FGF-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients
Purpose High fibroblast growth factor-23 (FGF-23) levels are associated with mortality and cardiovascular events in patients with chronic kidney disease. The aim of this cross-sectional study was to investigate the relationship between plasma FGF-23 levels and coronary artery calcification and carot...
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| Veröffentlicht in: | International urology and nephrology 2016-04, Vol.48 (4), p.609-617 |
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| creator | Turan, Mehmet Nuri Kircelli, Fatih Yaprak, Mustafa Sisman, Ali Riza Gungor, Ozkan Bayraktaroglu, Selen Ozkahya, Mehmet Asci, Gulay Floege, Jurgen Ok, Ercan |
| description | Purpose
High fibroblast growth factor-23 (FGF-23) levels are associated with mortality and cardiovascular events in patients with chronic kidney disease. The aim of this cross-sectional study was to investigate the relationship between plasma FGF-23 levels and coronary artery calcification and carotid artery intima-media thickness (CA-IMT) in hemodialysis (HD) patients.
Methods
In this cross-sectional study, plasma intact FGF-23 levels were measured in 229 patients who underwent coronary artery calcification scores (CACs) determined by multi-slice computerized tomography and CA-IMT assessed by using high-resolution color Doppler ultrasonography.
Results
Median FGF-23 was 53.5 pg/ml (IQR 30.8–249.5). Median CACs was 98 (IQR 0–531), and the frequency of patients with severe calcification (CACs > 400) was 28.8 %; 27.5 % of cases had no calcification. Mean CA-IMT was 0.78 ± 0.20 mm, and the presence of carotid plaques was 51 % with a mean length 2.1 mm. FGF-23 level was positively correlated with serum calcium (
r
= 0.337,
p
|
| doi_str_mv | 10.1007/s11255-016-1231-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1780519063</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3988854371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-728416b81d78b1cede1a75cafd9b7c8c58d11b81fa92fa77c483e7b9a56545663</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMo9lr9AW4k4MZFR3OSyccspXirUOimXYdM5ow3JXfmmmRa-u_NdaqIIHSTwDnPew7JQ8hbYB-BMf0pA3ApGwaqAS6ggWdkA1KLhkvTPicbJlgtKi5OyKucbxljnWHsJTnhyigJWm_IYXuxbbigEe8wZuoSUpfz7IMrOND7UHb0zmW_RJeod9GHMXhXwjyd0X4pdJrLCrmywzRnH49nyGc0THSH-3kILj7UAj3UFE4lvyYvRhczvnm8T8nN9sv1-dfm8uri2_nny8a3WpZGc9OC6g0M2vTgcUBwWno3Dl2vvfHSDAC1PbqOj05r3xqBuu-cVLKVSolT8mGde0jzjwVzsfuQPcboJpyXbEEbJqFjSjwB1a3kRnNe0ff_oLfzkqb6kF9U1SGMqRSslK-fkROO9pDC3qUHC8wezdnVnK3m7NGchZp59zh56fc4_En8VlUBvgK5tqbvmP5a_d-pPwGBKaM-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1774125388</pqid></control><display><type>article</type><title>FGF-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients</title><source>MEDLINE</source><source>Springer Journals</source><creator>Turan, Mehmet Nuri ; Kircelli, Fatih ; Yaprak, Mustafa ; Sisman, Ali Riza ; Gungor, Ozkan ; Bayraktaroglu, Selen ; Ozkahya, Mehmet ; Asci, Gulay ; Floege, Jurgen ; Ok, Ercan</creator><creatorcontrib>Turan, Mehmet Nuri ; Kircelli, Fatih ; Yaprak, Mustafa ; Sisman, Ali Riza ; Gungor, Ozkan ; Bayraktaroglu, Selen ; Ozkahya, Mehmet ; Asci, Gulay ; Floege, Jurgen ; Ok, Ercan</creatorcontrib><description>Purpose
High fibroblast growth factor-23 (FGF-23) levels are associated with mortality and cardiovascular events in patients with chronic kidney disease. The aim of this cross-sectional study was to investigate the relationship between plasma FGF-23 levels and coronary artery calcification and carotid artery intima-media thickness (CA-IMT) in hemodialysis (HD) patients.
Methods
In this cross-sectional study, plasma intact FGF-23 levels were measured in 229 patients who underwent coronary artery calcification scores (CACs) determined by multi-slice computerized tomography and CA-IMT assessed by using high-resolution color Doppler ultrasonography.
Results
Median FGF-23 was 53.5 pg/ml (IQR 30.8–249.5). Median CACs was 98 (IQR 0–531), and the frequency of patients with severe calcification (CACs > 400) was 28.8 %; 27.5 % of cases had no calcification. Mean CA-IMT was 0.78 ± 0.20 mm, and the presence of carotid plaques was 51 % with a mean length 2.1 mm. FGF-23 level was positively correlated with serum calcium (
r
= 0.337,
p
< 0.001), phosphate (
r
= 0.397,
p
< 0.001) and CACs (
r
= 0.218,
p
= 0.001). Neither CA-IMT nor the presence of carotid artery plaques correlated with FGF-23 levels. In adjusted ordinal regression analysis, FGF-23 level was an independent predictor for severe CACs together with age, gender, presence of diabetes, time on dialysis and CA-IMT (model
r
2
= 0.44,
p
< 0.001). As a novel finding, the mean CACs was markedly higher in patients with FGF-23 level above median regardless of phosphate levels (
p
= 0.03).
Conclusions
In HD patients, plasma FGF-23 level is superior to phosphate in the prediction of coronary artery calcification. However, FGF-23 is not associated with carotid artery atherosclerosis in HD patients.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-016-1231-1</identifier><identifier>PMID: 26865177</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aorta, Thoracic - diagnostic imaging ; Aorta, Thoracic - physiopathology ; Atherosclerosis - blood ; Atherosclerosis - complications ; Atherosclerosis - diagnosis ; Carotid Intima-Media Thickness ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - etiology ; Cross-Sectional Studies ; Electrocardiography ; Enzyme-Linked Immunosorbent Assay ; Female ; Fibroblast Growth Factors - blood ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Nephrology - Original Paper ; Renal Dialysis ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - therapy ; Tomography, X-Ray Computed ; Ultrasonography, Doppler, Color ; Urology ; Vascular Calcification - blood ; Vascular Calcification - diagnosis ; Vascular Calcification - etiology ; Young Adult</subject><ispartof>International urology and nephrology, 2016-04, Vol.48 (4), p.609-617</ispartof><rights>Springer Science+Business Media Dordrecht 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-728416b81d78b1cede1a75cafd9b7c8c58d11b81fa92fa77c483e7b9a56545663</citedby><cites>FETCH-LOGICAL-c475t-728416b81d78b1cede1a75cafd9b7c8c58d11b81fa92fa77c483e7b9a56545663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-016-1231-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-016-1231-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26865177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turan, Mehmet Nuri</creatorcontrib><creatorcontrib>Kircelli, Fatih</creatorcontrib><creatorcontrib>Yaprak, Mustafa</creatorcontrib><creatorcontrib>Sisman, Ali Riza</creatorcontrib><creatorcontrib>Gungor, Ozkan</creatorcontrib><creatorcontrib>Bayraktaroglu, Selen</creatorcontrib><creatorcontrib>Ozkahya, Mehmet</creatorcontrib><creatorcontrib>Asci, Gulay</creatorcontrib><creatorcontrib>Floege, Jurgen</creatorcontrib><creatorcontrib>Ok, Ercan</creatorcontrib><title>FGF-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Purpose
High fibroblast growth factor-23 (FGF-23) levels are associated with mortality and cardiovascular events in patients with chronic kidney disease. The aim of this cross-sectional study was to investigate the relationship between plasma FGF-23 levels and coronary artery calcification and carotid artery intima-media thickness (CA-IMT) in hemodialysis (HD) patients.
Methods
In this cross-sectional study, plasma intact FGF-23 levels were measured in 229 patients who underwent coronary artery calcification scores (CACs) determined by multi-slice computerized tomography and CA-IMT assessed by using high-resolution color Doppler ultrasonography.
Results
Median FGF-23 was 53.5 pg/ml (IQR 30.8–249.5). Median CACs was 98 (IQR 0–531), and the frequency of patients with severe calcification (CACs > 400) was 28.8 %; 27.5 % of cases had no calcification. Mean CA-IMT was 0.78 ± 0.20 mm, and the presence of carotid plaques was 51 % with a mean length 2.1 mm. FGF-23 level was positively correlated with serum calcium (
r
= 0.337,
p
< 0.001), phosphate (
r
= 0.397,
p
< 0.001) and CACs (
r
= 0.218,
p
= 0.001). Neither CA-IMT nor the presence of carotid artery plaques correlated with FGF-23 levels. In adjusted ordinal regression analysis, FGF-23 level was an independent predictor for severe CACs together with age, gender, presence of diabetes, time on dialysis and CA-IMT (model
r
2
= 0.44,
p
< 0.001). As a novel finding, the mean CACs was markedly higher in patients with FGF-23 level above median regardless of phosphate levels (
p
= 0.03).
Conclusions
In HD patients, plasma FGF-23 level is superior to phosphate in the prediction of coronary artery calcification. However, FGF-23 is not associated with carotid artery atherosclerosis in HD patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aorta, Thoracic - diagnostic imaging</subject><subject>Aorta, Thoracic - physiopathology</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - diagnosis</subject><subject>Carotid Intima-Media Thickness</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - etiology</subject><subject>Cross-Sectional Studies</subject><subject>Electrocardiography</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fibroblast Growth Factors - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Tomography, X-Ray Computed</subject><subject>Ultrasonography, Doppler, Color</subject><subject>Urology</subject><subject>Vascular Calcification - blood</subject><subject>Vascular Calcification - diagnosis</subject><subject>Vascular Calcification - etiology</subject><subject>Young Adult</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1rFTEUhoMo9lr9AW4k4MZFR3OSyccspXirUOimXYdM5ow3JXfmmmRa-u_NdaqIIHSTwDnPew7JQ8hbYB-BMf0pA3ApGwaqAS6ggWdkA1KLhkvTPicbJlgtKi5OyKucbxljnWHsJTnhyigJWm_IYXuxbbigEe8wZuoSUpfz7IMrOND7UHb0zmW_RJeod9GHMXhXwjyd0X4pdJrLCrmywzRnH49nyGc0THSH-3kILj7UAj3UFE4lvyYvRhczvnm8T8nN9sv1-dfm8uri2_nny8a3WpZGc9OC6g0M2vTgcUBwWno3Dl2vvfHSDAC1PbqOj05r3xqBuu-cVLKVSolT8mGde0jzjwVzsfuQPcboJpyXbEEbJqFjSjwB1a3kRnNe0ff_oLfzkqb6kF9U1SGMqRSslK-fkROO9pDC3qUHC8wezdnVnK3m7NGchZp59zh56fc4_En8VlUBvgK5tqbvmP5a_d-pPwGBKaM-</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Turan, Mehmet Nuri</creator><creator>Kircelli, Fatih</creator><creator>Yaprak, Mustafa</creator><creator>Sisman, Ali Riza</creator><creator>Gungor, Ozkan</creator><creator>Bayraktaroglu, Selen</creator><creator>Ozkahya, Mehmet</creator><creator>Asci, Gulay</creator><creator>Floege, Jurgen</creator><creator>Ok, Ercan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>FGF-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients</title><author>Turan, Mehmet Nuri ; Kircelli, Fatih ; Yaprak, Mustafa ; Sisman, Ali Riza ; Gungor, Ozkan ; Bayraktaroglu, Selen ; Ozkahya, Mehmet ; Asci, Gulay ; Floege, Jurgen ; Ok, Ercan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-728416b81d78b1cede1a75cafd9b7c8c58d11b81fa92fa77c483e7b9a56545663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aorta, Thoracic - diagnostic imaging</topic><topic>Aorta, Thoracic - physiopathology</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - diagnosis</topic><topic>Carotid Intima-Media Thickness</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - etiology</topic><topic>Cross-Sectional Studies</topic><topic>Electrocardiography</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fibroblast Growth Factors - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Renal Dialysis</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Tomography, X-Ray Computed</topic><topic>Ultrasonography, Doppler, Color</topic><topic>Urology</topic><topic>Vascular Calcification - blood</topic><topic>Vascular Calcification - diagnosis</topic><topic>Vascular Calcification - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turan, Mehmet Nuri</creatorcontrib><creatorcontrib>Kircelli, Fatih</creatorcontrib><creatorcontrib>Yaprak, Mustafa</creatorcontrib><creatorcontrib>Sisman, Ali Riza</creatorcontrib><creatorcontrib>Gungor, Ozkan</creatorcontrib><creatorcontrib>Bayraktaroglu, Selen</creatorcontrib><creatorcontrib>Ozkahya, Mehmet</creatorcontrib><creatorcontrib>Asci, Gulay</creatorcontrib><creatorcontrib>Floege, Jurgen</creatorcontrib><creatorcontrib>Ok, Ercan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turan, Mehmet Nuri</au><au>Kircelli, Fatih</au><au>Yaprak, Mustafa</au><au>Sisman, Ali Riza</au><au>Gungor, Ozkan</au><au>Bayraktaroglu, Selen</au><au>Ozkahya, Mehmet</au><au>Asci, Gulay</au><au>Floege, Jurgen</au><au>Ok, Ercan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FGF-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>48</volume><issue>4</issue><spage>609</spage><epage>617</epage><pages>609-617</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract>Purpose
High fibroblast growth factor-23 (FGF-23) levels are associated with mortality and cardiovascular events in patients with chronic kidney disease. The aim of this cross-sectional study was to investigate the relationship between plasma FGF-23 levels and coronary artery calcification and carotid artery intima-media thickness (CA-IMT) in hemodialysis (HD) patients.
Methods
In this cross-sectional study, plasma intact FGF-23 levels were measured in 229 patients who underwent coronary artery calcification scores (CACs) determined by multi-slice computerized tomography and CA-IMT assessed by using high-resolution color Doppler ultrasonography.
Results
Median FGF-23 was 53.5 pg/ml (IQR 30.8–249.5). Median CACs was 98 (IQR 0–531), and the frequency of patients with severe calcification (CACs > 400) was 28.8 %; 27.5 % of cases had no calcification. Mean CA-IMT was 0.78 ± 0.20 mm, and the presence of carotid plaques was 51 % with a mean length 2.1 mm. FGF-23 level was positively correlated with serum calcium (
r
= 0.337,
p
< 0.001), phosphate (
r
= 0.397,
p
< 0.001) and CACs (
r
= 0.218,
p
= 0.001). Neither CA-IMT nor the presence of carotid artery plaques correlated with FGF-23 levels. In adjusted ordinal regression analysis, FGF-23 level was an independent predictor for severe CACs together with age, gender, presence of diabetes, time on dialysis and CA-IMT (model
r
2
= 0.44,
p
< 0.001). As a novel finding, the mean CACs was markedly higher in patients with FGF-23 level above median regardless of phosphate levels (
p
= 0.03).
Conclusions
In HD patients, plasma FGF-23 level is superior to phosphate in the prediction of coronary artery calcification. However, FGF-23 is not associated with carotid artery atherosclerosis in HD patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26865177</pmid><doi>10.1007/s11255-016-1231-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | International urology and nephrology, 2016-04, Vol.48 (4), p.609-617 |
| issn | 0301-1623 1573-2584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1780519063 |
| source | MEDLINE; Springer Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Aorta, Thoracic - diagnostic imaging Aorta, Thoracic - physiopathology Atherosclerosis - blood Atherosclerosis - complications Atherosclerosis - diagnosis Carotid Intima-Media Thickness Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - etiology Cross-Sectional Studies Electrocardiography Enzyme-Linked Immunosorbent Assay Female Fibroblast Growth Factors - blood Humans Male Medicine Medicine & Public Health Middle Aged Nephrology Nephrology - Original Paper Renal Dialysis Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - therapy Tomography, X-Ray Computed Ultrasonography, Doppler, Color Urology Vascular Calcification - blood Vascular Calcification - diagnosis Vascular Calcification - etiology Young Adult |
| title | FGF-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients |
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