Perfusion scintigraphy versus 256-slice CT angiography in pregnant patients suspected of pulmonary embolism: comparison of radiation risks
One aim of the current study was to determine normalized dose data for maternal radiosensitive organs and embryo/fetus from 256-slice CT pulmonary angiography (CTPA) performed on pregnant patients suspected of having pulmonary embolism. A second aim was to provide reliable maternal and fetal doses a...
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| Veröffentlicht in: | Journal of Nuclear Medicine 2014-08, Vol.55 (8), p.1273-1280 |
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| creator | Perisinakis, Kostas Seimenis, Ioannis Tzedakis, Antonis Damilakis, John |
| description | One aim of the current study was to determine normalized dose data for maternal radiosensitive organs and embryo/fetus from 256-slice CT pulmonary angiography (CTPA) performed on pregnant patients suspected of having pulmonary embolism. A second aim was to provide reliable maternal and fetal doses and associated radiation cancer risk estimates from 256-slice CTPA and lung perfusion scintigraphy (LPS) for comparison.
Mathematic anthropomorphic phantoms were generated to simulate the average woman at early pregnancy and at the third, sixth, and ninth months of gestation. In each phantom, 0-3 additional 1.5-cm-thick fat tissue layers were added to derive 4 phantoms representing pregnant women with different body sizes. Monte Carlo methods were used to simulate low-dose 256-slice CTPA exposures on each of the 16 generated phantoms. Normalized organ and embryo/fetal dose data were derived for exposures at 80, 100, and 120 kV. Maternal effective dose and embryo/fetal dose from 256-slice CTPA and associated lifetime attributable risks of radiation cancer were determined for different body sizes and gestational stages and compared with corresponding data from LPS.
For an average-sized pregnant patient at the first trimester, the 256-slice CTPA exposure resulted in a maternal effective dose of 1 mSv and an embryo/fetal dose of 0.05 mGy. However, maternal effective dose considerably increased with body size, whereas embryo/fetal dose increased with both body size and gestational stage. Compared with LPS, low-dose CTPA to an average-sized pregnant patient resulted in a 30% higher maternal effective dose but a 3.4-6 times lower embryo/fetal dose. Nevertheless, LPS was associated with less aggregated radiation risk for an average-sized pregnant patient, with the difference from CTPA being increased further for larger patients.
Compared with CTPA performed with a modern wide-area CT scanner, LPS remains comparatively more dose-efficient. |
| doi_str_mv | 10.2967/jnumed.114.137968 |
| format | Article |
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Mathematic anthropomorphic phantoms were generated to simulate the average woman at early pregnancy and at the third, sixth, and ninth months of gestation. In each phantom, 0-3 additional 1.5-cm-thick fat tissue layers were added to derive 4 phantoms representing pregnant women with different body sizes. Monte Carlo methods were used to simulate low-dose 256-slice CTPA exposures on each of the 16 generated phantoms. Normalized organ and embryo/fetal dose data were derived for exposures at 80, 100, and 120 kV. Maternal effective dose and embryo/fetal dose from 256-slice CTPA and associated lifetime attributable risks of radiation cancer were determined for different body sizes and gestational stages and compared with corresponding data from LPS.
For an average-sized pregnant patient at the first trimester, the 256-slice CTPA exposure resulted in a maternal effective dose of 1 mSv and an embryo/fetal dose of 0.05 mGy. However, maternal effective dose considerably increased with body size, whereas embryo/fetal dose increased with both body size and gestational stage. Compared with LPS, low-dose CTPA to an average-sized pregnant patient resulted in a 30% higher maternal effective dose but a 3.4-6 times lower embryo/fetal dose. Nevertheless, LPS was associated with less aggregated radiation risk for an average-sized pregnant patient, with the difference from CTPA being increased further for larger patients.
Compared with CTPA performed with a modern wide-area CT scanner, LPS remains comparatively more dose-efficient.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>EISSN: 2159-662X</identifier><identifier>DOI: 10.2967/jnumed.114.137968</identifier><identifier>PMID: 24876205</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>United States: Society of Nuclear Medicine</publisher><subject>Angiography - adverse effects ; Autoradiography ; Child ; Female ; Fetus - radiation effects ; Humans ; Lung - blood supply ; Lung - diagnostic imaging ; Medical imaging ; Neoplasms, Radiation-Induced - etiology ; Perfusion Imaging - adverse effects ; Pregnancy ; Pregnancy Complications - diagnostic imaging ; Prenatal Exposure Delayed Effects - etiology ; Pulmonary Embolism - diagnostic imaging ; Radiation therapy ; Regional Blood Flow ; Risk Assessment ; Simulation ; Tissues</subject><ispartof>Journal of Nuclear Medicine, 2014-08, Vol.55 (8), p.1273-1280</ispartof><rights>2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.</rights><rights>Copyright Society of Nuclear Medicine Aug 1, 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-b41256d56e97ee9192cdcf4b7f748b98127ff022cdd770b5c4f92075b8477ec13</citedby><cites>FETCH-LOGICAL-c405t-b41256d56e97ee9192cdcf4b7f748b98127ff022cdd770b5c4f92075b8477ec13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24876205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perisinakis, Kostas</creatorcontrib><creatorcontrib>Seimenis, Ioannis</creatorcontrib><creatorcontrib>Tzedakis, Antonis</creatorcontrib><creatorcontrib>Damilakis, John</creatorcontrib><title>Perfusion scintigraphy versus 256-slice CT angiography in pregnant patients suspected of pulmonary embolism: comparison of radiation risks</title><title>Journal of Nuclear Medicine</title><addtitle>J Nucl Med</addtitle><description>One aim of the current study was to determine normalized dose data for maternal radiosensitive organs and embryo/fetus from 256-slice CT pulmonary angiography (CTPA) performed on pregnant patients suspected of having pulmonary embolism. A second aim was to provide reliable maternal and fetal doses and associated radiation cancer risk estimates from 256-slice CTPA and lung perfusion scintigraphy (LPS) for comparison.
Mathematic anthropomorphic phantoms were generated to simulate the average woman at early pregnancy and at the third, sixth, and ninth months of gestation. In each phantom, 0-3 additional 1.5-cm-thick fat tissue layers were added to derive 4 phantoms representing pregnant women with different body sizes. Monte Carlo methods were used to simulate low-dose 256-slice CTPA exposures on each of the 16 generated phantoms. Normalized organ and embryo/fetal dose data were derived for exposures at 80, 100, and 120 kV. Maternal effective dose and embryo/fetal dose from 256-slice CTPA and associated lifetime attributable risks of radiation cancer were determined for different body sizes and gestational stages and compared with corresponding data from LPS.
For an average-sized pregnant patient at the first trimester, the 256-slice CTPA exposure resulted in a maternal effective dose of 1 mSv and an embryo/fetal dose of 0.05 mGy. However, maternal effective dose considerably increased with body size, whereas embryo/fetal dose increased with both body size and gestational stage. Compared with LPS, low-dose CTPA to an average-sized pregnant patient resulted in a 30% higher maternal effective dose but a 3.4-6 times lower embryo/fetal dose. Nevertheless, LPS was associated with less aggregated radiation risk for an average-sized pregnant patient, with the difference from CTPA being increased further for larger patients.
Compared with CTPA performed with a modern wide-area CT scanner, LPS remains comparatively more dose-efficient.</description><subject>Angiography - adverse effects</subject><subject>Autoradiography</subject><subject>Child</subject><subject>Female</subject><subject>Fetus - radiation effects</subject><subject>Humans</subject><subject>Lung - blood supply</subject><subject>Lung - diagnostic imaging</subject><subject>Medical imaging</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Perfusion Imaging - adverse effects</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - diagnostic imaging</subject><subject>Prenatal Exposure Delayed Effects - etiology</subject><subject>Pulmonary Embolism - diagnostic imaging</subject><subject>Radiation therapy</subject><subject>Regional Blood Flow</subject><subject>Risk Assessment</subject><subject>Simulation</subject><subject>Tissues</subject><issn>0161-5505</issn><issn>1535-5667</issn><issn>2159-662X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGOFCEQhonRuOPqA3gxJF720iPQQIE3M3Fdk030sHsm3TSMjN3QQrfJvoJPvUxm9uJlT4Sq7_-h6kfoPSVbpiV8OsR1csOWUr6lLWipXqANFa1ohJTwEm0IlbQRgogL9KaUAyFEKqVeowvGFUhGxAb9--myX0tIERcb4hL2uZt_PeC_Lpe1YCZkU8ZgHd7d4S7uQzr3Q8RzdvvYxQXP3RJcXAquitnZxQ04eTyv45Rilx-wm_o0hjJ9xjZNc5dDqa9VIndDqNJ6qaXf5S165buxuHfn8xLdX3-92900tz--fd99uW0sJ2Jpek7rrwYhnQbnNNXMDtbzHjxw1WtFGXhPWK0OAKQXlnvNCIhecQBnaXuJrk6-c05_VlcWM4Vi3Th20aW1GAqKCAZE6-dRCaCqrzyiH_9DD2nNsQ5iqBCMC4BWVIqeKJtTKdl5M-cw1SUZSswxU3PK1NRMzSnTqvlwdl77Y-tJ8RRi-whocaBT</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Perisinakis, Kostas</creator><creator>Seimenis, Ioannis</creator><creator>Tzedakis, Antonis</creator><creator>Damilakis, John</creator><general>Society of Nuclear Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>201408</creationdate><title>Perfusion scintigraphy versus 256-slice CT angiography in pregnant patients suspected of pulmonary embolism: comparison of radiation risks</title><author>Perisinakis, Kostas ; Seimenis, Ioannis ; Tzedakis, Antonis ; Damilakis, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-b41256d56e97ee9192cdcf4b7f748b98127ff022cdd770b5c4f92075b8477ec13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angiography - adverse effects</topic><topic>Autoradiography</topic><topic>Child</topic><topic>Female</topic><topic>Fetus - radiation effects</topic><topic>Humans</topic><topic>Lung - blood supply</topic><topic>Lung - diagnostic imaging</topic><topic>Medical imaging</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>Perfusion Imaging - adverse effects</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - diagnostic imaging</topic><topic>Prenatal Exposure Delayed Effects - etiology</topic><topic>Pulmonary Embolism - diagnostic imaging</topic><topic>Radiation therapy</topic><topic>Regional Blood Flow</topic><topic>Risk Assessment</topic><topic>Simulation</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perisinakis, Kostas</creatorcontrib><creatorcontrib>Seimenis, Ioannis</creatorcontrib><creatorcontrib>Tzedakis, Antonis</creatorcontrib><creatorcontrib>Damilakis, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perisinakis, Kostas</au><au>Seimenis, Ioannis</au><au>Tzedakis, Antonis</au><au>Damilakis, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfusion scintigraphy versus 256-slice CT angiography in pregnant patients suspected of pulmonary embolism: comparison of radiation risks</atitle><jtitle>Journal of Nuclear Medicine</jtitle><addtitle>J Nucl Med</addtitle><date>2014-08</date><risdate>2014</risdate><volume>55</volume><issue>8</issue><spage>1273</spage><epage>1280</epage><pages>1273-1280</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><eissn>2159-662X</eissn><coden>JNMEAQ</coden><abstract>One aim of the current study was to determine normalized dose data for maternal radiosensitive organs and embryo/fetus from 256-slice CT pulmonary angiography (CTPA) performed on pregnant patients suspected of having pulmonary embolism. A second aim was to provide reliable maternal and fetal doses and associated radiation cancer risk estimates from 256-slice CTPA and lung perfusion scintigraphy (LPS) for comparison.
Mathematic anthropomorphic phantoms were generated to simulate the average woman at early pregnancy and at the third, sixth, and ninth months of gestation. In each phantom, 0-3 additional 1.5-cm-thick fat tissue layers were added to derive 4 phantoms representing pregnant women with different body sizes. Monte Carlo methods were used to simulate low-dose 256-slice CTPA exposures on each of the 16 generated phantoms. Normalized organ and embryo/fetal dose data were derived for exposures at 80, 100, and 120 kV. Maternal effective dose and embryo/fetal dose from 256-slice CTPA and associated lifetime attributable risks of radiation cancer were determined for different body sizes and gestational stages and compared with corresponding data from LPS.
For an average-sized pregnant patient at the first trimester, the 256-slice CTPA exposure resulted in a maternal effective dose of 1 mSv and an embryo/fetal dose of 0.05 mGy. However, maternal effective dose considerably increased with body size, whereas embryo/fetal dose increased with both body size and gestational stage. Compared with LPS, low-dose CTPA to an average-sized pregnant patient resulted in a 30% higher maternal effective dose but a 3.4-6 times lower embryo/fetal dose. Nevertheless, LPS was associated with less aggregated radiation risk for an average-sized pregnant patient, with the difference from CTPA being increased further for larger patients.
Compared with CTPA performed with a modern wide-area CT scanner, LPS remains comparatively more dose-efficient.</abstract><cop>United States</cop><pub>Society of Nuclear Medicine</pub><pmid>24876205</pmid><doi>10.2967/jnumed.114.137968</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiography - adverse effects Autoradiography Child Female Fetus - radiation effects Humans Lung - blood supply Lung - diagnostic imaging Medical imaging Neoplasms, Radiation-Induced - etiology Perfusion Imaging - adverse effects Pregnancy Pregnancy Complications - diagnostic imaging Prenatal Exposure Delayed Effects - etiology Pulmonary Embolism - diagnostic imaging Radiation therapy Regional Blood Flow Risk Assessment Simulation Tissues |
| title | Perfusion scintigraphy versus 256-slice CT angiography in pregnant patients suspected of pulmonary embolism: comparison of radiation risks |
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