Bile acids trigger cholemic nephropathy in common bile‐duct–ligated mice

Tubular epithelial injury represents an underestimated but important cause of renal dysfunction in patients with cholestasis and advanced liver disease, but the underlying mechanisms are unclear. To address the hypothesis that accumulation and excessive alternative urinary elimination of potentially...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2013-12, Vol.58 (6), p.2056-2069
Hauptverfasser:	Fickert, Peter, Krones, Elisabeth, Pollheimer, Marion J., Thueringer, Andrea, Moustafa, Tarek, Silbert, Dagmar, Halilbasic, Emina, Yang, Min, Jaeschke, Hartmut, Stokman, Geurt, Wells, Rebecca G., Eller, Kathrin, Rosenkranz, Alexander R., Eggertsen, Gosta, Wagner, Carsten A., Langner, Cord, Denk, Helmut, Trauner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Bile Bile Acids and Salts - adverse effects Cholestasis - complications Common Bile Duct Disease Models, Animal Gallbladder diseases Hepatology Kidney Diseases - chemically induced Kidney Tubules - injuries Ligation Male Mice Mice, Inbred C57BL Mice, Knockout Nephritis, Interstitial - etiology Receptors, Cytoplasmic and Nuclear - genetics Rodents Ursodeoxycholic Acid - analogs & derivatives Ursodeoxycholic Acid - therapeutic use
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