Pristane-induced autoimmunity in germ-free mice

Hypergammaglobulinemia and autoantibodies are reduced in pristane-treated specific pathogen-free mice vs. conventionally housed controls, consistent with the role of microbial stimulation in this model. To determine whether microbial stimulation is required, BALB/c mice housed under germ-free condit...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2005-02, Vol.114 (2), p.110-118
Hauptverfasser:	Mizutani, Akiei, Shaheen, Victoria M., Yoshida, Hideo, Akaogi, Jun, Kuroda, Yoshiki, Nacionales, Dina C., Yamasaki, Yoshioki, Hirakata, Michito, Ono, Nobutaka, Reeves, Westley H., Satoh, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies Autoantibodies - immunology Biological and medical sciences Body Weight Cytokines Cytokines - blood Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Fundamental immunology Granuloma - immunology Histocytochemistry Hypergammaglobulinemia - immunology Immunopathology Inflammation Liver - immunology Liver - pathology Lupus Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - microbiology Lupus Erythematosus, Systemic - pathology Medical sciences Mice Mice, Inbred BALB C Microbial environment Organ Size Pristane Specific Pathogen-Free Organisms Spleen - immunology Spleen - pathology Statistics, Nonparametric Terpenes - immunology Terpenes - pharmacology
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