Mesenchymal stem cell-mediated, tumor stroma-targeted radioiodine therapy of metastatic colon cancer using the sodium iodide symporter as theranostic gene

The tumor-homing property of mesenchymal stem cells (MSCs) allows targeted delivery of therapeutic genes into the tumor microenvironment. The application of sodium iodide symporter (NIS) as a theranostic gene allows noninvasive imaging of MSC biodistribution and transgene expression before therapeut...

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Veröffentlicht in:	Journal of Nuclear Medicine 2015-04, Vol.56 (4), p.600-606
Hauptverfasser:	Knoop, Kerstin, Schwenk, Nathalie, Schmohl, Kathrin, Müller, Andrea, Zach, Christian, Cyran, Clemens, Carlsen, Janette, Böning, Guido, Bartenstein, Peter, Göke, Burkhard, Wagner, Ernst, Nelson, Peter J, Spitzweg, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Chemokine CCL5 - metabolism Colonic Neoplasms - radiotherapy Colorectal cancer Female Fibroblasts - metabolism Genetic Therapy - methods Humans Iodine Radioisotopes - therapeutic use Liver Neoplasms - radiotherapy Magnetic Resonance Imaging Mesenchymal Stromal Cells - cytology Metastasis Mice Mice, Nude Neoplasm Metastasis Neoplasm Transplantation Nuclear medicine Plasmids - metabolism Positron-Emission Tomography Radiation therapy Radionuclide Imaging Stem cells Symporters - chemistry Symporters - genetics Transgenes Tumor Microenvironment Tumors
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