Treatment of streptozotocin-induced diabetes mellitus in rats by transplantation of islet cells from two major histocompatibility complex disparate rats in combination with intra bone marrow injection of allogeneic bone marrow cells
We have established a new method for the transplantation of allogeneic pancreatic islets obtained from two different rat strains in combination with a newly developed bone marrow transplantation (BMT) method in which bone marrow cells (BMCs) are directly injected into the bone marrow cavity (intra b...
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| Veröffentlicht in: | Transplantation 2005-03, Vol.79 (6), p.680-687 |
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| container_title | Transplantation |
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| creator | Taira, Mitsuru Inaba, Muneo Takada, Keizo Baba, Susumu Fukui, Junichi Ueda, Yusuke Kwon, A-Hon Hisha, Hiroko Kamiyama, Yasuo Ikehara, Susumu |
| description | We have established a new method for the transplantation of allogeneic pancreatic islets obtained from two different rat strains in combination with a newly developed bone marrow transplantation (BMT) method in which bone marrow cells (BMCs) are directly injected into the bone marrow cavity (intra bone marrow BMT [IBM-BMT]).
Streptozotocin-induced diabetic Brown Norway (BN: RT1A(n)) rats were injected with fludarabine, irradiated with 5.0 Gy x 2, and BMCs from two allogeneic rat strains, Fischer 344 (F344: RT1A(1)) and PVG (PVG: RT1A(c)), were then directly injected into the bone marrow cavity (IBM-BMT). Simultaneously, approximately 600 pancreatic islets (PIs) from F344 and PVG rats were mixed and transplanted into the liver by way of the portal vein.
All the recipients thus treated showed normoglycemia 30 days after the treatment. Hematolymphoid cells were completely reconstituted with the two donor-type cells, and immunologic tolerance to F344 and PVG major histocompatibility complex (MHC) determinants were induced.
The transplantation of PIs from two MHC-disparate donors was completely achieved in combination with IBM-BMT, resulting in the improvement of blood glucose levels and the amelioration of diabetes mellitus. |
| doi_str_mv | 10.1097/01.TP.0000155500.17348.94 |
| format | Article |
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Streptozotocin-induced diabetic Brown Norway (BN: RT1A(n)) rats were injected with fludarabine, irradiated with 5.0 Gy x 2, and BMCs from two allogeneic rat strains, Fischer 344 (F344: RT1A(1)) and PVG (PVG: RT1A(c)), were then directly injected into the bone marrow cavity (IBM-BMT). Simultaneously, approximately 600 pancreatic islets (PIs) from F344 and PVG rats were mixed and transplanted into the liver by way of the portal vein.
All the recipients thus treated showed normoglycemia 30 days after the treatment. Hematolymphoid cells were completely reconstituted with the two donor-type cells, and immunologic tolerance to F344 and PVG major histocompatibility complex (MHC) determinants were induced.
The transplantation of PIs from two MHC-disparate donors was completely achieved in combination with IBM-BMT, resulting in the improvement of blood glucose levels and the amelioration of diabetes mellitus.</description><identifier>ISSN: 0041-1337</identifier><identifier>DOI: 10.1097/01.TP.0000155500.17348.94</identifier><identifier>PMID: 15785374</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Antigens - immunology ; Blood Glucose - metabolism ; Bone Marrow Transplantation - immunology ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - immunology ; Diabetes Mellitus, Experimental - pathology ; Diabetes Mellitus, Experimental - therapy ; Glucose Tolerance Test ; Graft Survival - immunology ; Histocompatibility - immunology ; Islets of Langerhans - pathology ; Islets of Langerhans Transplantation - immunology ; Lymphocyte Culture Test, Mixed ; Rats ; Streptozocin - pharmacology ; Time Factors ; Tissue Donors ; Transplantation Chimera - immunology ; Transplantation, Homologous - immunology</subject><ispartof>Transplantation, 2005-03, Vol.79 (6), p.680-687</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-f58ddc937775f56029b711a7d89586c907fe1ee95dc8c5f6f5df1dcee02cf4463</citedby><cites>FETCH-LOGICAL-c327t-f58ddc937775f56029b711a7d89586c907fe1ee95dc8c5f6f5df1dcee02cf4463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15785374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taira, Mitsuru</creatorcontrib><creatorcontrib>Inaba, Muneo</creatorcontrib><creatorcontrib>Takada, Keizo</creatorcontrib><creatorcontrib>Baba, Susumu</creatorcontrib><creatorcontrib>Fukui, Junichi</creatorcontrib><creatorcontrib>Ueda, Yusuke</creatorcontrib><creatorcontrib>Kwon, A-Hon</creatorcontrib><creatorcontrib>Hisha, Hiroko</creatorcontrib><creatorcontrib>Kamiyama, Yasuo</creatorcontrib><creatorcontrib>Ikehara, Susumu</creatorcontrib><title>Treatment of streptozotocin-induced diabetes mellitus in rats by transplantation of islet cells from two major histocompatibility complex disparate rats in combination with intra bone marrow injection of allogeneic bone marrow cells</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>We have established a new method for the transplantation of allogeneic pancreatic islets obtained from two different rat strains in combination with a newly developed bone marrow transplantation (BMT) method in which bone marrow cells (BMCs) are directly injected into the bone marrow cavity (intra bone marrow BMT [IBM-BMT]).
Streptozotocin-induced diabetic Brown Norway (BN: RT1A(n)) rats were injected with fludarabine, irradiated with 5.0 Gy x 2, and BMCs from two allogeneic rat strains, Fischer 344 (F344: RT1A(1)) and PVG (PVG: RT1A(c)), were then directly injected into the bone marrow cavity (IBM-BMT). Simultaneously, approximately 600 pancreatic islets (PIs) from F344 and PVG rats were mixed and transplanted into the liver by way of the portal vein.
All the recipients thus treated showed normoglycemia 30 days after the treatment. Hematolymphoid cells were completely reconstituted with the two donor-type cells, and immunologic tolerance to F344 and PVG major histocompatibility complex (MHC) determinants were induced.
The transplantation of PIs from two MHC-disparate donors was completely achieved in combination with IBM-BMT, resulting in the improvement of blood glucose levels and the amelioration of diabetes mellitus.</description><subject>Animals</subject><subject>Antigens - immunology</subject><subject>Blood Glucose - metabolism</subject><subject>Bone Marrow Transplantation - immunology</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - immunology</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Glucose Tolerance Test</subject><subject>Graft Survival - immunology</subject><subject>Histocompatibility - immunology</subject><subject>Islets of Langerhans - pathology</subject><subject>Islets of Langerhans Transplantation - immunology</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Rats</subject><subject>Streptozocin - pharmacology</subject><subject>Time Factors</subject><subject>Tissue Donors</subject><subject>Transplantation Chimera - immunology</subject><subject>Transplantation, Homologous - immunology</subject><issn>0041-1337</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1uGyEUhVm0alK3r1DRTXfjgmcww7KK-idFShbuGjFwabBmYAqMXPeJ8xi9jl1FZQNczv3OFYeQ95ytOVPyI-Pr3f2a4eJCCIZV2Xb9WnUvyDVjHW9428or8rqUPWpEK-UrcsWF7PHYXZPHXQZTJ4iVJk9LzTDX9CfVZENsQnSLBUddMANUKHSCcQx1KTREmk0tdDjSmk0s82hiNTWkeMKEMkKlFsWF-pwmWg-JTmafMn0IBdlpmlE8BIQd6ek2wm90KbNBKpzRaIEvQ4hn7CHUB6yhGx1SBMTlnA5Y2YP952vGMf2ECMH-p3ka5A156c1Y4O1lX5EfXz7vbr41t3dfv998um1su5G18aJ3zir8Jim82LKNGiTnRrpeiX5rFZMeOIASzvZW-K0XznNnAdjG-q7btivy4cydc_q1QKl6CuU0gYmQlqK57DE2DGJF1Flocyolg9dzDjjxUXOmT9FqxvXuXj9Hq5-i1arD3ncXk2WYwD13XnJt_wIYCqsr</recordid><startdate>20050327</startdate><enddate>20050327</enddate><creator>Taira, Mitsuru</creator><creator>Inaba, Muneo</creator><creator>Takada, Keizo</creator><creator>Baba, Susumu</creator><creator>Fukui, Junichi</creator><creator>Ueda, Yusuke</creator><creator>Kwon, A-Hon</creator><creator>Hisha, Hiroko</creator><creator>Kamiyama, Yasuo</creator><creator>Ikehara, Susumu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20050327</creationdate><title>Treatment of streptozotocin-induced diabetes mellitus in rats by transplantation of islet cells from two major histocompatibility complex disparate rats in combination with intra bone marrow injection of allogeneic bone marrow cells</title><author>Taira, Mitsuru ; Inaba, Muneo ; Takada, Keizo ; Baba, Susumu ; Fukui, Junichi ; Ueda, Yusuke ; Kwon, A-Hon ; Hisha, Hiroko ; Kamiyama, Yasuo ; Ikehara, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-f58ddc937775f56029b711a7d89586c907fe1ee95dc8c5f6f5df1dcee02cf4463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antigens - immunology</topic><topic>Blood Glucose - metabolism</topic><topic>Bone Marrow Transplantation - immunology</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - immunology</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetes Mellitus, Experimental - therapy</topic><topic>Glucose Tolerance Test</topic><topic>Graft Survival - immunology</topic><topic>Histocompatibility - immunology</topic><topic>Islets of Langerhans - pathology</topic><topic>Islets of Langerhans Transplantation - immunology</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Rats</topic><topic>Streptozocin - pharmacology</topic><topic>Time Factors</topic><topic>Tissue Donors</topic><topic>Transplantation Chimera - immunology</topic><topic>Transplantation, Homologous - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taira, Mitsuru</creatorcontrib><creatorcontrib>Inaba, Muneo</creatorcontrib><creatorcontrib>Takada, Keizo</creatorcontrib><creatorcontrib>Baba, Susumu</creatorcontrib><creatorcontrib>Fukui, Junichi</creatorcontrib><creatorcontrib>Ueda, Yusuke</creatorcontrib><creatorcontrib>Kwon, A-Hon</creatorcontrib><creatorcontrib>Hisha, Hiroko</creatorcontrib><creatorcontrib>Kamiyama, Yasuo</creatorcontrib><creatorcontrib>Ikehara, Susumu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taira, Mitsuru</au><au>Inaba, Muneo</au><au>Takada, Keizo</au><au>Baba, Susumu</au><au>Fukui, Junichi</au><au>Ueda, Yusuke</au><au>Kwon, A-Hon</au><au>Hisha, Hiroko</au><au>Kamiyama, Yasuo</au><au>Ikehara, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of streptozotocin-induced diabetes mellitus in rats by transplantation of islet cells from two major histocompatibility complex disparate rats in combination with intra bone marrow injection of allogeneic bone marrow cells</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2005-03-27</date><risdate>2005</risdate><volume>79</volume><issue>6</issue><spage>680</spage><epage>687</epage><pages>680-687</pages><issn>0041-1337</issn><abstract>We have established a new method for the transplantation of allogeneic pancreatic islets obtained from two different rat strains in combination with a newly developed bone marrow transplantation (BMT) method in which bone marrow cells (BMCs) are directly injected into the bone marrow cavity (intra bone marrow BMT [IBM-BMT]).
Streptozotocin-induced diabetic Brown Norway (BN: RT1A(n)) rats were injected with fludarabine, irradiated with 5.0 Gy x 2, and BMCs from two allogeneic rat strains, Fischer 344 (F344: RT1A(1)) and PVG (PVG: RT1A(c)), were then directly injected into the bone marrow cavity (IBM-BMT). Simultaneously, approximately 600 pancreatic islets (PIs) from F344 and PVG rats were mixed and transplanted into the liver by way of the portal vein.
All the recipients thus treated showed normoglycemia 30 days after the treatment. Hematolymphoid cells were completely reconstituted with the two donor-type cells, and immunologic tolerance to F344 and PVG major histocompatibility complex (MHC) determinants were induced.
The transplantation of PIs from two MHC-disparate donors was completely achieved in combination with IBM-BMT, resulting in the improvement of blood glucose levels and the amelioration of diabetes mellitus.</abstract><cop>United States</cop><pmid>15785374</pmid><doi>10.1097/01.TP.0000155500.17348.94</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transplantation, 2005-03, Vol.79 (6), p.680-687 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Antigens - immunology Blood Glucose - metabolism Bone Marrow Transplantation - immunology Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - therapy Glucose Tolerance Test Graft Survival - immunology Histocompatibility - immunology Islets of Langerhans - pathology Islets of Langerhans Transplantation - immunology Lymphocyte Culture Test, Mixed Rats Streptozocin - pharmacology Time Factors Tissue Donors Transplantation Chimera - immunology Transplantation, Homologous - immunology |
| title | Treatment of streptozotocin-induced diabetes mellitus in rats by transplantation of islet cells from two major histocompatibility complex disparate rats in combination with intra bone marrow injection of allogeneic bone marrow cells |
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