Study of Subchronic Toxicity of Relatox on Sexually Immature Animals

Study of Subchronic Toxicity of Relatox on Sexually Immature Animals

Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2015-11, Vol.160 (1), p.53-56
Hauptverfasser: Churin, A. A., Fomina, T. I., Ermolaeva, L. A., Vetoshkina, T. V., Dubskaya, T. Yu, Lamzina, T. Yu, Fedorova, E. P., Neupokoeva, O. V., Nikiforova, A. N.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Animals, Outbred Strains
Atrophy
Biomedical and Life Sciences
Biomedicine
Botulinum Toxins, Type A - pharmacology
Botulinum Toxins, Type A - toxicity
Cell Biology
Drug Combinations
Edema - chemically induced
Edema - pathology
Exploratory Behavior - drug effects
Female
Hemagglutinins - pharmacology
Hemagglutinins - toxicity
Hindlimb
Injections, Intramuscular
Internal Medicine
Laboratory Medicine
Locomotion - drug effects
Male
Muscle, Skeletal - drug effects
Muscle, Skeletal - pathology
Muscle, Skeletal - physiology
Myofibrils - drug effects
Myofibrils - pathology
Organ Size - drug effects
Paresis - chemically induced
Paresis - pathology
Pathology
Rats
Regeneration
Sexual Maturation
Viscera - drug effects
Weight Loss - drug effects
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Beschreibung
Zusammenfassung:Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-3096-1