Effect of Peripheral Opioid Receptor Agonists on Depressive Activity of Ethanol
We studied the effect of peripheral μ- and κ-opioid receptor agonists (not crossing the bloodbrain barrier) on locomotor activity and metabolism in rats after acute administration of ethanol. Intraperitoneal injection of ethanol in a single dose of 2 g/kg had a strong depressive effect manifested in...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2014-04, Vol.156 (6), p.778-780 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Trigub, M. M. Bogdanova, N. G. Kolpakov, A. A. Bashkatova, V. G. Sudakov, S. K. |
| description | We studied the effect of peripheral μ- and κ-opioid receptor agonists (not crossing the bloodbrain barrier) on locomotor activity and metabolism in rats after acute administration of ethanol. Intraperitoneal injection of ethanol in a single dose of 2 g/kg had a strong depressive effect manifested in a decrease in horizontal locomotor activity and suppression of metabolism. μ-Opioid receptor agonist DAMGO and κ-opioid receptor agonist ICI 204,448 partly abolished the effect of ethanol on locomotor activity of rats. ICI 204,448 was most potent in this respect. In contrast to μ-opioid receptor agonist DAMGO, κ-opioid receptor agonist ICI 204,448 prevented metabolism suppression induced by ethanol. Our results indicate that ICI 204,448 signifi cantly inhibits the depressive effect of ethanol. DAMGO showed only partial effectiveness under these experimental conditions. |
| doi_str_mv | 10.1007/s10517-014-2448-6 |
| format | Article |
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M. ; Bogdanova, N. G. ; Kolpakov, A. A. ; Bashkatova, V. G. ; Sudakov, S. K.</creator><creatorcontrib>Trigub, M. M. ; Bogdanova, N. G. ; Kolpakov, A. A. ; Bashkatova, V. G. ; Sudakov, S. K.</creatorcontrib><description>We studied the effect of peripheral μ- and κ-opioid receptor agonists (not crossing the bloodbrain barrier) on locomotor activity and metabolism in rats after acute administration of ethanol. Intraperitoneal injection of ethanol in a single dose of 2 g/kg had a strong depressive effect manifested in a decrease in horizontal locomotor activity and suppression of metabolism. μ-Opioid receptor agonist DAMGO and κ-opioid receptor agonist ICI 204,448 partly abolished the effect of ethanol on locomotor activity of rats. ICI 204,448 was most potent in this respect. In contrast to μ-opioid receptor agonist DAMGO, κ-opioid receptor agonist ICI 204,448 prevented metabolism suppression induced by ethanol. Our results indicate that ICI 204,448 signifi cantly inhibits the depressive effect of ethanol. DAMGO showed only partial effectiveness under these experimental conditions.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-014-2448-6</identifier><identifier>PMID: 24824695</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Alcohol ; Alcohol, Denatured ; Analgesics, Opioid - therapeutic use ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood-Brain Barrier - metabolism ; Cell Biology ; Central Nervous System Depressants - pharmacology ; Energy Metabolism - drug effects ; Enkephalin, Ala-MePhe-Gly- - therapeutic use ; Ethanol - pharmacology ; Internal Medicine ; Laboratory Medicine ; Male ; Motor Activity - drug effects ; Pathology ; Physiological aspects ; Pyrrolidines - therapeutic use ; Rats ; Rats, Wistar ; Receptors, Opioid, kappa - agonists ; Receptors, Opioid, mu - agonists</subject><ispartof>Bulletin of experimental biology and medicine, 2014-04, Vol.156 (6), p.778-780</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-2114b078087737c9c100d83574484b994060dd301583390a03c25ed1fb46c36f3</citedby><cites>FETCH-LOGICAL-c503t-2114b078087737c9c100d83574484b994060dd301583390a03c25ed1fb46c36f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-014-2448-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-014-2448-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24824695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trigub, M. M.</creatorcontrib><creatorcontrib>Bogdanova, N. G.</creatorcontrib><creatorcontrib>Kolpakov, A. A.</creatorcontrib><creatorcontrib>Bashkatova, V. G.</creatorcontrib><creatorcontrib>Sudakov, S. K.</creatorcontrib><title>Effect of Peripheral Opioid Receptor Agonists on Depressive Activity of Ethanol</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effect of peripheral μ- and κ-opioid receptor agonists (not crossing the bloodbrain barrier) on locomotor activity and metabolism in rats after acute administration of ethanol. Intraperitoneal injection of ethanol in a single dose of 2 g/kg had a strong depressive effect manifested in a decrease in horizontal locomotor activity and suppression of metabolism. μ-Opioid receptor agonist DAMGO and κ-opioid receptor agonist ICI 204,448 partly abolished the effect of ethanol on locomotor activity of rats. ICI 204,448 was most potent in this respect. In contrast to μ-opioid receptor agonist DAMGO, κ-opioid receptor agonist ICI 204,448 prevented metabolism suppression induced by ethanol. Our results indicate that ICI 204,448 signifi cantly inhibits the depressive effect of ethanol. DAMGO showed only partial effectiveness under these experimental conditions.</description><subject>Alcohol</subject><subject>Alcohol, Denatured</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Cell Biology</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Energy Metabolism - drug effects</subject><subject>Enkephalin, Ala-MePhe-Gly- - therapeutic use</subject><subject>Ethanol - pharmacology</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Pathology</subject><subject>Physiological aspects</subject><subject>Pyrrolidines - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Opioid, kappa - agonists</subject><subject>Receptors, Opioid, mu - agonists</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl9rFDEUxYModlv9AL7IgCB9mZq_k8zj0m6rUNgi-hxmMze7KbPJmGQK_fZm2FpbUSQPl-T-zoETDkLvCD4jGMtPiWBBZI0Jrynnqm5eoAURktWKUvISLXCBaq6UOkLHKd3OV9yQ1-iIckV504oFWq-sBZOrYKsbiG7cQeyGaj264PrqKxgYc4jVchu8SzlVwVcXMEZIyd1BtTTZ3bl8P6tXedf5MLxBr2w3JHj7ME_Q98vVt_PP9fX66sv58ro2ArNcU0L4BkuFlZRMmtaUPL1iQpYYfNO2HDe47xkmQjHW4g4zQwX0xG54Y1hj2Qk6PfiOMfyYIGW9d8nAMHQewpQ0Kd6CtFSy_6Ni_g4qWlnQD3-gt2GKvgQphpJRxgjDv6ltN4B23oYcOzOb6iWTmBLKRVOos79Q5fSwdyZ4sK68PxN8fCLYQTfkXQrDlF3w6TlIDqCJIaUIVo_R7bt4rwnWczH0oRi6FEPPxdCz5v1Dsmmzh_5R8asJBaAHIJWV30J8Ev2frj8BriS8ww</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Trigub, M. 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Intraperitoneal injection of ethanol in a single dose of 2 g/kg had a strong depressive effect manifested in a decrease in horizontal locomotor activity and suppression of metabolism. μ-Opioid receptor agonist DAMGO and κ-opioid receptor agonist ICI 204,448 partly abolished the effect of ethanol on locomotor activity of rats. ICI 204,448 was most potent in this respect. In contrast to μ-opioid receptor agonist DAMGO, κ-opioid receptor agonist ICI 204,448 prevented metabolism suppression induced by ethanol. Our results indicate that ICI 204,448 signifi cantly inhibits the depressive effect of ethanol. DAMGO showed only partial effectiveness under these experimental conditions.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24824695</pmid><doi>10.1007/s10517-014-2448-6</doi><tpages>3</tpages></addata></record> |
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| subjects | Alcohol Alcohol, Denatured Analgesics, Opioid - therapeutic use Animals Biomedical and Life Sciences Biomedicine Blood-Brain Barrier - metabolism Cell Biology Central Nervous System Depressants - pharmacology Energy Metabolism - drug effects Enkephalin, Ala-MePhe-Gly- - therapeutic use Ethanol - pharmacology Internal Medicine Laboratory Medicine Male Motor Activity - drug effects Pathology Physiological aspects Pyrrolidines - therapeutic use Rats Rats, Wistar Receptors, Opioid, kappa - agonists Receptors, Opioid, mu - agonists |
| title | Effect of Peripheral Opioid Receptor Agonists on Depressive Activity of Ethanol |
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