Manganese Potentiates In Vitro Production of Proinflammatory Cytokines and Nitric Oxide by Microglia Through a Nuclear Factor kappa B–Dependent Mechanism

Recent evidence suggests that the mechanism of manganese (Mn) neurotoxicity involves activation of microglia and/or astrocytes; as a consequence, neurons adjacent to the activated microglia may be injured. Mn modulation of proinflammatory cytokine expression by microglia has not been investigated. T...

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Veröffentlicht in:	Toxicological sciences 2005-03, Vol.84 (1), p.139-148
Hauptverfasser:	Filipov, Nikolay M., Seegal, Richard F., Lawrence, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Buthionine Sulfoximine - pharmacology Cells, Cultured Chromans - pharmacology cytokines Cytokines - biosynthesis Enzyme Inhibitors - pharmacology inflammation Inflammation - metabolism Inflammation - pathology L-Lactate Dehydrogenase - metabolism Lipopolysaccharides - pharmacology manganese Manganese Poisoning - pathology Mice microglia Microglia - drug effects Microglia - metabolism neurotoxicity NF-kappa B - metabolism NG-Nitroarginine Methyl Ester - pharmacology nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Pentoxifylline - pharmacology Phosphodiesterase Inhibitors - pharmacology Serine Proteinase Inhibitors - pharmacology Tosylphenylalanyl Chloromethyl Ketone - pharmacology
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