Role of Lipid Infiltration of Hepatocytes in the Morphogenesis of Chronic Hepatitis C
Immunohistochemical and PCR analysis of the structure of lipid-containing hepatocytes and replication of chronic hepatitis C viral particles revealed no positive correlation between the presence of HCV RNA in blood specimens, number of infected hepatocytes (by expression of HCV NS3Ag) with clinical...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2013-12, Vol.156 (2), p.281-284 |
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| creator | Nepomnyashchikh, G. I. Bakarev, M. A. Nepomnyashchikh, D. L. Yudanov, A. V. Kapustina, V. I. Migus’kova, E. I. Postnikova, O. A. Vinogradova, E. V. Nokhrina, Zh. V. Savchenko, S. A. |
| description | Immunohistochemical and PCR analysis of the structure of lipid-containing hepatocytes and replication of chronic hepatitis C viral particles revealed no positive correlation between the presence of HCV RNA in blood specimens, number of infected hepatocytes (by expression of HCV NS3Ag) with clinical biochemical parameters and intensity of structural changes in biopsy specimens. Small-vesicular subcytolemmal lipid infiltration of hepatocytes was detected, presumably associated with hepatitis C virus replication phase. Characteristic subcytolemmal location of the lipid droplets can reflect their involvement in virus transport from the cell and indicate a virus-induced nature of lipid metabolism disorders. |
| doi_str_mv | 10.1007/s10517-013-2330-y |
| format | Article |
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Characteristic subcytolemmal location of the lipid droplets can reflect their involvement in virus transport from the cell and indicate a virus-induced nature of lipid metabolism disorders.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-013-2330-y</identifier><identifier>PMID: 24319768</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cholesterol ; Female ; Genotype ; Hepacivirus - genetics ; Hepacivirus - growth & development ; Hepatitis C virus ; Hepatitis C, Chronic - pathology ; Hepatitis C, Chronic - virology ; Hepatocytes - pathology ; Hepatocytes - virology ; Humans ; Immunohistochemistry ; Internal Medicine ; Laboratory Medicine ; Lipid Metabolism ; Liver - cytology ; Liver - pathology ; Liver - virology ; Male ; Middle Aged ; Pathology ; Physiological aspects ; RNA ; RNA, Viral - blood ; Viral Nonstructural Proteins - biosynthesis ; Virus Replication ; Young Adult</subject><ispartof>Bulletin of experimental biology and medicine, 2013-12, Vol.156 (2), p.281-284</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c455t-30ec3098f8f6c31fc2d86958ce136d54c04fd80ca57e461c0d2698afe64777ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-013-2330-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-013-2330-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24319768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nepomnyashchikh, G. 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Characteristic subcytolemmal location of the lipid droplets can reflect their involvement in virus transport from the cell and indicate a virus-induced nature of lipid metabolism disorders.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cholesterol</subject><subject>Female</subject><subject>Genotype</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - growth & development</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - pathology</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Hepatocytes - pathology</subject><subject>Hepatocytes - virology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Lipid Metabolism</subject><subject>Liver - cytology</subject><subject>Liver - pathology</subject><subject>Liver - virology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Physiological aspects</subject><subject>RNA</subject><subject>RNA, Viral - blood</subject><subject>Viral Nonstructural Proteins - biosynthesis</subject><subject>Virus Replication</subject><subject>Young Adult</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk1rFTEYhYMo9lr9AW5kQChupuZj8jHLcrG2cEUQuw4x8-ZOytxkTGYW99-bYaq2YilZhCTPe-CcHITeEnxOMJYfM8GcyBoTVlPGcH18hjaES1YrSslztMEFqhul1Al6lfPtcsSCvEQntGGklUJt0M23OEAVXbXzo--q6-D8MCUz-RiW2ysYzRTtcYJc-VBNPVRfYhr7uIcA2eeF2fYpBm9X1k_lcvsavXBmyPDmbj9FN5efvm-v6t3Xz9fbi11tG86nmmGwDLfKKScsI87STomWKwuEiY43FjeuU9gaLqERxOKOilYZB6KRUgKwU_Rh1R1T_DlDnvTBZwvDYALEOWsiVUmoZcXvk2gjBJOCc1zQ9_-gt3FOoRgpgpJRykuMf6m9GUD74GLJzS6i-oIVgi16hTr_D1VWBwdvY4CSNzwcOLs30IMZpj7HYV5-JD8EyQraFHNO4PSY_MGkoyZYL_XQaz10qYde6qGPZebdnbP5xwG6PxO_-1AAugK5PIU9pHvWH1X9BVVGwVw</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Nepomnyashchikh, G. 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| subjects | Adult Aged Biomedical and Life Sciences Biomedicine Cell Biology Cholesterol Female Genotype Hepacivirus - genetics Hepacivirus - growth & development Hepatitis C virus Hepatitis C, Chronic - pathology Hepatitis C, Chronic - virology Hepatocytes - pathology Hepatocytes - virology Humans Immunohistochemistry Internal Medicine Laboratory Medicine Lipid Metabolism Liver - cytology Liver - pathology Liver - virology Male Middle Aged Pathology Physiological aspects RNA RNA, Viral - blood Viral Nonstructural Proteins - biosynthesis Virus Replication Young Adult |
| title | Role of Lipid Infiltration of Hepatocytes in the Morphogenesis of Chronic Hepatitis C |
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