Study of Subchronic Toxicity of Relatox on Sexually Immature Animals
Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2015-11, Vol.160 (1), p.53-56 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Churin, A. A. Fomina, T. I. Ermolaeva, L. A. Vetoshkina, T. V. Dubskaya, T. Yu Lamzina, T. Yu Fedorova, E. P. Neupokoeva, O. V. Nikiforova, A. N. |
| description | Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal. |
| doi_str_mv | 10.1007/s10517-015-3096-1 |
| format | Article |
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A. ; Fomina, T. I. ; Ermolaeva, L. A. ; Vetoshkina, T. V. ; Dubskaya, T. Yu ; Lamzina, T. Yu ; Fedorova, E. P. ; Neupokoeva, O. V. ; Nikiforova, A. N.</creator><creatorcontrib>Churin, A. A. ; Fomina, T. I. ; Ermolaeva, L. A. ; Vetoshkina, T. V. ; Dubskaya, T. Yu ; Lamzina, T. Yu ; Fedorova, E. P. ; Neupokoeva, O. V. ; Nikiforova, A. N.</creatorcontrib><description>Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-015-3096-1</identifier><identifier>PMID: 26593416</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Animals, Outbred Strains ; Atrophy ; Biomedical and Life Sciences ; Biomedicine ; Botulinum Toxins, Type A - pharmacology ; Botulinum Toxins, Type A - toxicity ; Cell Biology ; Drug Combinations ; Edema - chemically induced ; Edema - pathology ; Exploratory Behavior - drug effects ; Female ; Hemagglutinins - pharmacology ; Hemagglutinins - toxicity ; Hindlimb ; Injections, Intramuscular ; Internal Medicine ; Laboratory Medicine ; Locomotion - drug effects ; Male ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiology ; Myofibrils - drug effects ; Myofibrils - pathology ; Organ Size - drug effects ; Paresis - chemically induced ; Paresis - pathology ; Pathology ; Rats ; Regeneration ; Sexual Maturation ; Viscera - drug effects ; Weight Loss - drug effects</subject><ispartof>Bulletin of experimental biology and medicine, 2015-11, Vol.160 (1), p.53-56</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>COPYRIGHT 2015 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-015-3096-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-015-3096-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26593416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Churin, A. A.</creatorcontrib><creatorcontrib>Fomina, T. I.</creatorcontrib><creatorcontrib>Ermolaeva, L. A.</creatorcontrib><creatorcontrib>Vetoshkina, T. V.</creatorcontrib><creatorcontrib>Dubskaya, T. Yu</creatorcontrib><creatorcontrib>Lamzina, T. Yu</creatorcontrib><creatorcontrib>Fedorova, E. P.</creatorcontrib><creatorcontrib>Neupokoeva, O. V.</creatorcontrib><creatorcontrib>Nikiforova, A. N.</creatorcontrib><title>Study of Subchronic Toxicity of Relatox on Sexually Immature Animals</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal.</description><subject>Animals</subject><subject>Animals, Outbred Strains</subject><subject>Atrophy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Botulinum Toxins, Type A - pharmacology</subject><subject>Botulinum Toxins, Type A - toxicity</subject><subject>Cell Biology</subject><subject>Drug Combinations</subject><subject>Edema - chemically induced</subject><subject>Edema - pathology</subject><subject>Exploratory Behavior - drug effects</subject><subject>Female</subject><subject>Hemagglutinins - pharmacology</subject><subject>Hemagglutinins - toxicity</subject><subject>Hindlimb</subject><subject>Injections, Intramuscular</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Locomotion - drug effects</subject><subject>Male</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiology</subject><subject>Myofibrils - drug effects</subject><subject>Myofibrils - pathology</subject><subject>Organ Size - drug effects</subject><subject>Paresis - chemically induced</subject><subject>Paresis - pathology</subject><subject>Pathology</subject><subject>Rats</subject><subject>Regeneration</subject><subject>Sexual Maturation</subject><subject>Viscera - drug effects</subject><subject>Weight Loss - drug effects</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkl9rFDEUxYModq1-AF9kQJC-TM1NJpPM49JaLRQEtz6HJJN0p8xMav7A7rc341ZtRUHycMnN7xy4Nweh14BPAWP-PgJmwGsMrKa4a2t4glbAOK0FIfAUrXCB6kYIcYRexHi7XHELz9ERaVlHG2hX6HyTcr-vvKs2WZtt8PNgqmu_G8yQfrS_2FElv6v8XG3sLqtx3FeX06RSDrZaz8OkxvgSPXOl2Ff39Rh9vfhwffapvvr88fJsfVUbRliqtTaC6141GjslLJCeOOYsCN1oInoHHXEa97yzhnBLNMGMQt8ZbXjpUaDH6OTgexf8t2xjktMQjR1HNVufowQuykLalvwP2rSCEwykoG__QG99DnMZpFCcEkaxaH5TN2q0cpidT0GZxVSum6ZhHWspK9TpX6hyejsNxs_WDaX_SPDugWBr1Zi20Y85DX6Oj0E4gCb4GIN18i6U5Ye9BCyXNMhDGmRJg1zSIJclvLmfLOvJ9r8UP7-_AOQAxPI039jwYPR_un4HYCK7zw</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Churin, A. A.</creator><creator>Fomina, T. I.</creator><creator>Ermolaeva, L. A.</creator><creator>Vetoshkina, T. V.</creator><creator>Dubskaya, T. Yu</creator><creator>Lamzina, T. Yu</creator><creator>Fedorova, E. P.</creator><creator>Neupokoeva, O. V.</creator><creator>Nikiforova, A. 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A. ; Fomina, T. I. ; Ermolaeva, L. A. ; Vetoshkina, T. V. ; Dubskaya, T. Yu ; Lamzina, T. Yu ; Fedorova, E. P. ; Neupokoeva, O. V. ; Nikiforova, A. 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A.</au><au>Fomina, T. I.</au><au>Ermolaeva, L. A.</au><au>Vetoshkina, T. V.</au><au>Dubskaya, T. Yu</au><au>Lamzina, T. Yu</au><au>Fedorova, E. P.</au><au>Neupokoeva, O. V.</au><au>Nikiforova, A. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of Subchronic Toxicity of Relatox on Sexually Immature Animals</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>160</volume><issue>1</issue><spage>53</spage><epage>56</epage><pages>53-56</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26593416</pmid><doi>10.1007/s10517-015-3096-1</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Animals, Outbred Strains Atrophy Biomedical and Life Sciences Biomedicine Botulinum Toxins, Type A - pharmacology Botulinum Toxins, Type A - toxicity Cell Biology Drug Combinations Edema - chemically induced Edema - pathology Exploratory Behavior - drug effects Female Hemagglutinins - pharmacology Hemagglutinins - toxicity Hindlimb Injections, Intramuscular Internal Medicine Laboratory Medicine Locomotion - drug effects Male Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscle, Skeletal - physiology Myofibrils - drug effects Myofibrils - pathology Organ Size - drug effects Paresis - chemically induced Paresis - pathology Pathology Rats Regeneration Sexual Maturation Viscera - drug effects Weight Loss - drug effects |
| title | Study of Subchronic Toxicity of Relatox on Sexually Immature Animals |
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