Mitochondrial ND5 mutations in idiopathic Parkinson’s disease

Idiopathic Parkinson’s disease (PD) is characterized by a systemic loss of activity of complex I (NADH:ubiquinone oxidoreductase), the target enzyme of the parkinsonism producing neurotoxin, MPTP. Cybrid experiments strongly suggest that the loss of complex I activity arises from mitochondrial DNA....

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-01, Vol.326 (3), p.667-669
Hauptverfasser:	Parker, W. Davis, Parks, Janice K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Brain - metabolism Complex I Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Heteroplasmy Humans Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mitochondrial Proteins Mutation Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson’s disease Pathogenesis
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