The Use of p-Aminobenzoic Acid as a Probe Substance for the Targeted Profiling of Glycine Conjugation

ABSTRACT Glycine conjugation facilitates the metabolism of toxic aromatic acids, capable of disrupting mitochondrial integrity. Owing to the high exposure to toxic substrates, characterization of individual glycine conjugation capacity, and its regulatory factors has become increasingly important. A...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2016-03, Vol.30 (3), p.136-147
Hauptverfasser:	Nortje, Carla, van der Sluis, Rencia, van Dijk, Alberdina Aike, Erasmus, Elardus
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobenzoic Acid - administration & dosage 4-Aminobenzoic Acid - urine Acids Enzymes Glycine - metabolism Glycine conjugation glycine N-acyltransferase Hippurates - metabolism Humans Metabolism Molecular Probes p-Aminobenzoic acid p-Aminohippuric acid
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