New bone formation induced by surface strontium-modified ceramic bone graft substitute
Objectives This study assessed the effect of surface strontium ion (Sr) modification on the osteogenic activity of an osteoconductive ceramic bone graft substitute with the hope of using the bone healing effect of Sr for potential application in periodontal and maxillofacial regenerative surgery. Ma...
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| Veröffentlicht in: | Oral diseases 2016-01, Vol.22 (1), p.53-61 |
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| creator | Park, J-W Kang, D-G Hanawa, T |
| description | Objectives
This study assessed the effect of surface strontium ion (Sr) modification on the osteogenic activity of an osteoconductive ceramic bone graft substitute with the hope of using the bone healing effect of Sr for potential application in periodontal and maxillofacial regenerative surgery.
Materials and Methods
A simple wet chemical treatment was employed to deliver Sr to the surface of particulate porcine bone graft. The osteogenic activity of surface Sr‐modified bone substitute was compared in vitro and in vivo with that of unmodified ceramic bone, other clinically available synthetic bone or osteoinductive allograft bone.
Results
The resultant bone substitute showed the formation of Sr‐containing microstructured surface layer along with the formation of additional nanostructures and displayed sustained Sr release. Sr modification promoted the osteogenic differentiation of bipotential ST2 stem cells. Sr‐modified bone substitute increased the amount of newly formed bone at early healing period in calvarial defect of rabbits.
Conclusions
These results suggest that the surface Sr modification by wet chemical treatment is a promising approach to enhance the early bone healing capacity of osteoconductive ceramic bone substitutes. |
| doi_str_mv | 10.1111/odi.12381 |
| format | Article |
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This study assessed the effect of surface strontium ion (Sr) modification on the osteogenic activity of an osteoconductive ceramic bone graft substitute with the hope of using the bone healing effect of Sr for potential application in periodontal and maxillofacial regenerative surgery.
Materials and Methods
A simple wet chemical treatment was employed to deliver Sr to the surface of particulate porcine bone graft. The osteogenic activity of surface Sr‐modified bone substitute was compared in vitro and in vivo with that of unmodified ceramic bone, other clinically available synthetic bone or osteoinductive allograft bone.
Results
The resultant bone substitute showed the formation of Sr‐containing microstructured surface layer along with the formation of additional nanostructures and displayed sustained Sr release. Sr modification promoted the osteogenic differentiation of bipotential ST2 stem cells. Sr‐modified bone substitute increased the amount of newly formed bone at early healing period in calvarial defect of rabbits.
Conclusions
These results suggest that the surface Sr modification by wet chemical treatment is a promising approach to enhance the early bone healing capacity of osteoconductive ceramic bone substitutes.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.12381</identifier><identifier>PMID: 26458092</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Animals ; Bone Development - drug effects ; bone graft substitute ; bone regeneration ; Bone Regeneration - drug effects ; Bone Substitutes - chemistry ; Bone Substitutes - pharmacology ; Bones ; Cell Differentiation ; Ceramics ; Ceramics - chemistry ; Ceramics - pharmacology ; Dental surgery ; histomorphometry ; Maxilla - surgery ; Maxilla - transplantation ; Maxillofacial surgery ; Models, Animal ; osteoblast differentiation ; Osteoblasts - cytology ; Osteoblasts - drug effects ; Osteogenesis - drug effects ; Osteogenesis - genetics ; Rabbits ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Stromal Cells ; Strontium - chemistry ; Strontium - pharmacology ; Surface Properties ; Swine ; Transcription Factors</subject><ispartof>Oral diseases, 2016-01, Vol.22 (1), p.53-61</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4941-28619a4d13279e0c07643a490a09d15e86081eb367a2e0b73e4095e6a64792353</citedby><cites>FETCH-LOGICAL-c4941-28619a4d13279e0c07643a490a09d15e86081eb367a2e0b73e4095e6a64792353</cites><orcidid>0000-0002-6632-023X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.12381$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.12381$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26458092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, J-W</creatorcontrib><creatorcontrib>Kang, D-G</creatorcontrib><creatorcontrib>Hanawa, T</creatorcontrib><title>New bone formation induced by surface strontium-modified ceramic bone graft substitute</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objectives
This study assessed the effect of surface strontium ion (Sr) modification on the osteogenic activity of an osteoconductive ceramic bone graft substitute with the hope of using the bone healing effect of Sr for potential application in periodontal and maxillofacial regenerative surgery.
Materials and Methods
A simple wet chemical treatment was employed to deliver Sr to the surface of particulate porcine bone graft. The osteogenic activity of surface Sr‐modified bone substitute was compared in vitro and in vivo with that of unmodified ceramic bone, other clinically available synthetic bone or osteoinductive allograft bone.
Results
The resultant bone substitute showed the formation of Sr‐containing microstructured surface layer along with the formation of additional nanostructures and displayed sustained Sr release. Sr modification promoted the osteogenic differentiation of bipotential ST2 stem cells. Sr‐modified bone substitute increased the amount of newly formed bone at early healing period in calvarial defect of rabbits.
Conclusions
These results suggest that the surface Sr modification by wet chemical treatment is a promising approach to enhance the early bone healing capacity of osteoconductive ceramic bone substitutes.</description><subject>Animals</subject><subject>Bone Development - drug effects</subject><subject>bone graft substitute</subject><subject>bone regeneration</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone Substitutes - chemistry</subject><subject>Bone Substitutes - pharmacology</subject><subject>Bones</subject><subject>Cell Differentiation</subject><subject>Ceramics</subject><subject>Ceramics - chemistry</subject><subject>Ceramics - pharmacology</subject><subject>Dental surgery</subject><subject>histomorphometry</subject><subject>Maxilla - surgery</subject><subject>Maxilla - transplantation</subject><subject>Maxillofacial surgery</subject><subject>Models, Animal</subject><subject>osteoblast differentiation</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - drug effects</subject><subject>Osteogenesis - drug effects</subject><subject>Osteogenesis - genetics</subject><subject>Rabbits</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Stromal Cells</subject><subject>Strontium - chemistry</subject><subject>Strontium - pharmacology</subject><subject>Surface Properties</subject><subject>Swine</subject><subject>Transcription Factors</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtO3DAYhS1UBJSy6AtUkbppFxl8d7ysKFeNBqnipm4sJ_lTmU7iwXZE5-1rCMwCCW9syd_5fvsg9JngGcnr0LduRiiryBbaIxKTEldUfMhnJngpKLvbRR9jvMeYKM3oDtqlkosKa7qHbhbwWNR-gKLzobfJ-aFwQzs20Bb1uohj6GwDRUzBD8mNfdnnYZ3Ltw0E27tmCv8JtkuZrmNyaUzwCW13dhnh4GXfR9cnx1dHZ-X88vT86Me8bLjmpKSVJNryljCqNOAGK8mZ5RpbrFsioJK4IlAzqSwFXCsGHGsB0kquNGWC7aNvk3cV_MMIMZnexQaWSzuAH6MhqsICZwnN6Nc36L0fw5BflymhRMWIfKK-T1QTfIwBOrMKrrdhbQg2T2Wb_H_zXHZmv7wYx7qHdkO-tpuBwwl4dEtYv28ylz_PX5XllHAxwb9Nwoa_RiqmhLldnJqrxe3FLzqn5jf7D267liI</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Park, J-W</creator><creator>Kang, D-G</creator><creator>Hanawa, T</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-6632-023X</orcidid></search><sort><creationdate>201601</creationdate><title>New bone formation induced by surface strontium-modified ceramic bone graft substitute</title><author>Park, J-W ; Kang, D-G ; Hanawa, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4941-28619a4d13279e0c07643a490a09d15e86081eb367a2e0b73e4095e6a64792353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bone Development - drug effects</topic><topic>bone graft substitute</topic><topic>bone regeneration</topic><topic>Bone Regeneration - drug effects</topic><topic>Bone Substitutes - chemistry</topic><topic>Bone Substitutes - pharmacology</topic><topic>Bones</topic><topic>Cell Differentiation</topic><topic>Ceramics</topic><topic>Ceramics - chemistry</topic><topic>Ceramics - pharmacology</topic><topic>Dental surgery</topic><topic>histomorphometry</topic><topic>Maxilla - surgery</topic><topic>Maxilla - transplantation</topic><topic>Maxillofacial surgery</topic><topic>Models, Animal</topic><topic>osteoblast differentiation</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - drug effects</topic><topic>Osteogenesis - drug effects</topic><topic>Osteogenesis - genetics</topic><topic>Rabbits</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Stromal Cells</topic><topic>Strontium - chemistry</topic><topic>Strontium - pharmacology</topic><topic>Surface Properties</topic><topic>Swine</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, J-W</creatorcontrib><creatorcontrib>Kang, D-G</creatorcontrib><creatorcontrib>Hanawa, T</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, J-W</au><au>Kang, D-G</au><au>Hanawa, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New bone formation induced by surface strontium-modified ceramic bone graft substitute</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2016-01</date><risdate>2016</risdate><volume>22</volume><issue>1</issue><spage>53</spage><epage>61</epage><pages>53-61</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objectives
This study assessed the effect of surface strontium ion (Sr) modification on the osteogenic activity of an osteoconductive ceramic bone graft substitute with the hope of using the bone healing effect of Sr for potential application in periodontal and maxillofacial regenerative surgery.
Materials and Methods
A simple wet chemical treatment was employed to deliver Sr to the surface of particulate porcine bone graft. The osteogenic activity of surface Sr‐modified bone substitute was compared in vitro and in vivo with that of unmodified ceramic bone, other clinically available synthetic bone or osteoinductive allograft bone.
Results
The resultant bone substitute showed the formation of Sr‐containing microstructured surface layer along with the formation of additional nanostructures and displayed sustained Sr release. Sr modification promoted the osteogenic differentiation of bipotential ST2 stem cells. Sr‐modified bone substitute increased the amount of newly formed bone at early healing period in calvarial defect of rabbits.
Conclusions
These results suggest that the surface Sr modification by wet chemical treatment is a promising approach to enhance the early bone healing capacity of osteoconductive ceramic bone substitutes.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>26458092</pmid><doi>10.1111/odi.12381</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6632-023X</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Bone Development - drug effects bone graft substitute bone regeneration Bone Regeneration - drug effects Bone Substitutes - chemistry Bone Substitutes - pharmacology Bones Cell Differentiation Ceramics Ceramics - chemistry Ceramics - pharmacology Dental surgery histomorphometry Maxilla - surgery Maxilla - transplantation Maxillofacial surgery Models, Animal osteoblast differentiation Osteoblasts - cytology Osteoblasts - drug effects Osteogenesis - drug effects Osteogenesis - genetics Rabbits RNA, Messenger - biosynthesis RNA, Messenger - genetics Stromal Cells Strontium - chemistry Strontium - pharmacology Surface Properties Swine Transcription Factors |
| title | New bone formation induced by surface strontium-modified ceramic bone graft substitute |
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