DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs

Background: Little is known about epigenetic alterations associated with subcutaneous adipose tissue (SAT) in obesity. Our aim was to study genome-wide DNA methylation and gene expression differences in SAT in monozygotic (MZ) twin pairs who are discordant for body mass index (BMI). This design comp...

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Veröffentlicht in:	International Journal of Obesity 2016-04, Vol.40 (4), p.654-661
Hauptverfasser:	Pietiläinen, K H, Ismail, K, Järvinen, E, Heinonen, S, Tummers, M, Bollepalli, S, Lyle, R, Muniandy, M, Moilanen, E, Hakkarainen, A, Lundbom, J, Lundbom, N, Rissanen, A, Kaprio, J, Ollikainen, M
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 38/61 38/90 631/208 631/208/176/1988 631/208/199 692/699/2743/393 692/700/139/2818 82 82/51 96 Adipogenesis Adipose tissue Adipose tissues Analysis Body composition Body Composition - genetics Body fat Body Mass Index Body size C-reactive protein CpG islands Deoxyribonucleic acid DNA DNA Methylation Dyslipidemia Epidemiology Epigenetic inheritance Epigenetics Extracellular matrix Female Finland Gene expression Gene Expression Profiling Genes Genomes Glucose tolerance Health Promotion and Disease Prevention Humans Inflammation Insulin Insulin resistance Insulin Resistance - genetics Internal Medicine Lipids Magnetic resonance imaging Male Medicine Medicine & Public Health Metabolic Diseases Methylation Obesity Obesity - genetics Obesity - metabolism Obesity - physiopathology original-article Public Health Receptors, Interleukin-6 - metabolism Spectroscopy Subcutaneous Fat - metabolism Thinness - genetics Thinness - metabolism Thinness - physiopathology Tumor Necrosis Factor-alpha - metabolism Twins Twins, Monozygotic Young Adult Young adults
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