(R)-α-Lipoyl-Glycyl-L-Prolyl-L-Glutamyl Dimethyl Ester Codrug as a Multifunctional Agent with Potential Neuroprotective Activities

The (R)‐α‐lipoyl‐glycyl‐L‐prolyl‐L‐glutamyl dimethyl ester codrug (LA‐GPE, 1) was synthesized as a new multifunctional drug candidate with antioxidant and neuroprotective properties for the treatment of neurodegenerative diseases. Physicochemical properties, chemical and enzymatic stabilities were e...

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Veröffentlicht in:	ChemMedChem 2012-11, Vol.7 (11), p.2021-2029
Hauptverfasser:	Cacciatore, Ivana, Baldassarre, Leonardo, Fornasari, Erika, Cornacchia, Catia, Di Stefano, Antonio, Sozio, Piera, Cerasa, Laura Serafina, Fontana, Antonella, Fulle, Stefania, Di Filippo, Ester Sara, La Rovere, Rita Maria Laura, Pinnen, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	(R)-α-lipoic acid antioxidants Antioxidants - chemistry Antioxidants - pharmacokinetics Antioxidants - pharmacology Blood-Brain Barrier - metabolism Cell Line, Tumor glycyl-L-prolyl-L-glutamate Humans Hydrogen Peroxide - metabolism Neuroblastoma - drug therapy Neuroblastoma - metabolism neurodegenerative diseases neurological agents Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacokinetics Neuroprotective Agents - pharmacology Oligopeptides - chemistry Oligopeptides - pharmacokinetics Oligopeptides - pharmacology Oxidative Stress - drug effects peptides Thioctic Acid - analogs & derivatives Thioctic Acid - pharmacokinetics Thioctic Acid - pharmacology
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