KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis

Kisspeptin (KP) is now well recognized as a potent stimulator of gonadotropin-releasing hormone (GnRH) secretion and thereby a major regulator of the neuroendocrine-reproductive axis. KP signals via KISS1R, a G protein-coupled receptor (GPCR) that activates the G proteins Gα q/11 . Modulation of the...

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Veröffentlicht in:	Neuroendocrinology 2015-06, Vol.101 (3), p.193-210
Hauptverfasser:	Millar, Robert P., Babwah, Andy V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrestins - metabolism At the Cutting Edge beta-Arrestins Cellular signal transduction Female Gonadotropin releasing hormone Gonadotropin-Releasing Hormone - secretion GTP-Binding Protein alpha Subunits - metabolism Health aspects Humans Kisspeptins - metabolism Male Neurons - metabolism Neurons - secretion Neuropeptides Neurosecretory Systems - metabolism Physiological aspects Proteolysis Receptors, G-Protein-Coupled - metabolism Receptors, Kisspeptin-1 Reproduction Signal Transduction
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