Echinocystic Acid Inhibits IL-1β-Induced COX-2 and iNOS Expression in Human Osteoarthritis Chondrocytes

Echinocystic acid (EA), a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects. However, the effect of EA on IL-1β-stimulated osteoarthritis chondrocyte has not been reported. The...

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Veröffentlicht in:	Inflammation 2016-04, Vol.39 (2), p.543-549
Hauptverfasser:	Ma, Zhiqiang, Wang, Yanlong, Piao, Taikui, Liu, Jianyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Biomedical and Life Sciences Biomedicine Cartilage, Articular - cytology Cells, Cultured Chondrocytes - cytology Chondrocytes - metabolism Cyclooxygenase 2 - biosynthesis Dinoprostone - metabolism Enzyme Activation - drug effects Extracellular Signal-Regulated MAP Kinases - biosynthesis Gleditsia Humans Immunology Interleukin-1beta - antagonists & inhibitors Internal Medicine JNK Mitogen-Activated Protein Kinases - biosynthesis Matrix Metalloproteinase 13 - metabolism Middle Aged NF-kappa B - biosynthesis NF-KappaB Inhibitor alpha - biosynthesis Nitric Oxide - metabolism Nitric Oxide Synthase Type II - biosynthesis Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology Original Article Osteoarthritis - drug therapy Osteoarthritis - metabolism p38 Mitogen-Activated Protein Kinases - biosynthesis Pathology Pharmacology/Toxicology Rheumatology
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