Comparative metabolism and excretion of benzo(a)pyrene in 2 species of ictalurid catfish

Differential susceptibility of polycyclic aromatic hydrocarbon (PAH)-mediated liver cancer exists in two related species of Ictalurid catfish. Two hypotheses are addressed in this study to explain this difference. Specifically, the relatively insensitive channel catfish 1) do not produce mutagenic P...

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Veröffentlicht in:	Toxicological sciences 2000-11, Vol.58 (1), p.68-76
Hauptverfasser:	WILLETT, Kristine L, GARDINALI, Piero R, LIENESCH, Laila A, DI GIULIO, Richard T
Format:	Artikel
Sprache:	eng
Schlagworte:	Agnatha. Pisces Ameiurus nebulosus Animal, plant and microbial ecology Animals Applied ecology Benzo(a)pyrene - metabolism Benzo(a)pyrene - toxicity benzo(a)pyrene-7,8-dihydrodiol Bile - metabolism Biological and medical sciences Carcinogens - metabolism Carcinogens - toxicity Cytochrome P-450 CYP1A1 - metabolism Cytosol - drug effects Cytosol - metabolism Dinitrochlorobenzene - metabolism DNA - drug effects DNA Adducts - drug effects Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Epoxide Hydrolases - metabolism Ethacrynic Acid - metabolism Fundamental and applied biological sciences. Psychology Glutathione Transferase - metabolism Ictaluridae - metabolism Ictalurus Ictalurus punctatus In Vitro Techniques Liver - drug effects Liver - metabolism Microsomes, Liver - drug effects Microsomes, Liver - enzymology Species Specificity
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