Didanosine in HIV-1–Infected Patients Experiencing Failure of Antiretroviral Therapy: A Randomized Placebo-Controlled Trial

BackgroundThe antiviral efficacy of didanosine in patients experiencing virological failure is not well known MethodsA total of 168 patients (139 men and 29 women) receiving stable antiretroviral therapy with plasma human immunodeficiency virus type 1 (HIV-1) RNA levels of 1000–100,000 copies/mL wer...

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Veröffentlicht in:	The Journal of infectious diseases 2005-03, Vol.191 (6), p.840-847
Hauptverfasser:	Molina, Jean-Michel, Marcelin, Anne-Geneviève, Pavie, Juliette, Heripret, Laurence, De Boever, Corinne Merle, Troccaz, Martine, Leleu, Ghislaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AIDS Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Antiretrovirals Antivirals Biological and medical sciences Didanosine - adverse effects Didanosine - therapeutic use Double-Blind Method Drug Resistance, Viral - genetics Drug Therapy, Combination Experimentation Female Fundamental and applied biological sciences. Psychology Genetic mutation HIV 1 HIV Infections - drug therapy HIV Infections - virology HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Medical treatment failures Microbiology Middle Aged Mutation Placebos Reverse Transcriptase Inhibitors - adverse effects Reverse Transcriptase Inhibitors - therapeutic use RNA RNA, Viral - blood Statistical median Treatment Failure Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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