Cytotoxic Mechanism of XK469: Resistance of Topoisomerase IIβ Knockout Cells and Inhibition of Topoisomerase I

Topoisomerase IIβ knockout mouse cells (β−/−) were found to have only slight resistance to m-AMSA, a dual topoisomerase IIα-IIβ poison, as compared to wild-type cells (β+/+) during 1 h or 3 day exposures to the drug. In contrast, the β−/− cells were greater than threefold resistant to XK469, a selec...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-02, Vol.280 (4), p.1155-1160
Hauptverfasser:	Snapka, Robert M., Gao, Hanlin, Grabowski, Dale R., Brill, David, Chan, Kenneth K., Li, Ligeng, Li, Gloria C., Ganapathi, Ram
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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