Association Between Chronic Aspiration and Chronic Airway Infection with Pseudomonas aeruginosa and Other Gram-Negative Bacteria in Children with Cerebral Palsy
Purpose Children with cerebral palsy (CP) are at an increased risk for aspiration, and subsequent pneumonia or pneumonitis. Pneumonia is a common cause of hospital admission, intensive care unit (ICU) admission, and death in patients with CP, and may disproportionately contribute to mortality. The r...
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creator | Gerdung, Christopher A. Tsang, Adrian Yasseen, Abdool S. Armstrong, Kathleen McMillan, Hugh J. Kovesi, Thomas |
description | Purpose
Children with cerebral palsy (CP) are at an increased risk for aspiration, and subsequent pneumonia or pneumonitis. Pneumonia is a common cause of hospital admission, intensive care unit (ICU) admission, and death in patients with CP, and may disproportionately contribute to mortality. The role of respiratory microflora is unknown. This study examined the relationship between respiratory infections with Gram-negative bacteria (GNB), particularly
Pseudomonas aeruginosa
, and the frequency/severity of pneumonia hospitalization.
Methods
Retrospective chart review of 69 patients with CP and hospitalization for pneumonia. Eligible patients required hospitalization for bacterial pneumonia, at least one respiratory culture, and fulfillment of Bax definition of CP. Group assignment was based on respiratory culture. Charts were analyzed for comorbid illness, hospitalization demographics, and disease severity.
Results
Children with isolation of
P. aeruginosa
or other GNB had increased frequency of ICU admission (77.4, 65.1, vs. 26.9 %, respectively,
p
< 0.01), intubation (45.2, 39.5 vs. 11.5 %,
p
= 0.02,
p
= 0.03 respectively), and large pleural effusions (37.5, vs. 0 %) than children without GNB. Children with isolation of GNB had more prolonged hospitalizations and were more likely to have multiple hospitalizations than those without GNB.
Conclusion
Colonization with
P. aeruginosa
and other Gram-negative organisms in children with CP is associated with increased morbidity, prolonged hospitalization, and severity of pneumonia including need for PICU admission and intervention. Further research is required to determine causality, the role of antimicrobials active against Gram negative in pneumonia treatment, and the role of GNB eradication therapy in children with CP. |
doi_str_mv | 10.1007/s00408-016-9856-5 |
format | Article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1780527289</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A446755792</galeid><sourcerecordid>A446755792</sourcerecordid><originalsourceid>FETCH-LOGICAL-c611t-3032980c41952ba653355cc328cdc0b22b8e2e9c3e7ace1de8c5fea057b79a8c3</originalsourceid><addsrcrecordid>eNqNks1u1DAUhSMEokPhAdigSEiITYp_4thZTkdQKlW0C1hbjnOTcZXYg510NG_Do-JMBpiiQUJeXMn3O-fK1ydJXmN0gRHiHwJCORIZwkVWClZk7EmywDklGeYMPU0WiOY4I5E5S16EcI8Q5gVmz5MzUghBMc0XyY9lCE4bNRhn00sYtgA2Xa29s0any7Axfm4pW_-5Nn6rdum1bUDvm1szrNO7AGPtemdVSBX4sTXWBbUX3g5r8OmVV332Bdpo-ADppdIDeKNSM80zXe3hYLQCD5VXXXqnurB7mTxrYoVXh3qefPv08evqc3Zze3W9Wt5kusB4yCiipBRI57hkpFIFo5QxrSkRutaoIqQSQKDUFLjSgGsQmjWgEOMVL5XQ9Dx5P_tuvPs-Qhhkb4KGrlMW3Bgk5gIxwoko_wPleZwflxzRt3-h9270Nj5kT5GS42OqVR1IYxs3eKUnU7nM84IzxksSqewE1YKFuCxnoTHx-hF_cYKPp4be6JOCd0eCNahuWAfXjdMfh8cgnkHtXQgeGrnxpld-JzGSUzLlnEwZkymnZEoWNW8OmxirHurfil9RjACZgRBbtgV_tKp_uv4E_87s5w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1774297168</pqid></control><display><type>article</type><title>Association Between Chronic Aspiration and Chronic Airway Infection with Pseudomonas aeruginosa and Other Gram-Negative Bacteria in Children with Cerebral Palsy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Gerdung, Christopher A. ; Tsang, Adrian ; Yasseen, Abdool S. ; Armstrong, Kathleen ; McMillan, Hugh J. ; Kovesi, Thomas</creator><creatorcontrib>Gerdung, Christopher A. ; Tsang, Adrian ; Yasseen, Abdool S. ; Armstrong, Kathleen ; McMillan, Hugh J. ; Kovesi, Thomas</creatorcontrib><description>Purpose
Children with cerebral palsy (CP) are at an increased risk for aspiration, and subsequent pneumonia or pneumonitis. Pneumonia is a common cause of hospital admission, intensive care unit (ICU) admission, and death in patients with CP, and may disproportionately contribute to mortality. The role of respiratory microflora is unknown. This study examined the relationship between respiratory infections with Gram-negative bacteria (GNB), particularly
Pseudomonas aeruginosa
, and the frequency/severity of pneumonia hospitalization.
Methods
Retrospective chart review of 69 patients with CP and hospitalization for pneumonia. Eligible patients required hospitalization for bacterial pneumonia, at least one respiratory culture, and fulfillment of Bax definition of CP. Group assignment was based on respiratory culture. Charts were analyzed for comorbid illness, hospitalization demographics, and disease severity.
Results
Children with isolation of
P. aeruginosa
or other GNB had increased frequency of ICU admission (77.4, 65.1, vs. 26.9 %, respectively,
p
< 0.01), intubation (45.2, 39.5 vs. 11.5 %,
p
= 0.02,
p
= 0.03 respectively), and large pleural effusions (37.5, vs. 0 %) than children without GNB. Children with isolation of GNB had more prolonged hospitalizations and were more likely to have multiple hospitalizations than those without GNB.
Conclusion
Colonization with
P. aeruginosa
and other Gram-negative organisms in children with CP is associated with increased morbidity, prolonged hospitalization, and severity of pneumonia including need for PICU admission and intervention. Further research is required to determine causality, the role of antimicrobials active against Gram negative in pneumonia treatment, and the role of GNB eradication therapy in children with CP.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-016-9856-5</identifier><identifier>PMID: 26883134</identifier><identifier>CODEN: LUNGD9</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Age Factors ; Bacteria ; Brain injuries ; Care and treatment ; Cerebral palsy ; Cerebral Palsy - complications ; Cerebral Palsy - diagnosis ; Child ; Comorbidity ; Complications and side effects ; Female ; Gram-negative bacteria ; Hospitalization ; Humans ; Infections ; Length of Stay ; Male ; Medicine ; Medicine & Public Health ; Patient Admission ; Pediatrics ; Physiological aspects ; Pneumology/Respiratory System ; Pneumonia ; Pneumonia, Aspiration - diagnosis ; Pneumonia, Aspiration - microbiology ; Pneumonia, Aspiration - therapy ; Pneumonia, Bacterial - diagnosis ; Pneumonia, Bacterial - microbiology ; Pneumonia, Bacterial - therapy ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - isolation & purification ; Pseudomonas Infections - diagnosis ; Pseudomonas Infections - microbiology ; Pseudomonas Infections - therapy ; Respiratory Aspiration of Gastric Contents - diagnosis ; Respiratory Aspiration of Gastric Contents - etiology ; Respiratory Aspiration of Gastric Contents - therapy ; Retrospective Studies ; Risk Factors ; Severity of Illness Index</subject><ispartof>Lung, 2016-04, Vol.194 (2), p.307-314</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-3032980c41952ba653355cc328cdc0b22b8e2e9c3e7ace1de8c5fea057b79a8c3</citedby><cites>FETCH-LOGICAL-c611t-3032980c41952ba653355cc328cdc0b22b8e2e9c3e7ace1de8c5fea057b79a8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00408-016-9856-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00408-016-9856-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26883134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerdung, Christopher A.</creatorcontrib><creatorcontrib>Tsang, Adrian</creatorcontrib><creatorcontrib>Yasseen, Abdool S.</creatorcontrib><creatorcontrib>Armstrong, Kathleen</creatorcontrib><creatorcontrib>McMillan, Hugh J.</creatorcontrib><creatorcontrib>Kovesi, Thomas</creatorcontrib><title>Association Between Chronic Aspiration and Chronic Airway Infection with Pseudomonas aeruginosa and Other Gram-Negative Bacteria in Children with Cerebral Palsy</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Purpose
Children with cerebral palsy (CP) are at an increased risk for aspiration, and subsequent pneumonia or pneumonitis. Pneumonia is a common cause of hospital admission, intensive care unit (ICU) admission, and death in patients with CP, and may disproportionately contribute to mortality. The role of respiratory microflora is unknown. This study examined the relationship between respiratory infections with Gram-negative bacteria (GNB), particularly
Pseudomonas aeruginosa
, and the frequency/severity of pneumonia hospitalization.
Methods
Retrospective chart review of 69 patients with CP and hospitalization for pneumonia. Eligible patients required hospitalization for bacterial pneumonia, at least one respiratory culture, and fulfillment of Bax definition of CP. Group assignment was based on respiratory culture. Charts were analyzed for comorbid illness, hospitalization demographics, and disease severity.
Results
Children with isolation of
P. aeruginosa
or other GNB had increased frequency of ICU admission (77.4, 65.1, vs. 26.9 %, respectively,
p
< 0.01), intubation (45.2, 39.5 vs. 11.5 %,
p
= 0.02,
p
= 0.03 respectively), and large pleural effusions (37.5, vs. 0 %) than children without GNB. Children with isolation of GNB had more prolonged hospitalizations and were more likely to have multiple hospitalizations than those without GNB.
Conclusion
Colonization with
P. aeruginosa
and other Gram-negative organisms in children with CP is associated with increased morbidity, prolonged hospitalization, and severity of pneumonia including need for PICU admission and intervention. Further research is required to determine causality, the role of antimicrobials active against Gram negative in pneumonia treatment, and the role of GNB eradication therapy in children with CP.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Bacteria</subject><subject>Brain injuries</subject><subject>Care and treatment</subject><subject>Cerebral palsy</subject><subject>Cerebral Palsy - complications</subject><subject>Cerebral Palsy - diagnosis</subject><subject>Child</subject><subject>Comorbidity</subject><subject>Complications and side effects</subject><subject>Female</subject><subject>Gram-negative bacteria</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infections</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Patient Admission</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>Pneumology/Respiratory System</subject><subject>Pneumonia</subject><subject>Pneumonia, Aspiration - diagnosis</subject><subject>Pneumonia, Aspiration - microbiology</subject><subject>Pneumonia, Aspiration - therapy</subject><subject>Pneumonia, Bacterial - diagnosis</subject><subject>Pneumonia, Bacterial - microbiology</subject><subject>Pneumonia, Bacterial - therapy</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Pseudomonas Infections - diagnosis</subject><subject>Pseudomonas Infections - microbiology</subject><subject>Pseudomonas Infections - therapy</subject><subject>Respiratory Aspiration of Gastric Contents - diagnosis</subject><subject>Respiratory Aspiration of Gastric Contents - etiology</subject><subject>Respiratory Aspiration of Gastric Contents - therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks1u1DAUhSMEokPhAdigSEiITYp_4thZTkdQKlW0C1hbjnOTcZXYg510NG_Do-JMBpiiQUJeXMn3O-fK1ydJXmN0gRHiHwJCORIZwkVWClZk7EmywDklGeYMPU0WiOY4I5E5S16EcI8Q5gVmz5MzUghBMc0XyY9lCE4bNRhn00sYtgA2Xa29s0any7Axfm4pW_-5Nn6rdum1bUDvm1szrNO7AGPtemdVSBX4sTXWBbUX3g5r8OmVV332Bdpo-ADppdIDeKNSM80zXe3hYLQCD5VXXXqnurB7mTxrYoVXh3qefPv08evqc3Zze3W9Wt5kusB4yCiipBRI57hkpFIFo5QxrSkRutaoIqQSQKDUFLjSgGsQmjWgEOMVL5XQ9Dx5P_tuvPs-Qhhkb4KGrlMW3Bgk5gIxwoko_wPleZwflxzRt3-h9270Nj5kT5GS42OqVR1IYxs3eKUnU7nM84IzxksSqewE1YKFuCxnoTHx-hF_cYKPp4be6JOCd0eCNahuWAfXjdMfh8cgnkHtXQgeGrnxpld-JzGSUzLlnEwZkymnZEoWNW8OmxirHurfil9RjACZgRBbtgV_tKp_uv4E_87s5w</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Gerdung, Christopher A.</creator><creator>Tsang, Adrian</creator><creator>Yasseen, Abdool S.</creator><creator>Armstrong, Kathleen</creator><creator>McMillan, Hugh J.</creator><creator>Kovesi, Thomas</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Association Between Chronic Aspiration and Chronic Airway Infection with Pseudomonas aeruginosa and Other Gram-Negative Bacteria in Children with Cerebral Palsy</title><author>Gerdung, Christopher A. ; Tsang, Adrian ; Yasseen, Abdool S. ; Armstrong, Kathleen ; McMillan, Hugh J. ; Kovesi, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-3032980c41952ba653355cc328cdc0b22b8e2e9c3e7ace1de8c5fea057b79a8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Bacteria</topic><topic>Brain injuries</topic><topic>Care and treatment</topic><topic>Cerebral palsy</topic><topic>Cerebral Palsy - complications</topic><topic>Cerebral Palsy - diagnosis</topic><topic>Child</topic><topic>Comorbidity</topic><topic>Complications and side effects</topic><topic>Female</topic><topic>Gram-negative bacteria</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infections</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Patient Admission</topic><topic>Pediatrics</topic><topic>Physiological aspects</topic><topic>Pneumology/Respiratory System</topic><topic>Pneumonia</topic><topic>Pneumonia, Aspiration - diagnosis</topic><topic>Pneumonia, Aspiration - microbiology</topic><topic>Pneumonia, Aspiration - therapy</topic><topic>Pneumonia, Bacterial - diagnosis</topic><topic>Pneumonia, Bacterial - microbiology</topic><topic>Pneumonia, Bacterial - therapy</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - isolation & purification</topic><topic>Pseudomonas Infections - diagnosis</topic><topic>Pseudomonas Infections - microbiology</topic><topic>Pseudomonas Infections - therapy</topic><topic>Respiratory Aspiration of Gastric Contents - diagnosis</topic><topic>Respiratory Aspiration of Gastric Contents - etiology</topic><topic>Respiratory Aspiration of Gastric Contents - therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerdung, Christopher A.</creatorcontrib><creatorcontrib>Tsang, Adrian</creatorcontrib><creatorcontrib>Yasseen, Abdool S.</creatorcontrib><creatorcontrib>Armstrong, Kathleen</creatorcontrib><creatorcontrib>McMillan, Hugh J.</creatorcontrib><creatorcontrib>Kovesi, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerdung, Christopher A.</au><au>Tsang, Adrian</au><au>Yasseen, Abdool S.</au><au>Armstrong, Kathleen</au><au>McMillan, Hugh J.</au><au>Kovesi, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Chronic Aspiration and Chronic Airway Infection with Pseudomonas aeruginosa and Other Gram-Negative Bacteria in Children with Cerebral Palsy</atitle><jtitle>Lung</jtitle><stitle>Lung</stitle><addtitle>Lung</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>194</volume><issue>2</issue><spage>307</spage><epage>314</epage><pages>307-314</pages><issn>0341-2040</issn><eissn>1432-1750</eissn><coden>LUNGD9</coden><abstract>Purpose
Children with cerebral palsy (CP) are at an increased risk for aspiration, and subsequent pneumonia or pneumonitis. Pneumonia is a common cause of hospital admission, intensive care unit (ICU) admission, and death in patients with CP, and may disproportionately contribute to mortality. The role of respiratory microflora is unknown. This study examined the relationship between respiratory infections with Gram-negative bacteria (GNB), particularly
Pseudomonas aeruginosa
, and the frequency/severity of pneumonia hospitalization.
Methods
Retrospective chart review of 69 patients with CP and hospitalization for pneumonia. Eligible patients required hospitalization for bacterial pneumonia, at least one respiratory culture, and fulfillment of Bax definition of CP. Group assignment was based on respiratory culture. Charts were analyzed for comorbid illness, hospitalization demographics, and disease severity.
Results
Children with isolation of
P. aeruginosa
or other GNB had increased frequency of ICU admission (77.4, 65.1, vs. 26.9 %, respectively,
p
< 0.01), intubation (45.2, 39.5 vs. 11.5 %,
p
= 0.02,
p
= 0.03 respectively), and large pleural effusions (37.5, vs. 0 %) than children without GNB. Children with isolation of GNB had more prolonged hospitalizations and were more likely to have multiple hospitalizations than those without GNB.
Conclusion
Colonization with
P. aeruginosa
and other Gram-negative organisms in children with CP is associated with increased morbidity, prolonged hospitalization, and severity of pneumonia including need for PICU admission and intervention. Further research is required to determine causality, the role of antimicrobials active against Gram negative in pneumonia treatment, and the role of GNB eradication therapy in children with CP.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26883134</pmid><doi>10.1007/s00408-016-9856-5</doi><tpages>8</tpages></addata></record> |
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subjects | Adolescent Age Factors Bacteria Brain injuries Care and treatment Cerebral palsy Cerebral Palsy - complications Cerebral Palsy - diagnosis Child Comorbidity Complications and side effects Female Gram-negative bacteria Hospitalization Humans Infections Length of Stay Male Medicine Medicine & Public Health Patient Admission Pediatrics Physiological aspects Pneumology/Respiratory System Pneumonia Pneumonia, Aspiration - diagnosis Pneumonia, Aspiration - microbiology Pneumonia, Aspiration - therapy Pneumonia, Bacterial - diagnosis Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - therapy Pseudomonas aeruginosa Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - diagnosis Pseudomonas Infections - microbiology Pseudomonas Infections - therapy Respiratory Aspiration of Gastric Contents - diagnosis Respiratory Aspiration of Gastric Contents - etiology Respiratory Aspiration of Gastric Contents - therapy Retrospective Studies Risk Factors Severity of Illness Index |
title | Association Between Chronic Aspiration and Chronic Airway Infection with Pseudomonas aeruginosa and Other Gram-Negative Bacteria in Children with Cerebral Palsy |
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