Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers

The main aim of this study was to discover small molecule inhibitors against Cathepsin D (CatD) (EC.3.4.23.5), a clinically proven prognostic marker for breast cancer, and to explore the mechanisms by which CatD could be a useful therapeutic target for triple-positive and triple-negative breast canc...

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Veröffentlicht in:	Molecular diversity 2016-05, Vol.20 (2), p.521-535
Hauptverfasser:	Anantaraju, Hasitha Shilpa, Battu, Madhu Babu, Viswanadha, Srikant, Sriram, Dharmarajan, Yogeeswari, Perumal
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Breast cancer Cathepsin D - antagonists & inhibitors Cathepsin D - chemistry Cathepsin D - genetics Cathepsin D - metabolism Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Crystal structure Drug Screening Assays, Antitumor Gene Expression Regulation, Neoplastic - drug effects Humans Hydrogen-Ion Concentration Life Sciences Lysosomes - drug effects Lysosomes - metabolism Molecular Docking Simulation Molecules Organic Chemistry Original Article Pharmaceutical sciences Pharmacy Polymer Sciences Protease Inhibitors - chemistry Protease Inhibitors - metabolism Protease Inhibitors - pharmacology Protein Conformation Proteins Triple Negative Breast Neoplasms - pathology Tumor Microenvironment - drug effects
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