Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity

Polycyclic aromatic hydrocarbons (PAHs) (50 mg/kg, i.p.) selectively deplete mouse bone marrow (BM) hematopoietic cells through a process that is dependent on CYP1B1. 7,12-dimethylbenz(a)anthracene (DMBA), which forms greater amounts of dihydrodiol-epoxide-DNA adducts in BM, is much more effective i...

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Veröffentlicht in:	Toxicology and applied pharmacology 2005-02, Vol.202 (3), p.244-257
Hauptverfasser:	GALVAN, Noé, TESKE, Doug E, GUODONG ZHOU, MOORTHY, Bhagavatula, MACWILLIAMS, Peter S, CZUPRYNSKI, Charles J, JEFCOATE, Colin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Medical sciences Toxicology Tumors
Online-Zugang:	Volltext
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