Siah2-deficient mice show impaired skin wound repair

Hypoxia is associated with the dermal wound healing process and hypoxia signaling is presumed to be crucial for normal wound repair. The Siah2 ubiquitin ligase controls the abundance of hypoxia‐inducible factor‐1 alpha, and loss of Siah2 results in destabilization of hypoxia‐inducible factor‐1 alpha...

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Veröffentlicht in:	Wound repair and regeneration 2013-05, Vol.21 (3), p.437-447
Hauptverfasser:	Musyoka, James N., Liu, Mira C.P., Pouniotis, Dodie S., Wong, Christina S.F., Bowtell, David D., Little, Peter J., Getachew, Robel, Möller, Andreas, Darby, Ian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Movement Cells, Cultured Disease Models, Animal Female Fibroblasts - pathology Follow-Up Studies Hypoxia - metabolism Hypoxia - pathology Immunohistochemistry Male Mice Mice, Inbred C57BL Ubiquitin-Protein Ligases - deficiency Wound Healing - physiology Wounds and Injuries - metabolism Wounds and Injuries - pathology
Online-Zugang:	Volltext
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