Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling

Summary Icaritin, a hydrolytic product of icariin from the Epimedium genus, exerts anti‐tumour effects on a variety of tumour cell types, mainly by inhibiting cell proliferation and inducing apoptosis. However, little is known about the role of icaritin in cancer invasion and epithelial‐to‐mesenchym...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2015-12, Vol.42 (12), p.1296-1307
Hauptverfasser:	Xu, Bo, Jiang, Chuanwu, Han, Hongxing, Liu, Hong, Tang, Ming, Liu, Longxi, Ji, Wenyan, Lu, Xuechao, Yang, Xiuli, Zhang, Yunxu, Liu, Yongji
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Antineoplastic Agents - pharmacology Apoptosis - drug effects Basigin - genetics Basigin - metabolism Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Epimedium Epithelial-Mesenchymal Transition - drug effects extracellular matrix metalloproteinase Flavonoids - pharmacology Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques glioblastoma Glioblastoma - pathology HIF-1α Humans Hypoxia-Inducible Factor 1, alpha Subunit - deficiency Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism icaritin Molecular Targeted Therapy Neoplasm Invasiveness Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism Signal Transduction - drug effects
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