Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm
ABSTRACT Diabetes is one of the most common human diseases and 15% of the 200 million diabetics worldwide suffer from diabetic wounds. Development of new therapeutic agents is needed for treatment of diabetic wounds. Wound healing is mediated by multiple steps, including inflammation, epithelializat...
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| Veröffentlicht in: | Wound repair and regeneration 2015-07, Vol.23 (4), p.575-582 |
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| container_title | Wound repair and regeneration |
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| creator | Kwon, Yang Woo Heo, Soon Chul Jang, Il Ho Jeong, Geun Ok Yoon, Jung Won Mun, Je-Ho Kim, Jae Ho |
| description | ABSTRACT
Diabetes is one of the most common human diseases and 15% of the 200 million diabetics worldwide suffer from diabetic wounds. Development of new therapeutic agents is needed for treatment of diabetic wounds. Wound healing is mediated by multiple steps, including inflammation, epithelialization, neoangiogenesis, and granulation. Formyl peptide receptor 2 has been known to stimulate angiogenesis, which is essential for tissue repair and cutaneous wound healing. In this study, we explored the therapeutic effects of WKYMVm (Trp‐Lys‐Tyr‐Met‐Val‐D‐Met‐NH2), a synthetic peptide agonist of formyl peptide receptor 2, on cutaneous wounds in streptozotocin‐induced diabetic rats. Topical application of WKYMVm onto cutaneous wounds stimulated formation of von Willebrand factor‐positive capillary and α‐smooth muscle actin‐positive arteriole with a maximal stimulation on day 6, suggesting WKYMVm‐stimulated angiogenesis. Infiltration of immune cells could be detected on early phase during wound healing and WKYMVm treatment acutely augmented infiltration of CD68‐positive macrophages. In addition, reepithelialization and granulation tissue formation were accelerated by treatment with WKYMVm. These results suggest that WKYMVm has therapeutic effects on diabetic wounds by stimulating angiogenesis and infiltration of immune cells. |
| doi_str_mv | 10.1111/wrr.12315 |
| format | Article |
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Diabetes is one of the most common human diseases and 15% of the 200 million diabetics worldwide suffer from diabetic wounds. Development of new therapeutic agents is needed for treatment of diabetic wounds. Wound healing is mediated by multiple steps, including inflammation, epithelialization, neoangiogenesis, and granulation. Formyl peptide receptor 2 has been known to stimulate angiogenesis, which is essential for tissue repair and cutaneous wound healing. In this study, we explored the therapeutic effects of WKYMVm (Trp‐Lys‐Tyr‐Met‐Val‐D‐Met‐NH2), a synthetic peptide agonist of formyl peptide receptor 2, on cutaneous wounds in streptozotocin‐induced diabetic rats. Topical application of WKYMVm onto cutaneous wounds stimulated formation of von Willebrand factor‐positive capillary and α‐smooth muscle actin‐positive arteriole with a maximal stimulation on day 6, suggesting WKYMVm‐stimulated angiogenesis. Infiltration of immune cells could be detected on early phase during wound healing and WKYMVm treatment acutely augmented infiltration of CD68‐positive macrophages. In addition, reepithelialization and granulation tissue formation were accelerated by treatment with WKYMVm. These results suggest that WKYMVm has therapeutic effects on diabetic wounds by stimulating angiogenesis and infiltration of immune cells.</description><identifier>ISSN: 1067-1927</identifier><identifier>EISSN: 1524-475X</identifier><identifier>DOI: 10.1111/wrr.12315</identifier><identifier>PMID: 25973651</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Administration, Topical ; Animals ; Chemotactic Factors ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Male ; Neovascularization, Physiologic - drug effects ; Oligopeptides - administration & dosage ; Rats ; Rats, Sprague-Dawley ; Receptors, Formyl Peptide - agonists ; Skin - blood supply ; Skin - drug effects ; Skin - pathology ; Skin Ulcer - drug therapy ; Skin Ulcer - etiology ; Skin Ulcer - metabolism ; Treatment Outcome ; Wound Healing - drug effects</subject><ispartof>Wound repair and regeneration, 2015-07, Vol.23 (4), p.575-582</ispartof><rights>2015 by the Wound Healing Society</rights><rights>2015 by the Wound Healing Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3965-d0ae1b0bf2d7c8d0bbc1f6ae707c3278d1c5d59e91479e9d8733b41f5c25beed3</citedby><cites>FETCH-LOGICAL-c3965-d0ae1b0bf2d7c8d0bbc1f6ae707c3278d1c5d59e91479e9d8733b41f5c25beed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fwrr.12315$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fwrr.12315$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25973651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Yang Woo</creatorcontrib><creatorcontrib>Heo, Soon Chul</creatorcontrib><creatorcontrib>Jang, Il Ho</creatorcontrib><creatorcontrib>Jeong, Geun Ok</creatorcontrib><creatorcontrib>Yoon, Jung Won</creatorcontrib><creatorcontrib>Mun, Je-Ho</creatorcontrib><creatorcontrib>Kim, Jae Ho</creatorcontrib><title>Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm</title><title>Wound repair and regeneration</title><addtitle>Wound Rep and Reg</addtitle><description>ABSTRACT
Diabetes is one of the most common human diseases and 15% of the 200 million diabetics worldwide suffer from diabetic wounds. Development of new therapeutic agents is needed for treatment of diabetic wounds. Wound healing is mediated by multiple steps, including inflammation, epithelialization, neoangiogenesis, and granulation. Formyl peptide receptor 2 has been known to stimulate angiogenesis, which is essential for tissue repair and cutaneous wound healing. In this study, we explored the therapeutic effects of WKYMVm (Trp‐Lys‐Tyr‐Met‐Val‐D‐Met‐NH2), a synthetic peptide agonist of formyl peptide receptor 2, on cutaneous wounds in streptozotocin‐induced diabetic rats. Topical application of WKYMVm onto cutaneous wounds stimulated formation of von Willebrand factor‐positive capillary and α‐smooth muscle actin‐positive arteriole with a maximal stimulation on day 6, suggesting WKYMVm‐stimulated angiogenesis. Infiltration of immune cells could be detected on early phase during wound healing and WKYMVm treatment acutely augmented infiltration of CD68‐positive macrophages. In addition, reepithelialization and granulation tissue formation were accelerated by treatment with WKYMVm. These results suggest that WKYMVm has therapeutic effects on diabetic wounds by stimulating angiogenesis and infiltration of immune cells.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Chemotactic Factors</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Male</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Oligopeptides - administration & dosage</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Formyl Peptide - agonists</subject><subject>Skin - blood supply</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Skin Ulcer - drug therapy</subject><subject>Skin Ulcer - etiology</subject><subject>Skin Ulcer - metabolism</subject><subject>Treatment Outcome</subject><subject>Wound Healing - drug effects</subject><issn>1067-1927</issn><issn>1524-475X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtv1TAQRi0EoqVlwR9AXsIirce-tuMlVLQg2lIuj8LKcuxJMc2LONHl_ntM03aHxCxmZnHm0-gQ8gzYAeQ63IzjAXAB8gHZBclXxUrLbw_zzpQuwHC9Q56k9JMxJqUpH5MdLo0WSsIu-fhpiu3cuCn2He1r6ufJddjPiW76uQv0B7omdle02lLX0eOLNS_SgD7W0dMBhykGpO6q72Ka6OX772df233yqHZNwqe3c498OX7z-ehtcfrh5N3Rq9PCC6NkEZhDqFhV86B9GVhVeaiVQ820F1yXAbwM0qCBlc49lFqIagW19FxWiEHskRdL7jD2v2ZMk21j8tg0y_8WdMkkgFHsP1BmNDDOIaMvF9SPfUoj1nYYY-vGrQVm_8q2Wba9kZ3Z57exc9ViuCfv7GbgcAE2scHtv5Ps5Xp9F1ksF9kn_r6_cOO1VVroTJ6fWHWuXhulSivFH8JBl28</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Kwon, Yang Woo</creator><creator>Heo, Soon Chul</creator><creator>Jang, Il Ho</creator><creator>Jeong, Geun Ok</creator><creator>Yoon, Jung Won</creator><creator>Mun, Je-Ho</creator><creator>Kim, Jae Ho</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201507</creationdate><title>Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm</title><author>Kwon, Yang Woo ; Heo, Soon Chul ; Jang, Il Ho ; Jeong, Geun Ok ; Yoon, Jung Won ; Mun, Je-Ho ; Kim, Jae Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3965-d0ae1b0bf2d7c8d0bbc1f6ae707c3278d1c5d59e91479e9d8733b41f5c25beed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Chemotactic Factors</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Male</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Oligopeptides - administration & dosage</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Formyl Peptide - agonists</topic><topic>Skin - blood supply</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Skin Ulcer - drug therapy</topic><topic>Skin Ulcer - etiology</topic><topic>Skin Ulcer - metabolism</topic><topic>Treatment Outcome</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, Yang Woo</creatorcontrib><creatorcontrib>Heo, Soon Chul</creatorcontrib><creatorcontrib>Jang, Il Ho</creatorcontrib><creatorcontrib>Jeong, Geun Ok</creatorcontrib><creatorcontrib>Yoon, Jung Won</creatorcontrib><creatorcontrib>Mun, Je-Ho</creatorcontrib><creatorcontrib>Kim, Jae Ho</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Wound repair and regeneration</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, Yang Woo</au><au>Heo, Soon Chul</au><au>Jang, Il Ho</au><au>Jeong, Geun Ok</au><au>Yoon, Jung Won</au><au>Mun, Je-Ho</au><au>Kim, Jae Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm</atitle><jtitle>Wound repair and regeneration</jtitle><addtitle>Wound Rep and Reg</addtitle><date>2015-07</date><risdate>2015</risdate><volume>23</volume><issue>4</issue><spage>575</spage><epage>582</epage><pages>575-582</pages><issn>1067-1927</issn><eissn>1524-475X</eissn><abstract>ABSTRACT
Diabetes is one of the most common human diseases and 15% of the 200 million diabetics worldwide suffer from diabetic wounds. Development of new therapeutic agents is needed for treatment of diabetic wounds. Wound healing is mediated by multiple steps, including inflammation, epithelialization, neoangiogenesis, and granulation. Formyl peptide receptor 2 has been known to stimulate angiogenesis, which is essential for tissue repair and cutaneous wound healing. In this study, we explored the therapeutic effects of WKYMVm (Trp‐Lys‐Tyr‐Met‐Val‐D‐Met‐NH2), a synthetic peptide agonist of formyl peptide receptor 2, on cutaneous wounds in streptozotocin‐induced diabetic rats. Topical application of WKYMVm onto cutaneous wounds stimulated formation of von Willebrand factor‐positive capillary and α‐smooth muscle actin‐positive arteriole with a maximal stimulation on day 6, suggesting WKYMVm‐stimulated angiogenesis. Infiltration of immune cells could be detected on early phase during wound healing and WKYMVm treatment acutely augmented infiltration of CD68‐positive macrophages. In addition, reepithelialization and granulation tissue formation were accelerated by treatment with WKYMVm. These results suggest that WKYMVm has therapeutic effects on diabetic wounds by stimulating angiogenesis and infiltration of immune cells.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25973651</pmid><doi>10.1111/wrr.12315</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Topical Animals Chemotactic Factors Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Male Neovascularization, Physiologic - drug effects Oligopeptides - administration & dosage Rats Rats, Sprague-Dawley Receptors, Formyl Peptide - agonists Skin - blood supply Skin - drug effects Skin - pathology Skin Ulcer - drug therapy Skin Ulcer - etiology Skin Ulcer - metabolism Treatment Outcome Wound Healing - drug effects |
| title | Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm |
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