CYP1A2 phenotype and genotype in a population from the Carboniferous Region of Coahuila, Mexico

CYP1A2 regulation by polycyclic aromatic hydrocarbons (PAHs) exposure and polymorphism was investigated in 46 male volunteers from the Carboniferous Region in northern Coahuila, Mexico. PAH exposure was estimated by the urinary excretion of 1-hydroxypyrene (1-OHP), whereas the regulatory effects wer...

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Veröffentlicht in:	Toxicology letters 2005-04, Vol.156 (3), p.331-339
Hauptverfasser:	Castorena-Torres, Fabiola, Mendoza-Cantú, Ania, León, Mario Bermúdez de, Cisneros, Bulmaro, Zapata-Pérez, Omar, López-Carrillo, Lizbeth, Salinas, Juan E., Albores, Arnulfo
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Hydroxypyrene Adult Biological and medical sciences Caffeine - metabolism Caffeine - urine Cross-Sectional Studies CYP1A2 polymorphism Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP1A2 - metabolism DNA - chemistry DNA - genetics Environmental Exposure Genotype Humans Linear Models Male Medical sciences Mexico Middle Aged PAH Phenotype Polycyclic Aromatic Hydrocarbons - metabolism Polycyclic Aromatic Hydrocarbons - poisoning Polymerase Chain Reaction Polymorphism, Single Nucleotide Pyrenes - analysis Soil Pollutants - metabolism Soil Pollutants - poisoning Toxicology
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