Peripheral nervous system involvement in chronic spinal cord injury
ABSTRACT Introduction: Upper motor neuron disorders are believed to leave the peripheral nervous system (PNS) intact. In this study we examined whether there is evidence of PNS involvement in spinal cord injury (SCI). Methods: Twelve subjects with chronic low cervical or thoracic SCI were included p...
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| Veröffentlicht in: | Muscle & nerve 2015-12, Vol.52 (6), p.1016-1022 |
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| container_title | Muscle & nerve |
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| creator | Tankisi, Hatice Pugdahl, Kirsten Rasmussen, Mikkel Mylius Clemmensen, Dorte Rawashdeh, Yazan F. Christensen, Peter Krogh, Klaus Fuglsang-Frederiksen, Anders |
| description | ABSTRACT
Introduction: Upper motor neuron disorders are believed to leave the peripheral nervous system (PNS) intact. In this study we examined whether there is evidence of PNS involvement in spinal cord injury (SCI). Methods: Twelve subjects with chronic low cervical or thoracic SCI were included prospectively. Needle electromyography was done in 10 different muscles in each subject bilaterally. Nerve conduction studies (NCS) were conducted in the fibular, tibial, and femoral motor and fibular and sural sensory nerves. Results: Half the subjects had widespread abnormal spontaneous activity (SA), and the amount of SA correlated inversely with reflex activity and nerve length. Fibular nerve entrapment across the knee was seen in 6 subjects, and sciatic nerve entrapment was seen in 1. Apart from entrapment neuropathies, NCS changes were found predominantly in motor nerves. Conclusion: The presence of widespread electrophysiologic changes outside entrapment sites indicates that SCI has a significant impact on the entire PNS, affecting the motor part predominantly. Muscle Nerve 52: 1016–1022, 2015 |
| doi_str_mv | 10.1002/mus.24644 |
| format | Article |
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Introduction: Upper motor neuron disorders are believed to leave the peripheral nervous system (PNS) intact. In this study we examined whether there is evidence of PNS involvement in spinal cord injury (SCI). Methods: Twelve subjects with chronic low cervical or thoracic SCI were included prospectively. Needle electromyography was done in 10 different muscles in each subject bilaterally. Nerve conduction studies (NCS) were conducted in the fibular, tibial, and femoral motor and fibular and sural sensory nerves. Results: Half the subjects had widespread abnormal spontaneous activity (SA), and the amount of SA correlated inversely with reflex activity and nerve length. Fibular nerve entrapment across the knee was seen in 6 subjects, and sciatic nerve entrapment was seen in 1. Apart from entrapment neuropathies, NCS changes were found predominantly in motor nerves. Conclusion: The presence of widespread electrophysiologic changes outside entrapment sites indicates that SCI has a significant impact on the entire PNS, affecting the motor part predominantly. Muscle Nerve 52: 1016–1022, 2015</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.24644</identifier><identifier>PMID: 25758550</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Chronic Disease ; Electromyography ; Evoked Potentials, Somatosensory - physiology ; Female ; Humans ; Male ; Middle Aged ; nerve conduction study ; Neural Conduction - physiology ; peripheral nervous system ; Peripheral Nervous System Diseases - diagnosis ; Peripheral Nervous System Diseases - etiology ; Reaction Time - physiology ; Spinal Cord Injuries - complications ; spinal cord injury ; spontaneous activity ; Statistics, Nonparametric ; Young Adult</subject><ispartof>Muscle & nerve, 2015-12, Vol.52 (6), p.1016-1022</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4664-12dbe8ac7ad2bcfaf2c2c82e58cb546e1ef04342f4699ee5518ca7679725aa5b3</citedby><cites>FETCH-LOGICAL-c4664-12dbe8ac7ad2bcfaf2c2c82e58cb546e1ef04342f4699ee5518ca7679725aa5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.24644$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.24644$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25758550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tankisi, Hatice</creatorcontrib><creatorcontrib>Pugdahl, Kirsten</creatorcontrib><creatorcontrib>Rasmussen, Mikkel Mylius</creatorcontrib><creatorcontrib>Clemmensen, Dorte</creatorcontrib><creatorcontrib>Rawashdeh, Yazan F.</creatorcontrib><creatorcontrib>Christensen, Peter</creatorcontrib><creatorcontrib>Krogh, Klaus</creatorcontrib><creatorcontrib>Fuglsang-Frederiksen, Anders</creatorcontrib><title>Peripheral nervous system involvement in chronic spinal cord injury</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>ABSTRACT
Introduction: Upper motor neuron disorders are believed to leave the peripheral nervous system (PNS) intact. In this study we examined whether there is evidence of PNS involvement in spinal cord injury (SCI). Methods: Twelve subjects with chronic low cervical or thoracic SCI were included prospectively. Needle electromyography was done in 10 different muscles in each subject bilaterally. Nerve conduction studies (NCS) were conducted in the fibular, tibial, and femoral motor and fibular and sural sensory nerves. Results: Half the subjects had widespread abnormal spontaneous activity (SA), and the amount of SA correlated inversely with reflex activity and nerve length. Fibular nerve entrapment across the knee was seen in 6 subjects, and sciatic nerve entrapment was seen in 1. Apart from entrapment neuropathies, NCS changes were found predominantly in motor nerves. Conclusion: The presence of widespread electrophysiologic changes outside entrapment sites indicates that SCI has a significant impact on the entire PNS, affecting the motor part predominantly. Muscle Nerve 52: 1016–1022, 2015</description><subject>Adult</subject><subject>Chronic Disease</subject><subject>Electromyography</subject><subject>Evoked Potentials, Somatosensory - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nerve conduction study</subject><subject>Neural Conduction - physiology</subject><subject>peripheral nervous system</subject><subject>Peripheral Nervous System Diseases - diagnosis</subject><subject>Peripheral Nervous System Diseases - etiology</subject><subject>Reaction Time - physiology</subject><subject>Spinal Cord Injuries - complications</subject><subject>spinal cord injury</subject><subject>spontaneous activity</subject><subject>Statistics, Nonparametric</subject><subject>Young Adult</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtKAzEUhoMotl4WvoDMUhejSSbXpRSrgje8oLgJmfQMnTqXmnSqfXuj1e4EV-dw-P6fw4fQHsFHBGN6XHfhiDLB2BrqE6xlyrhW66iPCVOpyPRzD22FMMEYEyXkJupRLrniHPfR4BZ8OR2Dt1XSgJ-3XUjCIsygTspm3lZzqKGZxT1xY982pUvCtGwi7Fo_iudJ5xc7aKOwVYDdn7mNHoenD4Pz9PLm7GJwcpk6JgRLCR3loKyTdkRzV9iCOuoUBa5czpkAAgVmGaMFE1oDcE6Us1JILSm3lufZNjpY9k59-9ZBmJm6DA6qyjYQ_zZEKswxI4r9AxVYaS2YjujhEnW-DcFDYaa-rK1fGILNl14T9ZpvvZHd_6nt8hpGK_LXZwSOl8B7WcHi7yZz9Xj_W5kuE2WU_rFKWP9qhMwkN0_XZ-b8dvgyvGIDc5d9AmMWlDs</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Tankisi, Hatice</creator><creator>Pugdahl, Kirsten</creator><creator>Rasmussen, Mikkel Mylius</creator><creator>Clemmensen, Dorte</creator><creator>Rawashdeh, Yazan F.</creator><creator>Christensen, Peter</creator><creator>Krogh, Klaus</creator><creator>Fuglsang-Frederiksen, Anders</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201512</creationdate><title>Peripheral nervous system involvement in chronic spinal cord injury</title><author>Tankisi, Hatice ; Pugdahl, Kirsten ; Rasmussen, Mikkel Mylius ; Clemmensen, Dorte ; Rawashdeh, Yazan F. ; Christensen, Peter ; Krogh, Klaus ; Fuglsang-Frederiksen, Anders</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4664-12dbe8ac7ad2bcfaf2c2c82e58cb546e1ef04342f4699ee5518ca7679725aa5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Chronic Disease</topic><topic>Electromyography</topic><topic>Evoked Potentials, Somatosensory - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nerve conduction study</topic><topic>Neural Conduction - physiology</topic><topic>peripheral nervous system</topic><topic>Peripheral Nervous System Diseases - diagnosis</topic><topic>Peripheral Nervous System Diseases - etiology</topic><topic>Reaction Time - physiology</topic><topic>Spinal Cord Injuries - complications</topic><topic>spinal cord injury</topic><topic>spontaneous activity</topic><topic>Statistics, Nonparametric</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tankisi, Hatice</creatorcontrib><creatorcontrib>Pugdahl, Kirsten</creatorcontrib><creatorcontrib>Rasmussen, Mikkel Mylius</creatorcontrib><creatorcontrib>Clemmensen, Dorte</creatorcontrib><creatorcontrib>Rawashdeh, Yazan F.</creatorcontrib><creatorcontrib>Christensen, Peter</creatorcontrib><creatorcontrib>Krogh, Klaus</creatorcontrib><creatorcontrib>Fuglsang-Frederiksen, Anders</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tankisi, Hatice</au><au>Pugdahl, Kirsten</au><au>Rasmussen, Mikkel Mylius</au><au>Clemmensen, Dorte</au><au>Rawashdeh, Yazan F.</au><au>Christensen, Peter</au><au>Krogh, Klaus</au><au>Fuglsang-Frederiksen, Anders</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral nervous system involvement in chronic spinal cord injury</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2015-12</date><risdate>2015</risdate><volume>52</volume><issue>6</issue><spage>1016</spage><epage>1022</epage><pages>1016-1022</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>ABSTRACT
Introduction: Upper motor neuron disorders are believed to leave the peripheral nervous system (PNS) intact. In this study we examined whether there is evidence of PNS involvement in spinal cord injury (SCI). Methods: Twelve subjects with chronic low cervical or thoracic SCI were included prospectively. Needle electromyography was done in 10 different muscles in each subject bilaterally. Nerve conduction studies (NCS) were conducted in the fibular, tibial, and femoral motor and fibular and sural sensory nerves. Results: Half the subjects had widespread abnormal spontaneous activity (SA), and the amount of SA correlated inversely with reflex activity and nerve length. Fibular nerve entrapment across the knee was seen in 6 subjects, and sciatic nerve entrapment was seen in 1. Apart from entrapment neuropathies, NCS changes were found predominantly in motor nerves. Conclusion: The presence of widespread electrophysiologic changes outside entrapment sites indicates that SCI has a significant impact on the entire PNS, affecting the motor part predominantly. Muscle Nerve 52: 1016–1022, 2015</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25758550</pmid><doi>10.1002/mus.24644</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Chronic Disease Electromyography Evoked Potentials, Somatosensory - physiology Female Humans Male Middle Aged nerve conduction study Neural Conduction - physiology peripheral nervous system Peripheral Nervous System Diseases - diagnosis Peripheral Nervous System Diseases - etiology Reaction Time - physiology Spinal Cord Injuries - complications spinal cord injury spontaneous activity Statistics, Nonparametric Young Adult |
| title | Peripheral nervous system involvement in chronic spinal cord injury |
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