MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies
Owing to its aggressiveness, late detection and marginal therapeutic accessibility, pancreatic ductal adenocarcinoma (PDAC) remains a most challenging malignant disease. Despite scientific progress in the understanding of the mechanisms that underly PDAC initiation and progression, the successful tr...
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| Veröffentlicht in: | Oncogene 2016-03, Vol.35 (13), p.1609-1618 |
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| creator | Hessmann, E Schneider, G Ellenrieder, V Siveke, J T |
| description | Owing to its aggressiveness, late detection and marginal therapeutic accessibility, pancreatic ductal adenocarcinoma (PDAC) remains a most challenging malignant disease. Despite scientific progress in the understanding of the mechanisms that underly PDAC initiation and progression, the successful translation of experimental findings into effective new therapeutic strategies remains a largely unmet need. The oncogene MYC is activated in many PDAC cases and is a master regulator of vital cellular processes. Excellent recent studies have shed new light on the tremendous functions of MYC in cancer and identified inhibition of MYC as a likewise beneficial and demanding effort. This review will focus on mechanisms that contribute to deregulation of MYC expression in pancreatic carcinogenesis and progression and will summarize novel biological findings from recent
in vivo
models. Finally, we provide a perspective, how regulation of MYC in PDAC may contribute to the development of new therapeutic approaches. |
| doi_str_mv | 10.1038/onc.2015.216 |
| format | Article |
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in vivo
models. Finally, we provide a perspective, how regulation of MYC in PDAC may contribute to the development of new therapeutic approaches.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/onc.2015.216</identifier><identifier>PMID: 26119937</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/395 ; 64/110 ; Adenocarcinoma ; Animals ; Apoptosis ; Carcinogenesis ; Carcinoma, Pancreatic Ductal - genetics ; Carcinoma, Pancreatic Ductal - pathology ; Carcinoma, Pancreatic Ductal - therapy ; Cell Biology ; Cell Transformation, Neoplastic - genetics ; Development and progression ; Disease Progression ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genes, myc - physiology ; Genetic aspects ; Health aspects ; Human Genetics ; Humans ; Innovations ; Internal Medicine ; Medicine ; Medicine & Public Health ; Molecular targeted therapy ; Molecular Targeted Therapy - methods ; Molecular Targeted Therapy - trends ; Myc protein ; Oncology ; Pancreatic cancer ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - therapy ; Protein expression ; review ; Signal transduction ; Transcription, Genetic ; Translation ; Tumorigenesis</subject><ispartof>Oncogene, 2016-03, Vol.35 (13), p.1609-1618</ispartof><rights>Macmillan Publishers Limited 2016</rights><rights>COPYRIGHT 2016 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 31, 2016</rights><rights>Macmillan Publishers Limited 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-9a1d927cda6a2927b0e99efe435154220810b1bba01410c715d932cccce475053</citedby><cites>FETCH-LOGICAL-c523t-9a1d927cda6a2927b0e99efe435154220810b1bba01410c715d932cccce475053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26119937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hessmann, E</creatorcontrib><creatorcontrib>Schneider, G</creatorcontrib><creatorcontrib>Ellenrieder, V</creatorcontrib><creatorcontrib>Siveke, J T</creatorcontrib><title>MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Owing to its aggressiveness, late detection and marginal therapeutic accessibility, pancreatic ductal adenocarcinoma (PDAC) remains a most challenging malignant disease. Despite scientific progress in the understanding of the mechanisms that underly PDAC initiation and progression, the successful translation of experimental findings into effective new therapeutic strategies remains a largely unmet need. The oncogene MYC is activated in many PDAC cases and is a master regulator of vital cellular processes. Excellent recent studies have shed new light on the tremendous functions of MYC in cancer and identified inhibition of MYC as a likewise beneficial and demanding effort. This review will focus on mechanisms that contribute to deregulation of MYC expression in pancreatic carcinogenesis and progression and will summarize novel biological findings from recent
in vivo
models. Finally, we provide a perspective, how regulation of MYC in PDAC may contribute to the development of new therapeutic approaches.</description><subject>631/67/395</subject><subject>64/110</subject><subject>Adenocarcinoma</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Carcinogenesis</subject><subject>Carcinoma, Pancreatic Ductal - genetics</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Carcinoma, Pancreatic Ductal - therapy</subject><subject>Cell Biology</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes, myc - physiology</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Innovations</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Molecular targeted therapy</subject><subject>Molecular Targeted Therapy - methods</subject><subject>Molecular Targeted Therapy - trends</subject><subject>Myc protein</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - therapy</subject><subject>Protein expression</subject><subject>review</subject><subject>Signal transduction</subject><subject>Transcription, 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Neoplastic</topic><topic>Genes, myc - physiology</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Innovations</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Molecular targeted therapy</topic><topic>Molecular Targeted Therapy - methods</topic><topic>Molecular Targeted Therapy - trends</topic><topic>Myc protein</topic><topic>Oncology</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - therapy</topic><topic>Protein expression</topic><topic>review</topic><topic>Signal transduction</topic><topic>Transcription, Genetic</topic><topic>Translation</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hessmann, E</creatorcontrib><creatorcontrib>Schneider, 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Despite scientific progress in the understanding of the mechanisms that underly PDAC initiation and progression, the successful translation of experimental findings into effective new therapeutic strategies remains a largely unmet need. The oncogene MYC is activated in many PDAC cases and is a master regulator of vital cellular processes. Excellent recent studies have shed new light on the tremendous functions of MYC in cancer and identified inhibition of MYC as a likewise beneficial and demanding effort. This review will focus on mechanisms that contribute to deregulation of MYC expression in pancreatic carcinogenesis and progression and will summarize novel biological findings from recent
in vivo
models. Finally, we provide a perspective, how regulation of MYC in PDAC may contribute to the development of new therapeutic approaches.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26119937</pmid><doi>10.1038/onc.2015.216</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/67/395 64/110 Adenocarcinoma Animals Apoptosis Carcinogenesis Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Cell Biology Cell Transformation, Neoplastic - genetics Development and progression Disease Progression Gene expression Gene Expression Regulation, Neoplastic Genes, myc - physiology Genetic aspects Health aspects Human Genetics Humans Innovations Internal Medicine Medicine Medicine & Public Health Molecular targeted therapy Molecular Targeted Therapy - methods Molecular Targeted Therapy - trends Myc protein Oncology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Protein expression review Signal transduction Transcription, Genetic Translation Tumorigenesis |
| title | MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies |
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