The Evaluation of Abnormal Voice Qualities in Patients with Amyotrophic Lateral Sclerosis
Objective: Voice abnormalities are among the symptoms occurring in patients with amyotrophic lateral sclerosis (ALS). They are divergent and range from hoarseness, through the excessive adduction of false folds, up to the weakness of the vocal folds. The aim of the study was to analyze the phonatory...
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| Veröffentlicht in: | Neuro-degenerative diseases 2015-07, Vol.15 (4), p.225-232 |
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| creator | Tomik, Jerzy Tomik, Barbara Wiatr, Maciej Składzień, Jacek Stręk, Paweł Szczudlik, Andrzej |
| description | Objective: Voice abnormalities are among the symptoms occurring in patients with amyotrophic lateral sclerosis (ALS). They are divergent and range from hoarseness, through the excessive adduction of false folds, up to the weakness of the vocal folds. The aim of the study was to analyze the phonatory function of the larynx in ALS patients. Methods: Seventeen patients with ALS were evaluated with subjective perceptual voice assessment (including the GRBAS scale), videolaryngostroboscopy including voice range and maximum phonation time (MPT), and objective acoustic voice analysis with IRIS software (including evaluation of jitter, shimmer, mean fundamental frequency, and noise-to-harmonics ratio (NHR)). Examinations were performed three times at 6-month intervals. Results: Hoarseness, roughness, and breathiness of voice were all found more frequently in the majority of these patients. Voice range, amplitude of vibration, mucosal wave, and glottal closure showed significant abnormalities with repeated examinations. MPT was shortened especially among women with ALS. Acoustic analysis of voice among men showed increased jitter value in the first examination only, while jitter, shimmer, and NHR in women with ALS were increased in all examinations. Conclusions: Analysis of voice qualities among patients with ALS allows for the detection of various abnormalities associated with the natural progression of the disease. |
| doi_str_mv | 10.1159/000381956 |
| format | Article |
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They are divergent and range from hoarseness, through the excessive adduction of false folds, up to the weakness of the vocal folds. The aim of the study was to analyze the phonatory function of the larynx in ALS patients. Methods: Seventeen patients with ALS were evaluated with subjective perceptual voice assessment (including the GRBAS scale), videolaryngostroboscopy including voice range and maximum phonation time (MPT), and objective acoustic voice analysis with IRIS software (including evaluation of jitter, shimmer, mean fundamental frequency, and noise-to-harmonics ratio (NHR)). Examinations were performed three times at 6-month intervals. Results: Hoarseness, roughness, and breathiness of voice were all found more frequently in the majority of these patients. Voice range, amplitude of vibration, mucosal wave, and glottal closure showed significant abnormalities with repeated examinations. MPT was shortened especially among women with ALS. Acoustic analysis of voice among men showed increased jitter value in the first examination only, while jitter, shimmer, and NHR in women with ALS were increased in all examinations. Conclusions: Analysis of voice qualities among patients with ALS allows for the detection of various abnormalities associated with the natural progression of the disease.</description><identifier>ISSN: 1660-2854</identifier><identifier>EISSN: 1660-2862</identifier><identifier>DOI: 10.1159/000381956</identifier><identifier>PMID: 25967115</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - complications ; Amyotrophic Lateral Sclerosis - physiopathology ; Care and treatment ; Complications and side effects ; Development and progression ; Female ; Hoarseness - complications ; Humans ; Laryngeal diseases ; Larynx - physiopathology ; Male ; Middle Aged ; Original Paper ; Phonation - drug effects ; Voice Quality - physiology</subject><ispartof>Neuro-degenerative diseases, 2015-07, Vol.15 (4), p.225-232</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>2015 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2015 S. Karger AG</rights><rights>Copyright (c) 2015 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-5fe3a0beb2a73f6667a7370214dbb34c674840218b76f9e4049d7a9ea384cb223</citedby><cites>FETCH-LOGICAL-c431t-5fe3a0beb2a73f6667a7370214dbb34c674840218b76f9e4049d7a9ea384cb223</cites><orcidid>0000-0003-2440-6497</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25967115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomik, Jerzy</creatorcontrib><creatorcontrib>Tomik, Barbara</creatorcontrib><creatorcontrib>Wiatr, Maciej</creatorcontrib><creatorcontrib>Składzień, Jacek</creatorcontrib><creatorcontrib>Stręk, Paweł</creatorcontrib><creatorcontrib>Szczudlik, Andrzej</creatorcontrib><title>The Evaluation of Abnormal Voice Qualities in Patients with Amyotrophic Lateral Sclerosis</title><title>Neuro-degenerative diseases</title><addtitle>Neurodegener Dis</addtitle><description>Objective: Voice abnormalities are among the symptoms occurring in patients with amyotrophic lateral sclerosis (ALS). They are divergent and range from hoarseness, through the excessive adduction of false folds, up to the weakness of the vocal folds. The aim of the study was to analyze the phonatory function of the larynx in ALS patients. Methods: Seventeen patients with ALS were evaluated with subjective perceptual voice assessment (including the GRBAS scale), videolaryngostroboscopy including voice range and maximum phonation time (MPT), and objective acoustic voice analysis with IRIS software (including evaluation of jitter, shimmer, mean fundamental frequency, and noise-to-harmonics ratio (NHR)). Examinations were performed three times at 6-month intervals. Results: Hoarseness, roughness, and breathiness of voice were all found more frequently in the majority of these patients. Voice range, amplitude of vibration, mucosal wave, and glottal closure showed significant abnormalities with repeated examinations. MPT was shortened especially among women with ALS. Acoustic analysis of voice among men showed increased jitter value in the first examination only, while jitter, shimmer, and NHR in women with ALS were increased in all examinations. Conclusions: Analysis of voice qualities among patients with ALS allows for the detection of various abnormalities associated with the natural progression of the disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - complications</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Female</subject><subject>Hoarseness - complications</subject><subject>Humans</subject><subject>Laryngeal diseases</subject><subject>Larynx - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Phonation - drug effects</subject><subject>Voice Quality - physiology</subject><issn>1660-2854</issn><issn>1660-2862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0c9LHDEUB_AgFbXWg_dSAkKph23za_LjuIhaYaEttYKnITP7xonNTNYkY_G_b5Zd99BTTy-Bz0t434fQKSWfKa3MF0II19RUcg8dUSnJjGnJ3uzOlThEb1N6JIQZZegBOmSVkaq0HqH72x7w5bP1k80ujDh0eN6MIQ7W47vgWsA_JutddpCwG_H3omDMCf9xucfz4SXkGFa9a_HCZoil6WfrIYbk0ju031mf4GRbj9Gvq8vbi6-zxbfrm4v5YtYKTvOs6oBb0kDDrOKdlFKVqgijYtk0XLRSCS3KVTdKdgYEEWaprAHLtWgbxvgx-rR5dxXD0wQp14NLLXhvRwhTqqnSpCpJaPUflFAuhNG80LN_6GOY4lgGWasSL-WqKurjRj1YD3UP1uc-BT-to0z1XHLFKWVaF3i-gW3JJkXo6lV0g40vNSX1eof1bofFfth-PTUDLHfydWkFvN-A3zY-QNyBbf9ffRucnA</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Tomik, Jerzy</creator><creator>Tomik, Barbara</creator><creator>Wiatr, Maciej</creator><creator>Składzień, Jacek</creator><creator>Stręk, Paweł</creator><creator>Szczudlik, Andrzej</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2440-6497</orcidid></search><sort><creationdate>20150701</creationdate><title>The Evaluation of Abnormal Voice Qualities in Patients with Amyotrophic Lateral Sclerosis</title><author>Tomik, Jerzy ; Tomik, Barbara ; Wiatr, Maciej ; Składzień, Jacek ; Stręk, Paweł ; Szczudlik, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-5fe3a0beb2a73f6667a7370214dbb34c674840218b76f9e4049d7a9ea384cb223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - complications</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Female</topic><topic>Hoarseness - complications</topic><topic>Humans</topic><topic>Laryngeal diseases</topic><topic>Larynx - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Phonation - drug effects</topic><topic>Voice Quality - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomik, Jerzy</creatorcontrib><creatorcontrib>Tomik, Barbara</creatorcontrib><creatorcontrib>Wiatr, Maciej</creatorcontrib><creatorcontrib>Składzień, Jacek</creatorcontrib><creatorcontrib>Stręk, Paweł</creatorcontrib><creatorcontrib>Szczudlik, Andrzej</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuro-degenerative diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomik, Jerzy</au><au>Tomik, Barbara</au><au>Wiatr, Maciej</au><au>Składzień, Jacek</au><au>Stręk, Paweł</au><au>Szczudlik, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Evaluation of Abnormal Voice Qualities in Patients with Amyotrophic Lateral Sclerosis</atitle><jtitle>Neuro-degenerative diseases</jtitle><addtitle>Neurodegener Dis</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>15</volume><issue>4</issue><spage>225</spage><epage>232</epage><pages>225-232</pages><issn>1660-2854</issn><eissn>1660-2862</eissn><abstract>Objective: Voice abnormalities are among the symptoms occurring in patients with amyotrophic lateral sclerosis (ALS). They are divergent and range from hoarseness, through the excessive adduction of false folds, up to the weakness of the vocal folds. The aim of the study was to analyze the phonatory function of the larynx in ALS patients. Methods: Seventeen patients with ALS were evaluated with subjective perceptual voice assessment (including the GRBAS scale), videolaryngostroboscopy including voice range and maximum phonation time (MPT), and objective acoustic voice analysis with IRIS software (including evaluation of jitter, shimmer, mean fundamental frequency, and noise-to-harmonics ratio (NHR)). Examinations were performed three times at 6-month intervals. Results: Hoarseness, roughness, and breathiness of voice were all found more frequently in the majority of these patients. Voice range, amplitude of vibration, mucosal wave, and glottal closure showed significant abnormalities with repeated examinations. MPT was shortened especially among women with ALS. Acoustic analysis of voice among men showed increased jitter value in the first examination only, while jitter, shimmer, and NHR in women with ALS were increased in all examinations. Conclusions: Analysis of voice qualities among patients with ALS allows for the detection of various abnormalities associated with the natural progression of the disease.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>25967115</pmid><doi>10.1159/000381956</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2440-6497</orcidid></addata></record> |
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| ispartof | Neuro-degenerative diseases, 2015-07, Vol.15 (4), p.225-232 |
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| subjects | Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - complications Amyotrophic Lateral Sclerosis - physiopathology Care and treatment Complications and side effects Development and progression Female Hoarseness - complications Humans Laryngeal diseases Larynx - physiopathology Male Middle Aged Original Paper Phonation - drug effects Voice Quality - physiology |
| title | The Evaluation of Abnormal Voice Qualities in Patients with Amyotrophic Lateral Sclerosis |
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