Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice

Several naturally occurring coumarins, to which humans are routinely exposed in the diet, were previously found to inhibit P450-mediated metabolism of benzo[a]pyrene (B[a]P) and 7,12-dimethylbenz[a]anthracene (DMBA) in vitro, block DNA adduct formation in mouse epidermis and inhibit skin tumor initi...

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Veröffentlicht in:	Carcinogenesis (New York) 2001-01, Vol.22 (1), p.73-82
Hauptverfasser:	Kleiner, Heather E., Vulimiri, Suryanarayana V., Miller, Laura, Johnson, William H., Whitman, Christian P., DiGiovanni, John
Format:	Artikel
Sprache:	eng
Schlagworte:	1-chloro-2 12-dimethylbenz[a]anthracene 12-O-tetra- decanoylylphorbol-13-acetate 4-dinitrobenzene 8-methoxypsoralen 8-MOP 9,10-Dimethyl-1,2-benzanthracene - metabolism 9,10-Dimethyl-1,2-benzanthracene - toxicity Administration, Oral Animals Anticarcinogenic Agents - pharmacology antioxidant response element ARE B[a]P Benzo(a)pyrene - antagonists & inhibitors Benzo(a)pyrene - metabolism Benzo(a)pyrene - toxicity benzo[a]pyrene Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - metabolism Carcinogens - toxicity CDNB Chemical agents Cytochrome P-450 CYP1A1 - antagonists & inhibitors Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP2B1 - antagonists & inhibitors Cytochrome P-450 CYP2B1 - metabolism Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism DAS diallyl sulfide DMBA DNA Adducts - antagonists & inhibitors DNA Adducts - biosynthesis EROD ethoxyresorufin O-dealkylase Female Furocoumarins - pharmacology Glutathione Transferase - metabolism glutatione S-transferase GPEI GST GST P enhancer I Liver - drug effects Liver - enzymology Lung - drug effects Lung - enzymology Mammary Glands, Animal - drug effects Mammary Glands, Animal - enzymology Medical sciences Mice Mice, Inbred SENCAR PAH PEITC pentoxyresorufin O-dealkylase phenethyl isothiocyanate phenobarbital polycyclic aromatic hydrocarbon PROD Skin - drug effects Skin - enzymology Stomach - drug effects Stomach - enzymology TPA Tumors xenobiotic-responsive element XRE
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