Culture Filtrate of Cryptococcus neoformans var. gattii (CneF) as a Novel Anti‐Inflammatory Compound in the Treatment of Experimental Septic Arthritis
We examined the efficacy of the culture filtrate of Cryptococcus neoformansvar. gattii (CneF) as a novel anti‐inflammatory compound in experimental septic arthritis. Haematogenously infectious arthritis was induced in rats by a single intravenous injection of 109 CFU Staphylococcus aureus producing...
Gespeichert in:
| Veröffentlicht in: | Scandinavian journal of immunology 2000-09, Vol.52 (3), p.278-284 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 284 |
|---|---|
| container_issue | 3 |
| container_start_page | 278 |
| container_title | Scandinavian journal of immunology |
| container_volume | 52 |
| creator | Mirshafiey, A Chitsaz, M Attar, M Mehrabian, F Razavi, A R |
| description | We examined the efficacy of the culture filtrate of Cryptococcus neoformansvar. gattii (CneF) as a novel anti‐inflammatory compound in experimental septic arthritis. Haematogenously infectious arthritis was induced in rats by a single intravenous injection of 109 CFU Staphylococcus aureus producing toxic shock syndrome toxin‐1. CneF solution at two different doses (36 and 72 mg/kg, based on carbohydrate concentration) was administered intraperitoneally 2 h before bacterial inoculation in the prevention groups and simultaneously with the appearance of clinical signs in the therapeutic groups. CneF administration was continued at regular 48‐h intervals for 10 injections. The results of clinical evaluation showed that CneF‐treated rats were significantly protected from disease development compared with nontreated controls. This finding correlated with the results of histological and radiological assessments of the involved joints. Synovial hypertrophy, inflammatory cell infiltration, pannus formation and cartilage/bone destruction were found to be significantly decreased in the prevention and therapeutic groups compared with arthritic controls. The data suggest that CneF may have therapeutic potential in the treatment of septic arthritis. |
| doi_str_mv | 10.1046/j.1365-3083.2000.00779.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17811345</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17811345</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4729-aa68f9042b491835e594206adc22b6d889dbaed70f01c97c6fd7d8947d67fb593</originalsourceid><addsrcrecordid>eNqNkcGO1CAYx4nRuOPoKxjiwayHVihtgcTLpNnRMRs97HomlFKXCS0V6Dpz8xH2uM_nk0idjTGePAHh930ff34AQIxyjMr67T7HpK4yghjJC4RQjhClPD88Aqs_F4_BChGEMl7S6gw8C2GPECYFJU_BGUacFhyVK3DfzDbOXsOtsdHLqKHrYeOPU3TKKTUHOGrXOz_IMcBb6XP4VcZoDDxvRr19A2WAEn5yt9rCzRjNzx93u7G3chhkdP4IGzdMbh47aEYYbzS89lrGQY9xGXNxmLQ3y0laeKWnaBTc-HjjTTThOXjSSxv0i4d1Db5sL66bD9nl5_e7ZnOZqTJFyKSsWZ-SFG3JMSOVrnhZoFp2qijaumOMd63UHUU9wopTVfcd7Vj6k66mfVtxsgavT30n777NOkQxmKC0tTIFn4PAlGFMyiqBr_4B9272Y3qbwJzhgpHErQE7Qcq7ELzuxZQSSn8UGIlFndiLxZBYDIlFnfitThxS6cuH_nM76O6vwpOrBLw7Ad-N1cf_biyuPu7ShvwCie6p0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198128311</pqid></control><display><type>article</type><title>Culture Filtrate of Cryptococcus neoformans var. gattii (CneF) as a Novel Anti‐Inflammatory Compound in the Treatment of Experimental Septic Arthritis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library All Journals</source><creator>Mirshafiey, A ; Chitsaz, M ; Attar, M ; Mehrabian, F ; Razavi, A R</creator><creatorcontrib>Mirshafiey, A ; Chitsaz, M ; Attar, M ; Mehrabian, F ; Razavi, A R</creatorcontrib><description>We examined the efficacy of the culture filtrate of Cryptococcus neoformansvar. gattii (CneF) as a novel anti‐inflammatory compound in experimental septic arthritis. Haematogenously infectious arthritis was induced in rats by a single intravenous injection of 109 CFU Staphylococcus aureus producing toxic shock syndrome toxin‐1. CneF solution at two different doses (36 and 72 mg/kg, based on carbohydrate concentration) was administered intraperitoneally 2 h before bacterial inoculation in the prevention groups and simultaneously with the appearance of clinical signs in the therapeutic groups. CneF administration was continued at regular 48‐h intervals for 10 injections. The results of clinical evaluation showed that CneF‐treated rats were significantly protected from disease development compared with nontreated controls. This finding correlated with the results of histological and radiological assessments of the involved joints. Synovial hypertrophy, inflammatory cell infiltration, pannus formation and cartilage/bone destruction were found to be significantly decreased in the prevention and therapeutic groups compared with arthritic controls. The data suggest that CneF may have therapeutic potential in the treatment of septic arthritis.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1046/j.1365-3083.2000.00779.x</identifier><identifier>PMID: 10972904</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal - toxicity ; Arthritis, Infectious - diagnostic imaging ; Arthritis, Infectious - drug therapy ; Arthritis, Infectious - pathology ; Bacterial Toxins ; Cryptococcus neoformans - chemistry ; Cryptococcus neoformans gattii ; Drug Evaluation, Preclinical ; Enterotoxins ; Female ; Filtration ; Immunosuppressive Agents - therapeutic use ; Immunosuppressive Agents - toxicity ; Mannans - isolation & purification ; Mannans - pharmacology ; Mannans - therapeutic use ; Mycology - methods ; Radiography ; Rats ; Rats, Sprague-Dawley ; Staphylococcal Infections - diagnostic imaging ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - pathology ; Staphylococcus aureus ; Superantigens</subject><ispartof>Scandinavian journal of immunology, 2000-09, Vol.52 (3), p.278-284</ispartof><rights>Copyright Blackwell Scientific Publications Ltd. Sep 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4729-aa68f9042b491835e594206adc22b6d889dbaed70f01c97c6fd7d8947d67fb593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-3083.2000.00779.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-3083.2000.00779.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10972904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mirshafiey, A</creatorcontrib><creatorcontrib>Chitsaz, M</creatorcontrib><creatorcontrib>Attar, M</creatorcontrib><creatorcontrib>Mehrabian, F</creatorcontrib><creatorcontrib>Razavi, A R</creatorcontrib><title>Culture Filtrate of Cryptococcus neoformans var. gattii (CneF) as a Novel Anti‐Inflammatory Compound in the Treatment of Experimental Septic Arthritis</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>We examined the efficacy of the culture filtrate of Cryptococcus neoformansvar. gattii (CneF) as a novel anti‐inflammatory compound in experimental septic arthritis. Haematogenously infectious arthritis was induced in rats by a single intravenous injection of 109 CFU Staphylococcus aureus producing toxic shock syndrome toxin‐1. CneF solution at two different doses (36 and 72 mg/kg, based on carbohydrate concentration) was administered intraperitoneally 2 h before bacterial inoculation in the prevention groups and simultaneously with the appearance of clinical signs in the therapeutic groups. CneF administration was continued at regular 48‐h intervals for 10 injections. The results of clinical evaluation showed that CneF‐treated rats were significantly protected from disease development compared with nontreated controls. This finding correlated with the results of histological and radiological assessments of the involved joints. Synovial hypertrophy, inflammatory cell infiltration, pannus formation and cartilage/bone destruction were found to be significantly decreased in the prevention and therapeutic groups compared with arthritic controls. The data suggest that CneF may have therapeutic potential in the treatment of septic arthritis.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - toxicity</subject><subject>Arthritis, Infectious - diagnostic imaging</subject><subject>Arthritis, Infectious - drug therapy</subject><subject>Arthritis, Infectious - pathology</subject><subject>Bacterial Toxins</subject><subject>Cryptococcus neoformans - chemistry</subject><subject>Cryptococcus neoformans gattii</subject><subject>Drug Evaluation, Preclinical</subject><subject>Enterotoxins</subject><subject>Female</subject><subject>Filtration</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Immunosuppressive Agents - toxicity</subject><subject>Mannans - isolation & purification</subject><subject>Mannans - pharmacology</subject><subject>Mannans - therapeutic use</subject><subject>Mycology - methods</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Staphylococcal Infections - diagnostic imaging</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - pathology</subject><subject>Staphylococcus aureus</subject><subject>Superantigens</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGO1CAYx4nRuOPoKxjiwayHVihtgcTLpNnRMRs97HomlFKXCS0V6Dpz8xH2uM_nk0idjTGePAHh930ff34AQIxyjMr67T7HpK4yghjJC4RQjhClPD88Aqs_F4_BChGEMl7S6gw8C2GPECYFJU_BGUacFhyVK3DfzDbOXsOtsdHLqKHrYeOPU3TKKTUHOGrXOz_IMcBb6XP4VcZoDDxvRr19A2WAEn5yt9rCzRjNzx93u7G3chhkdP4IGzdMbh47aEYYbzS89lrGQY9xGXNxmLQ3y0laeKWnaBTc-HjjTTThOXjSSxv0i4d1Db5sL66bD9nl5_e7ZnOZqTJFyKSsWZ-SFG3JMSOVrnhZoFp2qijaumOMd63UHUU9wopTVfcd7Vj6k66mfVtxsgavT30n777NOkQxmKC0tTIFn4PAlGFMyiqBr_4B9272Y3qbwJzhgpHErQE7Qcq7ELzuxZQSSn8UGIlFndiLxZBYDIlFnfitThxS6cuH_nM76O6vwpOrBLw7Ad-N1cf_biyuPu7ShvwCie6p0A</recordid><startdate>200009</startdate><enddate>200009</enddate><creator>Mirshafiey, A</creator><creator>Chitsaz, M</creator><creator>Attar, M</creator><creator>Mehrabian, F</creator><creator>Razavi, A R</creator><general>Blackwell Science Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>200009</creationdate><title>Culture Filtrate of Cryptococcus neoformans var. gattii (CneF) as a Novel Anti‐Inflammatory Compound in the Treatment of Experimental Septic Arthritis</title><author>Mirshafiey, A ; Chitsaz, M ; Attar, M ; Mehrabian, F ; Razavi, A R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4729-aa68f9042b491835e594206adc22b6d889dbaed70f01c97c6fd7d8947d67fb593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - toxicity</topic><topic>Arthritis, Infectious - diagnostic imaging</topic><topic>Arthritis, Infectious - drug therapy</topic><topic>Arthritis, Infectious - pathology</topic><topic>Bacterial Toxins</topic><topic>Cryptococcus neoformans - chemistry</topic><topic>Cryptococcus neoformans gattii</topic><topic>Drug Evaluation, Preclinical</topic><topic>Enterotoxins</topic><topic>Female</topic><topic>Filtration</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Immunosuppressive Agents - toxicity</topic><topic>Mannans - isolation & purification</topic><topic>Mannans - pharmacology</topic><topic>Mannans - therapeutic use</topic><topic>Mycology - methods</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Staphylococcal Infections - diagnostic imaging</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - pathology</topic><topic>Staphylococcus aureus</topic><topic>Superantigens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mirshafiey, A</creatorcontrib><creatorcontrib>Chitsaz, M</creatorcontrib><creatorcontrib>Attar, M</creatorcontrib><creatorcontrib>Mehrabian, F</creatorcontrib><creatorcontrib>Razavi, A R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mirshafiey, A</au><au>Chitsaz, M</au><au>Attar, M</au><au>Mehrabian, F</au><au>Razavi, A R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Culture Filtrate of Cryptococcus neoformans var. gattii (CneF) as a Novel Anti‐Inflammatory Compound in the Treatment of Experimental Septic Arthritis</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>2000-09</date><risdate>2000</risdate><volume>52</volume><issue>3</issue><spage>278</spage><epage>284</epage><pages>278-284</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>We examined the efficacy of the culture filtrate of Cryptococcus neoformansvar. gattii (CneF) as a novel anti‐inflammatory compound in experimental septic arthritis. Haematogenously infectious arthritis was induced in rats by a single intravenous injection of 109 CFU Staphylococcus aureus producing toxic shock syndrome toxin‐1. CneF solution at two different doses (36 and 72 mg/kg, based on carbohydrate concentration) was administered intraperitoneally 2 h before bacterial inoculation in the prevention groups and simultaneously with the appearance of clinical signs in the therapeutic groups. CneF administration was continued at regular 48‐h intervals for 10 injections. The results of clinical evaluation showed that CneF‐treated rats were significantly protected from disease development compared with nontreated controls. This finding correlated with the results of histological and radiological assessments of the involved joints. Synovial hypertrophy, inflammatory cell infiltration, pannus formation and cartilage/bone destruction were found to be significantly decreased in the prevention and therapeutic groups compared with arthritic controls. The data suggest that CneF may have therapeutic potential in the treatment of septic arthritis.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Science Ltd</pub><pmid>10972904</pmid><doi>10.1046/j.1365-3083.2000.00779.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9475 |
| ispartof | Scandinavian journal of immunology, 2000-09, Vol.52 (3), p.278-284 |
| issn | 0300-9475 1365-3083 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17811345 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals; Wiley Online Library All Journals |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - toxicity Arthritis, Infectious - diagnostic imaging Arthritis, Infectious - drug therapy Arthritis, Infectious - pathology Bacterial Toxins Cryptococcus neoformans - chemistry Cryptococcus neoformans gattii Drug Evaluation, Preclinical Enterotoxins Female Filtration Immunosuppressive Agents - therapeutic use Immunosuppressive Agents - toxicity Mannans - isolation & purification Mannans - pharmacology Mannans - therapeutic use Mycology - methods Radiography Rats Rats, Sprague-Dawley Staphylococcal Infections - diagnostic imaging Staphylococcal Infections - drug therapy Staphylococcal Infections - pathology Staphylococcus aureus Superantigens |
| title | Culture Filtrate of Cryptococcus neoformans var. gattii (CneF) as a Novel Anti‐Inflammatory Compound in the Treatment of Experimental Septic Arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T16%3A19%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Culture%20Filtrate%20of%20Cryptococcus%20neoformans%20var.%20gattii%20(CneF)%20as%20a%20Novel%20Anti%E2%80%90Inflammatory%20Compound%20in%20the%20Treatment%20of%20Experimental%20Septic%20Arthritis&rft.jtitle=Scandinavian%20journal%20of%20immunology&rft.au=Mirshafiey,%20A&rft.date=2000-09&rft.volume=52&rft.issue=3&rft.spage=278&rft.epage=284&rft.pages=278-284&rft.issn=0300-9475&rft.eissn=1365-3083&rft_id=info:doi/10.1046/j.1365-3083.2000.00779.x&rft_dat=%3Cproquest_cross%3E17811345%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=198128311&rft_id=info:pmid/10972904&rfr_iscdi=true |