLIk2QQyKQHislSRFBFwZILzEss4MwYMU8CjIkEAxBwZk8gAIpGhUJkJc_8miBG53O1dt81Hh26jbeVy7I_HpnOaqdin4N_r6fk_umy6tvbXfSsOYcgjr85-VJdZLPS6raxpP_VvTB5c7IC1Tte4tJqB7uPXf-IXX6jycZk</recordid><startdate>20160414</startdate><enddate>20160414</enddate><creator>Mehanna, Hisham</creator><creator>Wong, Wai-Lup</creator><creator>McConkey, Christopher C</creator><creator>Rahman, Joy K</creator><creator>Robinson, Max</creator><creator>Hartley, Andrew G.J</creator><creator>Nutting, Christopher</creator><creator>Powell, Ned</creator><creator>Al-Booz, Hoda</creator><creator>Robinson, Martin</creator><creator>Junor, Elizabeth</creator><creator>Rizwanullah, Mohammed</creator><creator>V. von Zeidler, Sandra</creator><creator>Wieshmann, Hulya</creator><creator>Hulme, Claire</creator><creator>Smith, Alison F</creator><creator>Hall, Peter</creator><creator>Dunn, Janet</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160414</creationdate><title>PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer</title><author>Mehanna, Hisham ; Wong, Wai-Lup ; McConkey, Christopher C ; Rahman, Joy K ; Robinson, Max ; Hartley, Andrew G.J ; Nutting, Christopher ; Powell, Ned ; Al-Booz, Hoda ; Robinson, Martin ; Junor, Elizabeth ; Rizwanullah, Mohammed ; V. von Zeidler, Sandra ; Wieshmann, Hulya ; Hulme, Claire ; Smith, Alison F ; Hall, Peter ; Dunn, Janet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-m199t-49f008ff7643602e1322fef8baa0a17026d9e00eece114e10063be37ba5c51403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cancer therapies</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Chemoradiotherapy</topic><topic>Clinical trials</topic><topic>Computed tomography</topic><topic>Dissection</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Intention to Treat Analysis</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Neck Dissection</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Oropharyngeal cancer</topic><topic>p16 Protein</topic><topic>Patients</topic><topic>Positron emission tomography</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Throat cancer</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehanna, Hisham</creatorcontrib><creatorcontrib>Wong, Wai-Lup</creatorcontrib><creatorcontrib>McConkey, Christopher C</creatorcontrib><creatorcontrib>Rahman, Joy K</creatorcontrib><creatorcontrib>Robinson, Max</creatorcontrib><creatorcontrib>Hartley, Andrew G.J</creatorcontrib><creatorcontrib>Nutting, Christopher</creatorcontrib><creatorcontrib>Powell, Ned</creatorcontrib><creatorcontrib>Al-Booz, Hoda</creatorcontrib><creatorcontrib>Robinson, Martin</creatorcontrib><creatorcontrib>Junor, Elizabeth</creatorcontrib><creatorcontrib>Rizwanullah, Mohammed</creatorcontrib><creatorcontrib>V. von Zeidler, Sandra</creatorcontrib><creatorcontrib>Wieshmann, Hulya</creatorcontrib><creatorcontrib>Hulme, Claire</creatorcontrib><creatorcontrib>Smith, Alison F</creatorcontrib><creatorcontrib>Hall, Peter</creatorcontrib><creatorcontrib>Dunn, Janet</creatorcontrib><creatorcontrib>PET-NECK Trial Management Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehanna, Hisham</au><au>Wong, Wai-Lup</au><au>McConkey, Christopher C</au><au>Rahman, Joy K</au><au>Robinson, Max</au><au>Hartley, Andrew G.J</au><au>Nutting, Christopher</au><au>Powell, Ned</au><au>Al-Booz, Hoda</au><au>Robinson, Martin</au><au>Junor, Elizabeth</au><au>Rizwanullah, Mohammed</au><au>V. von Zeidler, Sandra</au><au>Wieshmann, Hulya</au><au>Hulme, Claire</au><au>Smith, Alison F</au><au>Hall, Peter</au><au>Dunn, Janet</au><aucorp>PET-NECK Trial Management Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2016-04-14</date><risdate>2016</risdate><volume>374</volume><issue>15</issue><spage>1444</spage><epage>1454</epage><pages>1444-1454</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Among patients who received chemotherapy for advanced head and neck cancer, 2-year overall survival was 81.5% in the group assigned to immediate radical neck dissection and 84.9% in the group assigned to positron-emission tomographic–computed tomographic surveillance.
Chemoradiotherapy has become a mainstay of primary treatment in patients with squamous-cell carcinoma of the head and neck. However, there are wide variations in the management of advanced nodal disease (stage N2 or N3) in these patients because of the lack of prospective, randomized, controlled trials.
1
,
2
Retrospective studies showed persistent disease on histopathological examination of nodes in up to 40% of patients who underwent neck dissection after chemoradiotherapy
3
and some evidence of a significant survival advantage associated with planned neck dissection.
4
,
5
However, owing to improvements in cross-sectional imaging, consistently low rates of recurrence (<10%) have been reported among . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>27007578</pmid><doi>10.1056/NEJMoa1514493</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2016-04, Vol.374 (15), p.1444-1454 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1781535780 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Cancer therapies Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - surgery Carcinoma, Squamous Cell - therapy Chemoradiotherapy Clinical trials Computed tomography Dissection Female Follow-Up Studies Head & neck cancer Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - surgery Head and Neck Neoplasms - therapy Human papillomavirus Humans Intention to Treat Analysis Kaplan-Meier Estimate Lymphatic Metastasis - diagnosis Male Middle Aged Neck Neck Dissection Neoplasm Recurrence, Local Neoplasm Staging Oropharyngeal cancer p16 Protein Patients Positron emission tomography Prospective Studies Quality of Life Squamous cell carcinoma Surgery Survival Rate Throat cancer Tomography Tomography, X-Ray Computed |
| title | PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T15%3A51%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PET-CT%20Surveillance%20versus%20Neck%20Dissection%20in%20Advanced%20Head%20and%20Neck%20Cancer&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Mehanna,%20Hisham&rft.aucorp=PET-NECK%20Trial%20Management%20Group&rft.date=2016-04-14&rft.volume=374&rft.issue=15&rft.spage=1444&rft.epage=1454&rft.pages=1444-1454&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMoa1514493&rft_dat=%3Cproquest_pubme%3E4023526261%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781205526&rft_id=info:pmid/27007578&rfr_iscdi=true |