Prognostic value of BRAF and KRAS mutation status in stage II and III microsatellite instable colon cancers

Microsatellite instability (MSI) has been associated with favourable survival in early stage colorectal cancer (CRC) compared to microsatellite stable (MSS) CRC. The BRAF V600E mutation has been associated with worse survival in MSS CRC. This mutation occurs in 40% of MSI CRC and it is unclear wheth...

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Veröffentlicht in:	International journal of cancer 2016-03, Vol.138 (5), p.1139-1145
Hauptverfasser:	de Cuba, E.M.V., Snaebjornsson, P., Heideman, D.A.M., van Grieken, N.C.T., Bosch, L.J.W., Fijneman, R.J.A., Belt, E., Bril, H., Stockmann, H.B.A.C., Hooijberg, E., Punt, C.J.A., Koopman, M., Nagtegaal, I.D., Coupé, V.H.M., Carvalho, B., Meijer, G.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over BRAF Cancer Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma DNA repair Female High resolution Humans K-Ras protein KRAS Male Medical research Microsatellite Instability Middle Aged Mismatch repair Multivariate analysis Mutation Neoplasm Staging Prognosis Proportional Hazards Models Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Regression analysis Survival Tumors
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