Synthesis of Cyclohexane-Fused Isocoumarins via Cationic Palladium(II)-Catalyzed Cascade Cyclization Reaction of Alkyne-Tethered Carbonyl Compounds Initiated by Intramolecular Oxypalladation of Ester-Substituted Aryl Alkynes

A cationic Pd­(II)-catalyzed cascade cyclization reaction of alkyne-tethered carbonyl compounds was developed. This reaction is initiated by intramolecular oxypalladation of alkynes with an ester group followed by 1,2-addition of the formed C–Pd­(II) bond to the carbonyl group, providing a highly ef...

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Veröffentlicht in:	Journal of organic chemistry 2016-04, Vol.81 (8), p.3423-3429
Hauptverfasser:	Zhang, Jianbo, Han, Xiuling, Lu, Xiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Catalysis Cations - chemistry Cyclization Cyclohexanes - chemical synthesis Cyclohexanes - chemistry Esters Indoles - chemistry Isocoumarins - chemical synthesis Isocoumarins - chemistry Molecular Structure Palladium - chemistry
Online-Zugang:	Volltext
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