Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of hiv-infected drug users
To identify subsets of CD4 T lymphocytes that can predict the development of AIDS and to assess whether increased levels of these cellular markers could provide additional independent prognostic information to the CD4 T cell count and plasma HIV-1-RNA levels. In a prospective study, a cohort of 85 H...
Gespeichert in:
Veröffentlicht in: | AIDS (London) 2000-12, Vol.14 (18), p.2823-2829 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 2829 |
---|---|
container_issue | 18 |
container_start_page | 2823 |
container_title | AIDS (London) |
container_volume | 14 |
creator | CARBONE, Javier GIL, Juana BENITO, José M NAVARRO, Joaquin MUNOZ-FERNANDEZ, Angeles BARTOLOME, Joaquin ZABAY, José M LOPEZ, Francisco FERNANDEZ-CRUZ, Eduardo |
description | To identify subsets of CD4 T lymphocytes that can predict the development of AIDS and to assess whether increased levels of these cellular markers could provide additional independent prognostic information to the CD4 T cell count and plasma HIV-1-RNA levels.
In a prospective study, a cohort of 85 HIV-positive intravenous drug users [clinical categories of the CDC classification A (n = 48) and B (n = 37)] were followed for a period of 37+/-13 months. Memory and activated CD4 and CD8 T cells were quantitated by three-colour flow cytometry at baseline and expressed as a percentage of total CD4 and CD8 lymphocytes. Clinical evaluations were performed at 6 month intervals. The relationships between these lymphocyte subsets and progression to AIDS were studied using Kaplan-Meier plots and proportional hazards regression models.
After adjustment for the level of CD4 T cells and plasma HIV-1-RNA levels, the elevation in the subset CD4+CD38+DR+ was the marker within the functionally distinct subsets of CD4 T lymphocytes with additional prognostic value in bivariate Cox regression models. In multivariate models, increased percentages of CD4+CD38+DR+ T cells provided the strongest independent prognostic information for progression to AIDS (relative hazard, 1.07; P < 0.0001).
Our results suggest that high levels of CD4+CD38+HLA-DR+ T cells reflect the increasing degree of CD4 T cell activation during the progression of HIV infection, and could be used together with the CD4 T cell and HIV-RNA levels to evaluate more accurately the progressive cellular immune impairment associated with the risk of progression to AIDS. |
doi_str_mv | 10.1097/00002030-200012220-00003 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17802635</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17802635</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-a04842537be8ca417355219184bb15825f8b8d3ae8c4a8d81e2c465c09237b8c3</originalsourceid><addsrcrecordid>eNpNkclOwzAQhi0EgrK8ArKExC3gtXGOqKwSEpdyjhxnQoPSuHicIt6CR8aBUvDFo9_fLJ6fEMrZBWdFfsnSEUyyTKSACyFYNkpyh0y4ymWmdc53yYSJaZEVMmcH5BDxNRGaGbNPDjjnWk6nckI-H3oXwCLUtIM1dEh9Q62L7drGpOFQIcRvcXat6Jw66BJj65pGT-MC6Cr4l95jbB1d226AEe38-z-cOj_0qUbbU5vihQ9xhBbtOmv7BtzYpw7DCx0QAh6TvcZ2CCeb-4g8397MZ_fZ49Pdw-zqMXNKsJhZpowSWuYVGGcVz6XWghfcqKri2gjdmMrU0qZXZU1tOAinptqxQqQc4-QROf-pmz7wNgDGctniOK7twQ9Y8tyk9UmdQPMDuuARAzTlKrRLGz5KzsrRjfLXjXLrxrckU-rppsdQLaH-S9ysPwFnG8Cis10TbO9a3HLGSKGY_AJYiJCj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17802635</pqid></control><display><type>article</type><title>Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of hiv-infected drug users</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>CARBONE, Javier ; GIL, Juana ; BENITO, José M ; NAVARRO, Joaquin ; MUNOZ-FERNANDEZ, Angeles ; BARTOLOME, Joaquin ; ZABAY, José M ; LOPEZ, Francisco ; FERNANDEZ-CRUZ, Eduardo</creator><creatorcontrib>CARBONE, Javier ; GIL, Juana ; BENITO, José M ; NAVARRO, Joaquin ; MUNOZ-FERNANDEZ, Angeles ; BARTOLOME, Joaquin ; ZABAY, José M ; LOPEZ, Francisco ; FERNANDEZ-CRUZ, Eduardo</creatorcontrib><description>To identify subsets of CD4 T lymphocytes that can predict the development of AIDS and to assess whether increased levels of these cellular markers could provide additional independent prognostic information to the CD4 T cell count and plasma HIV-1-RNA levels.
In a prospective study, a cohort of 85 HIV-positive intravenous drug users [clinical categories of the CDC classification A (n = 48) and B (n = 37)] were followed for a period of 37+/-13 months. Memory and activated CD4 and CD8 T cells were quantitated by three-colour flow cytometry at baseline and expressed as a percentage of total CD4 and CD8 lymphocytes. Clinical evaluations were performed at 6 month intervals. The relationships between these lymphocyte subsets and progression to AIDS were studied using Kaplan-Meier plots and proportional hazards regression models.
After adjustment for the level of CD4 T cells and plasma HIV-1-RNA levels, the elevation in the subset CD4+CD38+DR+ was the marker within the functionally distinct subsets of CD4 T lymphocytes with additional prognostic value in bivariate Cox regression models. In multivariate models, increased percentages of CD4+CD38+DR+ T cells provided the strongest independent prognostic information for progression to AIDS (relative hazard, 1.07; P < 0.0001).
Our results suggest that high levels of CD4+CD38+HLA-DR+ T cells reflect the increasing degree of CD4 T cell activation during the progression of HIV infection, and could be used together with the CD4 T cell and HIV-RNA levels to evaluate more accurately the progressive cellular immune impairment associated with the risk of progression to AIDS.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-200012220-00003</identifier><identifier>PMID: 11153663</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; CD4 antigen ; CD4 Lymphocyte Count ; Cohort Studies ; Female ; HIV Infections - diagnosis ; HIV Infections - immunology ; HIV Infections - physiopathology ; HIV-1 - physiology ; human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Lymphocyte Activation - immunology ; Male ; Medical sciences ; Prognosis ; Prospective Studies ; RNA, Viral - blood ; Substance Abuse, Intravenous - complications ; Substance Abuse, Intravenous - immunology ; T-Lymphocyte Subsets - immunology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2000-12, Vol.14 (18), p.2823-2829</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-a04842537be8ca417355219184bb15825f8b8d3ae8c4a8d81e2c465c09237b8c3</citedby><cites>FETCH-LOGICAL-c420t-a04842537be8ca417355219184bb15825f8b8d3ae8c4a8d81e2c465c09237b8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=883240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11153663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CARBONE, Javier</creatorcontrib><creatorcontrib>GIL, Juana</creatorcontrib><creatorcontrib>BENITO, José M</creatorcontrib><creatorcontrib>NAVARRO, Joaquin</creatorcontrib><creatorcontrib>MUNOZ-FERNANDEZ, Angeles</creatorcontrib><creatorcontrib>BARTOLOME, Joaquin</creatorcontrib><creatorcontrib>ZABAY, José M</creatorcontrib><creatorcontrib>LOPEZ, Francisco</creatorcontrib><creatorcontrib>FERNANDEZ-CRUZ, Eduardo</creatorcontrib><title>Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of hiv-infected drug users</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To identify subsets of CD4 T lymphocytes that can predict the development of AIDS and to assess whether increased levels of these cellular markers could provide additional independent prognostic information to the CD4 T cell count and plasma HIV-1-RNA levels.
In a prospective study, a cohort of 85 HIV-positive intravenous drug users [clinical categories of the CDC classification A (n = 48) and B (n = 37)] were followed for a period of 37+/-13 months. Memory and activated CD4 and CD8 T cells were quantitated by three-colour flow cytometry at baseline and expressed as a percentage of total CD4 and CD8 lymphocytes. Clinical evaluations were performed at 6 month intervals. The relationships between these lymphocyte subsets and progression to AIDS were studied using Kaplan-Meier plots and proportional hazards regression models.
After adjustment for the level of CD4 T cells and plasma HIV-1-RNA levels, the elevation in the subset CD4+CD38+DR+ was the marker within the functionally distinct subsets of CD4 T lymphocytes with additional prognostic value in bivariate Cox regression models. In multivariate models, increased percentages of CD4+CD38+DR+ T cells provided the strongest independent prognostic information for progression to AIDS (relative hazard, 1.07; P < 0.0001).
Our results suggest that high levels of CD4+CD38+HLA-DR+ T cells reflect the increasing degree of CD4 T cell activation during the progression of HIV infection, and could be used together with the CD4 T cell and HIV-RNA levels to evaluate more accurately the progressive cellular immune impairment associated with the risk of progression to AIDS.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - physiopathology</subject><subject>HIV-1 - physiology</subject><subject>human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lymphocyte Activation - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>RNA, Viral - blood</subject><subject>Substance Abuse, Intravenous - complications</subject><subject>Substance Abuse, Intravenous - immunology</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkclOwzAQhi0EgrK8ArKExC3gtXGOqKwSEpdyjhxnQoPSuHicIt6CR8aBUvDFo9_fLJ6fEMrZBWdFfsnSEUyyTKSACyFYNkpyh0y4ymWmdc53yYSJaZEVMmcH5BDxNRGaGbNPDjjnWk6nckI-H3oXwCLUtIM1dEh9Q62L7drGpOFQIcRvcXat6Jw66BJj65pGT-MC6Cr4l95jbB1d226AEe38-z-cOj_0qUbbU5vihQ9xhBbtOmv7BtzYpw7DCx0QAh6TvcZ2CCeb-4g8397MZ_fZ49Pdw-zqMXNKsJhZpowSWuYVGGcVz6XWghfcqKri2gjdmMrU0qZXZU1tOAinptqxQqQc4-QROf-pmz7wNgDGctniOK7twQ9Y8tyk9UmdQPMDuuARAzTlKrRLGz5KzsrRjfLXjXLrxrckU-rppsdQLaH-S9ysPwFnG8Cis10TbO9a3HLGSKGY_AJYiJCj</recordid><startdate>20001222</startdate><enddate>20001222</enddate><creator>CARBONE, Javier</creator><creator>GIL, Juana</creator><creator>BENITO, José M</creator><creator>NAVARRO, Joaquin</creator><creator>MUNOZ-FERNANDEZ, Angeles</creator><creator>BARTOLOME, Joaquin</creator><creator>ZABAY, José M</creator><creator>LOPEZ, Francisco</creator><creator>FERNANDEZ-CRUZ, Eduardo</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20001222</creationdate><title>Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of hiv-infected drug users</title><author>CARBONE, Javier ; GIL, Juana ; BENITO, José M ; NAVARRO, Joaquin ; MUNOZ-FERNANDEZ, Angeles ; BARTOLOME, Joaquin ; ZABAY, José M ; LOPEZ, Francisco ; FERNANDEZ-CRUZ, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-a04842537be8ca417355219184bb15825f8b8d3ae8c4a8d81e2c465c09237b8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>CD4 antigen</topic><topic>CD4 Lymphocyte Count</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - physiopathology</topic><topic>HIV-1 - physiology</topic><topic>human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lymphocyte Activation - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>RNA, Viral - blood</topic><topic>Substance Abuse, Intravenous - complications</topic><topic>Substance Abuse, Intravenous - immunology</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CARBONE, Javier</creatorcontrib><creatorcontrib>GIL, Juana</creatorcontrib><creatorcontrib>BENITO, José M</creatorcontrib><creatorcontrib>NAVARRO, Joaquin</creatorcontrib><creatorcontrib>MUNOZ-FERNANDEZ, Angeles</creatorcontrib><creatorcontrib>BARTOLOME, Joaquin</creatorcontrib><creatorcontrib>ZABAY, José M</creatorcontrib><creatorcontrib>LOPEZ, Francisco</creatorcontrib><creatorcontrib>FERNANDEZ-CRUZ, Eduardo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CARBONE, Javier</au><au>GIL, Juana</au><au>BENITO, José M</au><au>NAVARRO, Joaquin</au><au>MUNOZ-FERNANDEZ, Angeles</au><au>BARTOLOME, Joaquin</au><au>ZABAY, José M</au><au>LOPEZ, Francisco</au><au>FERNANDEZ-CRUZ, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of hiv-infected drug users</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2000-12-22</date><risdate>2000</risdate><volume>14</volume><issue>18</issue><spage>2823</spage><epage>2829</epage><pages>2823-2829</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>To identify subsets of CD4 T lymphocytes that can predict the development of AIDS and to assess whether increased levels of these cellular markers could provide additional independent prognostic information to the CD4 T cell count and plasma HIV-1-RNA levels.
In a prospective study, a cohort of 85 HIV-positive intravenous drug users [clinical categories of the CDC classification A (n = 48) and B (n = 37)] were followed for a period of 37+/-13 months. Memory and activated CD4 and CD8 T cells were quantitated by three-colour flow cytometry at baseline and expressed as a percentage of total CD4 and CD8 lymphocytes. Clinical evaluations were performed at 6 month intervals. The relationships between these lymphocyte subsets and progression to AIDS were studied using Kaplan-Meier plots and proportional hazards regression models.
After adjustment for the level of CD4 T cells and plasma HIV-1-RNA levels, the elevation in the subset CD4+CD38+DR+ was the marker within the functionally distinct subsets of CD4 T lymphocytes with additional prognostic value in bivariate Cox regression models. In multivariate models, increased percentages of CD4+CD38+DR+ T cells provided the strongest independent prognostic information for progression to AIDS (relative hazard, 1.07; P < 0.0001).
Our results suggest that high levels of CD4+CD38+HLA-DR+ T cells reflect the increasing degree of CD4 T cell activation during the progression of HIV infection, and could be used together with the CD4 T cell and HIV-RNA levels to evaluate more accurately the progressive cellular immune impairment associated with the risk of progression to AIDS.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11153663</pmid><doi>10.1097/00002030-200012220-00003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0269-9370 |
ispartof | AIDS (London), 2000-12, Vol.14 (18), p.2823-2829 |
issn | 0269-9370 1473-5571 |
language | eng |
recordid | cdi_proquest_miscellaneous_17802635 |
source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
subjects | Adult Biological and medical sciences CD4 antigen CD4 Lymphocyte Count Cohort Studies Female HIV Infections - diagnosis HIV Infections - immunology HIV Infections - physiopathology HIV-1 - physiology human immunodeficiency virus Human viral diseases Humans Infectious diseases Lymphocyte Activation - immunology Male Medical sciences Prognosis Prospective Studies RNA, Viral - blood Substance Abuse, Intravenous - complications Substance Abuse, Intravenous - immunology T-Lymphocyte Subsets - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
title | Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of hiv-infected drug users |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T22%3A02%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20levels%20of%20activated%20subsets%20of%20CD4%20T%20cells%20add%20to%20the%20prognostic%20value%20of%20low%20CD4%20T%20cell%20counts%20in%20a%20cohort%20of%20hiv-infected%20drug%20users&rft.jtitle=AIDS%20(London)&rft.au=CARBONE,%20Javier&rft.date=2000-12-22&rft.volume=14&rft.issue=18&rft.spage=2823&rft.epage=2829&rft.pages=2823-2829&rft.issn=0269-9370&rft.eissn=1473-5571&rft_id=info:doi/10.1097/00002030-200012220-00003&rft_dat=%3Cproquest_cross%3E17802635%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17802635&rft_id=info:pmid/11153663&rfr_iscdi=true |