Micronucleus testing as a cancer detector: endometrial hyperplasia to carcinoma

Purpose Endometrium carcinoma (EC) is the fourth common cancer among women worldwide and the incidence is increasing. It is important to define the EC earlier for survival of the patients. Methods Women who had endometrial hyperplasia (EH) and EC in postmenopausal and premenopausal period were included to participate in this study. MN assay has been performed to participants for detection of the genetic damages and DNA instability. Results MN ratio was significantly higher in EC group compared to other two groups (EH and control groups) ( p 0.05). MN frequency and NDI were significantly correlated with the age in endometrial hyperplasia without atypia, endometrial cancer and control groups ( r 0.546, p