The use of a polylactide-based copolymer as a temporary skin substitute in deep dermal burns: 1-year follow-up results of a prospective clinical noninferiority trial
Deep dermal burns can be covered with different kind of materials and techniques; one of them is a polylactide‐based temporary skin substitute. The aim of this study was to intraindividually compare its 1‐year outcome with the results obtained by use of autologous skin grafts in patients suffering f...
Gespeichert in:
Veröffentlicht in: | Wound repair and regeneration 2013-05, Vol.21 (3), p.402-409 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 409 |
---|---|
container_issue | 3 |
container_start_page | 402 |
container_title | Wound repair and regeneration |
container_volume | 21 |
creator | Selig, Harald F. Keck, Maike Lumenta, David B. Mittlböck, Martina Kamolz, Lars P. |
description | Deep dermal burns can be covered with different kind of materials and techniques; one of them is a polylactide‐based temporary skin substitute. The aim of this study was to intraindividually compare its 1‐year outcome with the results obtained by use of autologous skin grafts in patients suffering from deep dermal burns. A prospective noninferiority trial was designed in order to assess skin quality and scar formation by use of subjective (Vancouver Scar Scale; Patient and Observer Scar Assessment Scale) and objective (noninvasive cutometry) burn scar assessment tools. All items of the Patient and Observer Scar Assessment Scale, except vascularity, were found to be noninferior in the areas covered with the temporary skin substitute vs. autologous skin. Results of objective scar evaluation showed comparable viscoelastic parameters without reaching noninferiority. Overall, the outcome of deep dermal burns covered with a polylactide‐based temporary skin substitute revealed satisfactory results in terms of scar formation and skin quality as compared with autologous skin. This paper supports its use in deep dermal burns, where autologous skin donor sites require either to be reserved for coverage of full‐thickness skin defects in severe burns or to be saved for reduction of additional morbidity in selected patient collectives. |
doi_str_mv | 10.1111/wrr.12050 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1780516529</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1780516529</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3960-969889a159310e622349ab67837c42e61e0ef7c2aa932b8b88373e044e5a957b3</originalsourceid><addsrcrecordid>eNqFkctu1DAYhSMEoqWw4AWQl7Bw60tsx-zQiLZIFZdR0bCznMwfYerEwXYY8kB9T1xm2h3CC1-_c37bp6peUnJKSzvbxXhKGRHkUXVMBatxrcS3x2VOpMJUM3VUPUvpByFECN08rY4Yl0xJxY6r2-vvgOYEKPTIoin4xdsuuy3g1ibYoi7c7Q0QkU0FyDBMIdq4oHTjRpTmNmWX5wyorLYAU-niYD1q5zimt4jiBWxEffA-7PA8oQhp9jkdysWQJijlfgHqvBtdV5RjGN3YQ3QhurygHJ31z6snvfUJXhzGk-rr-fvr1SW--nTxYfXuCndcS4K11E2jLRWaUwKSMV5r20rVcNXVDCQFAr3qmLWas7Zpm3LAgdQ1CKuFavlJ9XrvW272c4aUzeBSB97bEcKcDFUNEVQKpv-Pltpca6VEQd_s0a68N0XozRTdUD7RUGLuAjQlQPM3wMK-OtjO7QDbB_I-sQKc7YGd87D828ls1ut7S7xXuJTh94PCxhsjFVfCbD5emM-btfoixLlZ8T-8jbYy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1349399775</pqid></control><display><type>article</type><title>The use of a polylactide-based copolymer as a temporary skin substitute in deep dermal burns: 1-year follow-up results of a prospective clinical noninferiority trial</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Selig, Harald F. ; Keck, Maike ; Lumenta, David B. ; Mittlböck, Martina ; Kamolz, Lars P.</creator><creatorcontrib>Selig, Harald F. ; Keck, Maike ; Lumenta, David B. ; Mittlböck, Martina ; Kamolz, Lars P.</creatorcontrib><description>Deep dermal burns can be covered with different kind of materials and techniques; one of them is a polylactide‐based temporary skin substitute. The aim of this study was to intraindividually compare its 1‐year outcome with the results obtained by use of autologous skin grafts in patients suffering from deep dermal burns. A prospective noninferiority trial was designed in order to assess skin quality and scar formation by use of subjective (Vancouver Scar Scale; Patient and Observer Scar Assessment Scale) and objective (noninvasive cutometry) burn scar assessment tools. All items of the Patient and Observer Scar Assessment Scale, except vascularity, were found to be noninferior in the areas covered with the temporary skin substitute vs. autologous skin. Results of objective scar evaluation showed comparable viscoelastic parameters without reaching noninferiority. Overall, the outcome of deep dermal burns covered with a polylactide‐based temporary skin substitute revealed satisfactory results in terms of scar formation and skin quality as compared with autologous skin. This paper supports its use in deep dermal burns, where autologous skin donor sites require either to be reserved for coverage of full‐thickness skin defects in severe burns or to be saved for reduction of additional morbidity in selected patient collectives.</description><identifier>ISSN: 1067-1927</identifier><identifier>EISSN: 1524-475X</identifier><identifier>DOI: 10.1111/wrr.12050</identifier><identifier>PMID: 23627672</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Absorbable Implants ; Adult ; Burns - pathology ; Burns - surgery ; Cicatrix - pathology ; Cicatrix - prevention & control ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Polyesters ; Prospective Studies ; Reconstructive Surgical Procedures ; Skin - injuries ; Skin - pathology ; Skin Transplantation - methods ; Skin, Artificial ; Time Factors ; Treatment Outcome ; Wound Healing - physiology</subject><ispartof>Wound repair and regeneration, 2013-05, Vol.21 (3), p.402-409</ispartof><rights>2013 by the Wound Healing Society</rights><rights>2013 by the Wound Healing Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3960-969889a159310e622349ab67837c42e61e0ef7c2aa932b8b88373e044e5a957b3</citedby><cites>FETCH-LOGICAL-c3960-969889a159310e622349ab67837c42e61e0ef7c2aa932b8b88373e044e5a957b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fwrr.12050$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fwrr.12050$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23627672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Selig, Harald F.</creatorcontrib><creatorcontrib>Keck, Maike</creatorcontrib><creatorcontrib>Lumenta, David B.</creatorcontrib><creatorcontrib>Mittlböck, Martina</creatorcontrib><creatorcontrib>Kamolz, Lars P.</creatorcontrib><title>The use of a polylactide-based copolymer as a temporary skin substitute in deep dermal burns: 1-year follow-up results of a prospective clinical noninferiority trial</title><title>Wound repair and regeneration</title><addtitle>Wound Repair Regen</addtitle><description>Deep dermal burns can be covered with different kind of materials and techniques; one of them is a polylactide‐based temporary skin substitute. The aim of this study was to intraindividually compare its 1‐year outcome with the results obtained by use of autologous skin grafts in patients suffering from deep dermal burns. A prospective noninferiority trial was designed in order to assess skin quality and scar formation by use of subjective (Vancouver Scar Scale; Patient and Observer Scar Assessment Scale) and objective (noninvasive cutometry) burn scar assessment tools. All items of the Patient and Observer Scar Assessment Scale, except vascularity, were found to be noninferior in the areas covered with the temporary skin substitute vs. autologous skin. Results of objective scar evaluation showed comparable viscoelastic parameters without reaching noninferiority. Overall, the outcome of deep dermal burns covered with a polylactide‐based temporary skin substitute revealed satisfactory results in terms of scar formation and skin quality as compared with autologous skin. This paper supports its use in deep dermal burns, where autologous skin donor sites require either to be reserved for coverage of full‐thickness skin defects in severe burns or to be saved for reduction of additional morbidity in selected patient collectives.</description><subject>Absorbable Implants</subject><subject>Adult</subject><subject>Burns - pathology</subject><subject>Burns - surgery</subject><subject>Cicatrix - pathology</subject><subject>Cicatrix - prevention & control</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polyesters</subject><subject>Prospective Studies</subject><subject>Reconstructive Surgical Procedures</subject><subject>Skin - injuries</subject><subject>Skin - pathology</subject><subject>Skin Transplantation - methods</subject><subject>Skin, Artificial</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Wound Healing - physiology</subject><issn>1067-1927</issn><issn>1524-475X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAYhSMEoqWw4AWQl7Bw60tsx-zQiLZIFZdR0bCznMwfYerEwXYY8kB9T1xm2h3CC1-_c37bp6peUnJKSzvbxXhKGRHkUXVMBatxrcS3x2VOpMJUM3VUPUvpByFECN08rY4Yl0xJxY6r2-vvgOYEKPTIoin4xdsuuy3g1ibYoi7c7Q0QkU0FyDBMIdq4oHTjRpTmNmWX5wyorLYAU-niYD1q5zimt4jiBWxEffA-7PA8oQhp9jkdysWQJijlfgHqvBtdV5RjGN3YQ3QhurygHJ31z6snvfUJXhzGk-rr-fvr1SW--nTxYfXuCndcS4K11E2jLRWaUwKSMV5r20rVcNXVDCQFAr3qmLWas7Zpm3LAgdQ1CKuFavlJ9XrvW272c4aUzeBSB97bEcKcDFUNEVQKpv-Pltpca6VEQd_s0a68N0XozRTdUD7RUGLuAjQlQPM3wMK-OtjO7QDbB_I-sQKc7YGd87D828ls1ut7S7xXuJTh94PCxhsjFVfCbD5emM-btfoixLlZ8T-8jbYy</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Selig, Harald F.</creator><creator>Keck, Maike</creator><creator>Lumenta, David B.</creator><creator>Mittlböck, Martina</creator><creator>Kamolz, Lars P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201305</creationdate><title>The use of a polylactide-based copolymer as a temporary skin substitute in deep dermal burns: 1-year follow-up results of a prospective clinical noninferiority trial</title><author>Selig, Harald F. ; Keck, Maike ; Lumenta, David B. ; Mittlböck, Martina ; Kamolz, Lars P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3960-969889a159310e622349ab67837c42e61e0ef7c2aa932b8b88373e044e5a957b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Absorbable Implants</topic><topic>Adult</topic><topic>Burns - pathology</topic><topic>Burns - surgery</topic><topic>Cicatrix - pathology</topic><topic>Cicatrix - prevention & control</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polyesters</topic><topic>Prospective Studies</topic><topic>Reconstructive Surgical Procedures</topic><topic>Skin - injuries</topic><topic>Skin - pathology</topic><topic>Skin Transplantation - methods</topic><topic>Skin, Artificial</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selig, Harald F.</creatorcontrib><creatorcontrib>Keck, Maike</creatorcontrib><creatorcontrib>Lumenta, David B.</creatorcontrib><creatorcontrib>Mittlböck, Martina</creatorcontrib><creatorcontrib>Kamolz, Lars P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Wound repair and regeneration</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Selig, Harald F.</au><au>Keck, Maike</au><au>Lumenta, David B.</au><au>Mittlböck, Martina</au><au>Kamolz, Lars P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of a polylactide-based copolymer as a temporary skin substitute in deep dermal burns: 1-year follow-up results of a prospective clinical noninferiority trial</atitle><jtitle>Wound repair and regeneration</jtitle><addtitle>Wound Repair Regen</addtitle><date>2013-05</date><risdate>2013</risdate><volume>21</volume><issue>3</issue><spage>402</spage><epage>409</epage><pages>402-409</pages><issn>1067-1927</issn><eissn>1524-475X</eissn><abstract>Deep dermal burns can be covered with different kind of materials and techniques; one of them is a polylactide‐based temporary skin substitute. The aim of this study was to intraindividually compare its 1‐year outcome with the results obtained by use of autologous skin grafts in patients suffering from deep dermal burns. A prospective noninferiority trial was designed in order to assess skin quality and scar formation by use of subjective (Vancouver Scar Scale; Patient and Observer Scar Assessment Scale) and objective (noninvasive cutometry) burn scar assessment tools. All items of the Patient and Observer Scar Assessment Scale, except vascularity, were found to be noninferior in the areas covered with the temporary skin substitute vs. autologous skin. Results of objective scar evaluation showed comparable viscoelastic parameters without reaching noninferiority. Overall, the outcome of deep dermal burns covered with a polylactide‐based temporary skin substitute revealed satisfactory results in terms of scar formation and skin quality as compared with autologous skin. This paper supports its use in deep dermal burns, where autologous skin donor sites require either to be reserved for coverage of full‐thickness skin defects in severe burns or to be saved for reduction of additional morbidity in selected patient collectives.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23627672</pmid><doi>10.1111/wrr.12050</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1067-1927 |
ispartof | Wound repair and regeneration, 2013-05, Vol.21 (3), p.402-409 |
issn | 1067-1927 1524-475X |
language | eng |
recordid | cdi_proquest_miscellaneous_1780516529 |
source | MEDLINE; Wiley Journals |
subjects | Absorbable Implants Adult Burns - pathology Burns - surgery Cicatrix - pathology Cicatrix - prevention & control Female Follow-Up Studies Humans Male Middle Aged Polyesters Prospective Studies Reconstructive Surgical Procedures Skin - injuries Skin - pathology Skin Transplantation - methods Skin, Artificial Time Factors Treatment Outcome Wound Healing - physiology |
title | The use of a polylactide-based copolymer as a temporary skin substitute in deep dermal burns: 1-year follow-up results of a prospective clinical noninferiority trial |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A07%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20use%20of%20a%20polylactide-based%20copolymer%20as%20a%20temporary%20skin%20substitute%20in%20deep%20dermal%20burns:%201-year%20follow-up%20results%20of%20a%20prospective%20clinical%20noninferiority%20trial&rft.jtitle=Wound%20repair%20and%20regeneration&rft.au=Selig,%20Harald%20F.&rft.date=2013-05&rft.volume=21&rft.issue=3&rft.spage=402&rft.epage=409&rft.pages=402-409&rft.issn=1067-1927&rft.eissn=1524-475X&rft_id=info:doi/10.1111/wrr.12050&rft_dat=%3Cproquest_cross%3E1780516529%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1349399775&rft_id=info:pmid/23627672&rfr_iscdi=true |