The Chihuahua dog: A new animal model for neuronal ceroid lipofuscinosis CLN7 disease?

Neuronal ceroid lipofuscinoses (NCLs) are a group of incurable lysosomal storage disorders characterized by neurodegeneration and accumulation of lipopigments mainly within the neurons. We studied two littermate Chihuahua dogs presenting with progressive signs of blindness, ataxia, pacing, and cogni...

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Veröffentlicht in:	Journal of neuroscience research 2016-04, Vol.94 (4), p.339-347
Hauptverfasser:	Faller, Kiterie M.E., Bras, Jose, Sharpe, Samuel J., Anderson, Glenn W., Darwent, Lee, Kun-Rodrigues, Celia, Alroy, Joseph, Penderis, Jacques, Mole, Sara E., Gutierrez-Quintana, Rodrigo, Guerreiro, Rita J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Dogs Female lysosomal storage disorder Male Membrane Transport Proteins - genetics MFSD8 neurodegeneration Neuronal Ceroid-Lipofuscinoses - genetics Neuronal Ceroid-Lipofuscinoses - pathology Neuronal Ceroid-Lipofuscinoses - veterinary Polymerase Chain Reaction
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