The anti-inflammatory effects of baicalin through suppression of NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

In this study, the anti-inflammatory effects and mechanisms of baicalin on LPS-induced NLRP3 inflammatory pathway were investigated in piglet mononuclear phagocytes (control, LPS stimulation, LPS stimulation + 12.5 µg/ml baicalin, LPS stimulation + 25 µg/ml baicalin, LPS stimulation + 50 µg/ml baica...

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Veröffentlicht in:	Innate immunity (London, England) England), 2016-04, Vol.22 (3), p.196-204
Hauptverfasser:	Ye, Chun, Li, Sali, Yao, Wenxu, Xu, Lei, Qiu, Yinsheng, Liu, Yu, Wu, Zhongyuan, Hou, Yongqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Caspase 1 - metabolism Cells, Cultured Flavonoids - pharmacology Gene Expression Regulation - drug effects Inflammasomes - drug effects Inflammasomes - physiology Inflammation - drug therapy Inflammation - immunology Interleukin-18 - metabolism Interleukin-1beta - metabolism Lipopolysaccharides - immunology Mononuclear Phagocyte System - drug effects NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Phagocytes - drug effects Phagocytes - immunology Phagocytosis - drug effects Reactive Oxygen Species - metabolism Swine Tumor Necrosis Factor-alpha - metabolism
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