The Myotonic Dystrophy Type 1 Triplet Repeat Sequence Induces Gross Deletions and Inversions

The capacity of (CTG·CAG)n and (GAA·TTC)n repeat tracts in plasmids to induce mutations in DNA flanking regions was evaluated in Escherichia coli. Long repeats of these sequences are involved in the etiology of myotonic dystrophy type 1 and Friedreich's ataxia, respectively. Long (CTG·CAG)n (wh...

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Veröffentlicht in:	The Journal of biological chemistry 2005-01, Vol.280 (2), p.941-952
Hauptverfasser:	Wojciechowska, Marzena, Bacolla, Albino, Larson, Jacquelynn E., Wells, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Chromosome Breakage - genetics Chromosome Deletion Chromosome Inversion - genetics DNA, Bacterial - genetics Escherichia coli Escherichia coli - genetics Friedreich Ataxia - genetics Genes, Reporter - genetics Genotype Green Fluorescent Proteins - genetics Humans Models, Genetic Mutagenesis - genetics Myotonic Dystrophy - genetics Myotonin-Protein Kinase Physical Chromosome Mapping Plasmids - genetics Protein-Serine-Threonine Kinases - genetics Restriction Mapping Sequence Deletion - genetics Transcription, Genetic - genetics Trinucleotide Repeats - genetics
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